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NCT06332768 Clinical Trial

NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients

Acute Respiratory Distress Syndrome Clinical Trial

Official title:
Comparison of High Flow Oxygenation, Noninvasive Ventilation and Standard Oxygen Therapy in the Early Post-extubation Period in Patients With Acute Respiratory Distress Syndrome

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06332768
Other study ID # WEAN_2021
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 1, 2017
Est. completion date March 1, 2022

Study information
Verified date March 2024
Source Northern State Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The weaning failure is a paramount challenge when aggressive discontinuation of respiratory support in ARDS. The aim of the study is to improve weaning safety and efficacy by a transient postextubation non-invasive respiratory support.

Description:

HFNO (high-flow nasal oxygenation and NIV (non invasive ventilation) are to be randomly compared in the ARDS postextubation period.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date March 1, 2022
Est. primary completion date January 1, 2022
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: ARDS Exclusion Criteria: Severe ICU-aquired weakness Severe COPD

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Respiratory support
High-flow nasal oxygenation

Locations
Country Name City State
Russian Federation City hospital # 1 Arkhangelsk Arkhangelsk Region

Sponsors (1)
Lead Sponsor Collaborator
Northern State Medical University

Country where clinical trial is conducted

Russian Federation, 

Outcome
Type Measure Description Time frame Safety issue
Primary Weaning failure Weaning failure and re-intubation or recanulation 48 hrs
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