Acute Respiratory Distress Syndrome Clinical Trial
Official title:
Comparative Study Between the Effect of Nebulized and Intravenous Hypertonic Saline 3% on the Management of Patients With Acute Respiratory Distress Syndrome
The aim of our study is to compare between the effect of nebulized and intravenous injection of hypertonic saline 3% on the outcome of patients with acute respiratory distress syndrome.
Status | Recruiting |
Enrollment | 105 |
Est. completion date | September 1, 2024 |
Est. primary completion date | September 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 21 Years to 60 Years |
Eligibility | Inclusion Criteria: - Age from 21 to 60 years old. - Both sexes. - Patients with mild and moderate ARDS whose PaO2/FiO2 ratio = 150 according to the Berlin definition of Acute Respiratory Distress Syndrome. Exclusion Criteria: - Refusal to participate in the study. - Malignancy. - Patients on chemotherapy. - Decompensated renal, hepatic and cardiac disease. - Patients with hypernatremia whose serum Na above 155 mEq/L. - Patients with ARDS whose PaO2/FiO2 ratio > 150. |
Country | Name | City | State |
---|---|---|---|
Egypt | Tanta University | Tanta | El-Gharbia |
Lead Sponsor | Collaborator |
---|---|
Tanta University |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of patients who will need mechanical ventilation | Number of patients who will need mechanical ventilation will be assessed. | 28 days after intervention | |
Secondary | Length of ICU stay | Length of ICU stay will be measured from the admission till the discharge from the hospital. | 28 days after intervention | |
Secondary | Lung injury score (Murray score) | Murray score (lung injury score) will be calculated daily in the morning based on information obtained from:
Number of quadrants of infiltrations from chest X-ray. Hypoxic index. Positive end expiratory pressure (PEEP) required on the ventilator to get better oxygenation. Static compliance. |
24 hours after intervention | |
Secondary | Incidence of mortality | Incidence of mortality will be assessed at 7th, and 28th day. | 28 days after intervention |
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