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Hemostatic Disorders clinical trials

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NCT ID: NCT04960163 Not yet recruiting - Clinical trials for Acute-On-Chronic Liver Failure

Incidence and Predictors of Bleeding Diathesis Development Due to DIC in Cirrhosis and ACLF Patients Undergoing CRRT

Start date: July 15, 2021
Phase:
Study type: Observational

ACLF and cirrhotic patient have deranged coagulation parameters and this coagulation parameters altered when this group of patients undergoing dialysis because of renal failure. this group of patients is also high risk of sepsis. Most common organ involved during sepsis leading to organ failure is renal. So, all this cascade increases the risk of bleeding as well as coagulation failure. Currently there are no studies evaluation the coagulation status in patients with cirrhosis undergoing dialysis. Further there are no studies evaluating the utility of these global tests of coagulation as a guide to judicious blood transfusion in these patients to prevent bleeding. Further there are no studies comparing the two different modalities of assessment.

NCT ID: NCT04912336 Recruiting - Thrombosis Clinical Trials

Extracorporeal Life Support and Modification of Hemostasis

ELMOH
Start date: March 24, 2021
Phase:
Study type: Observational

To evaluate change in coagulation tests during a 48-h period after initiation VV-ECMO and VA-ECMO. (ECMO= Extra Corporeal Membrane Oxygenator) Assessment of bleeding during Veno-Venous Extracoporeal Membrane Oxygenator (VV-ECMO) and Veno-Arterial Extracoporeal Membrane Oxygenator (VA-ECMO).

NCT ID: NCT04896203 Recruiting - Clinical trials for Inflammatory Bowel Diseases

Hypercoagulability Study Using Haemostatic Techniques in Patients With Inflammatory Bowel Disease

EDGAR
Start date: November 18, 2020
Phase:
Study type: Observational

Descriptive study, in which the haemostatic profile of ambulatory patients with IBD will be analyzed by means of ROTEM and other techniques, such as the thrombin generation test and the study of platelet function by flow cytometry.

NCT ID: NCT04824118 Recruiting - Clinical trials for Venous Thromboembolism

Clotting Parameters After Medical Abortion

C-PLAN
Start date: March 26, 2021
Phase:
Study type: Observational

Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women. There is evidence that clotting parameters can take up to 6 weeks to return to normal for women who have had term deliveries, however there is an absence of information on time taken for clotting parameters to normalise following abortion. As such, existing guidelines are based solely on expert opinion and recommend durations of VTE prevention from as short as 7 days, up to 6 weeks following abortion. All women are assessed for risk of VTE, but data are needed to inform an evidence-based approach to prevention of VTE in these women. The findings from this pilot study have the potential to inform clinical guidance and possibly a larger study subsequently.

NCT ID: NCT04818970 Recruiting - Covid19 Clinical Trials

Photo-Protection Trial (NB-UVB vs. Placebo) in High-risk Hospitalized COVID-19 Patients

Start date: May 21, 2021
Phase: N/A
Study type: Interventional

The purpose of this study to evaluate the translational application of the safe and effective treatment of Narrow-Band Ultraviolet light B-band (NB-UVB) to high-risk COVID-19 patients in an effort to improve their immune and hemostatic imbalance to increase survival and improve outcomes.

NCT ID: NCT04777097 Recruiting - Blood Loss Clinical Trials

Blood Loss and Preeclampsia

Start date: January 1, 2021
Phase:
Study type: Observational

Study of blood loss in preeclamptic patients using mathematical formulae

NCT ID: NCT04762576 Not yet recruiting - Clinical trials for Coagulation Disorder

Thrombin in Cardiac Surgery

Start date: June 1, 2021
Phase:
Study type: Observational

Coagulopathy, bleeding, and transfusion are common in cardiac surgical patients. Our collaborator has developed a novel point of care device that can be used to assess thrombin generation in real-time in cardiac surgical patients. The investigators will measure thrombin generation using our novel device and compare it to standard methods, while examining the association of thrombin parameters with bleeding and other clinical outcomes.

NCT ID: NCT04762550 Recruiting - Clinical trials for Liver Transplantation

Thrombin Generation in Liver Transplant Surgery

Start date: March 8, 2021
Phase:
Study type: Observational

This is a prospective observational study of 100 patients undergoing liver transplantation at a single centre. Thrombin generation and kinetics will be assessed using a novel point-of-care device, and compared to conventional measures of hemostasis as well as viscoelastic tests to pinpoint specific coagulation deficits and identify potential therapeutic targets. The clinical course of patients will be followed for major bleeding and transfusion outcomes.

NCT ID: NCT04757285 Completed - Clinical trials for Psychological Stress

Copeptin and Psychological Stress of Medic During COVID-19 Pandemic

COVID-19
Start date: May 10, 2020
Phase:
Study type: Observational [Patient Registry]

Psychological stress (PSS) is one of the most common problems among healthcare providers during COVID-19 pandemic. PSS influences the homeostatic equilibrium of the body, involving activation of the sympathetic nervous system and hypothalamus pituitary adrenal (HPA) axis. Copeptin; C-terminal portion of Vasopressin (AVP) precursor is stable. Nevertheless, Evidence about influence of PSS on copeptin levels is lacking. The reason we are doing this research is to determine the level of psychological stress among healthcare providers exposed to at the time of work in intensive care unit (ICU) during COVID-19 pandemic; They will be appraised every assembly for psychological stress level; before start of duty shifts (first time), one week after start (second time) and two weeks after departure from shift duties in ICU (third time) for assessment of psychological stress level and stress hormones.

NCT ID: NCT04729946 Enrolling by invitation - Hemostatic Disorder Clinical Trials

Clinical and Urgent Colonoscopy Outcomes Using the Pure-Vu® Cleansing System

Start date: March 3, 2021
Phase: N/A
Study type: Interventional

The Pure-Vu® System can be effectively used as a cleansing device in patients admitted with acute LGIB to the intensive care unit and the regular nurse floor (RNF) bypassing the need to administer an oral bowel preparation for adequate visualization and hence decreasing time to colonoscopy and improving diagnostic and therapeutic yield.