The Early Coagulopathy for the Prognosis in Sepsis

Status Not yet recruiting

Clinical Trial Summary

In this cohort study, the parameters (TM, TAT, PIC, tPAIC, et al.) associated with the hemostatic system will be collected in sepsis patients when admitted to the Intensive Critical Unit. Parameters will be evaluated for their prognostic function of 28 days mortality.

Clinical Trial Description

The object of this study is to find the early mortality prognostic biomarkers within the hemostatic system in sepsis patients. Blood samples will be collected from sepsis patients at admission. Parameters reflect endothelial injury, such as thrombomodulin (TM), tissue type plasminogen activator inhibitor complex (tPAIC), parameters reflect procoagulation condition, such as thrombin-antithrombin complex (TAT), and parameters reflect hyperfibrinolysis, such as plasmin-plasmin inhibitor complex (PIC) will be tested. Based on the results of these parameters, sepsis patients will be divided into coagulation parameter normal or abnormal groups. Twenty-eight days of mortality will be determined by patient follow-up. Regression analysis will be used to evaluate the relationship between these parameters and the mortality of sepsis patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04582188
Study type	Observational [Patient Registry]
Source	Wuhan Union Hospital, China
Contact	Huaqing Shu, Dr.
Phone	?13437284416
Email	370247973@qq.com
Status	Not yet recruiting
Phase
Start date	November 5, 2020
Completion date	December 31, 2022

View Details

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