Ventilation Therapy; Complications Clinical Trial
Official title:
Study to Investigate an Association Between Brain Activity and Tidal Volume in Humans (BATMAN) - a Pilot Study
The communication between the lungs and the brain has drawn a lot of attention recently. Animal studies have shown that the breathing cycle is coupled with brain activity, showing that the greater the volume of air delivered to the lungs via a breathing machine greater the brain activity and also the greater the injury to the brain cells. There is no study in humans that investigates the physiological communication between the volume of air delivered to the lungs and brain activity. This is important because really sick patients receive breathing assistance using breathing machines to keep their oxygen levels within a normal range. Although these machines are life-saving tools, they might result in brain cell injury, leading to cognitive impairment. So, establishing the existence of a physiological communication between the volume of air delivered using these breathing machines and brain activity is the first step to investigating therapies to prevent brain cell injury due to the use of breathing machines to assist breathing.
Demonstration of a physiological relationship between tidal volume set on the ventilator and hippocampal activity measured as changes in blood-oxygenation level-dependent (BOLD) in the regions of interest (ROIs). The results from this pilot study might assist in creating the foundation for explaining the mechanism of action of ventilation-associated brain injury. Mechanically ventilated patients who are undergoing MRI examinations under general anesthesia in isocapnic and isoxic conditions will have brain activity investigated under two different tidal volumes, 6 ml/kg and 12 ml/kg applied for 3-5 minutes. Positive end-expiratory pressure will be adjusted to maintain plateau pressure <30 cm H2O. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04105751 -
Testing a Novel Manual Communication System for Mechanically Ventilated ICU Patients
|
N/A | |
| Recruiting |
NCT04498598 -
Structural Modification In Supraglottic Airway Device
|
N/A | |
| Recruiting |
NCT05930678 -
Intubation of Obese Patients in the Operating Room With or Without Bag-Mask Ventilation
|
N/A | |
| Active, not recruiting |
NCT03266016 -
Real-time Effort Driven VENTilator Management
|
N/A | |
| Recruiting |
NCT05726877 -
Optimal PEEP in Pediatric Patients Under 17 Years of Age.
|
N/A | |
| Recruiting |
NCT05033730 -
Comparison Between VCV and FCV Through Ultra-thin Tube in Upper Airway Surgery
|
N/A | |
| Completed |
NCT06339073 -
CT-based Model for Predicting Prolonged Weaning in Patients With Abdominal Trauma
|
||
| Completed |
NCT03933332 -
Correlation Between Muscle Thickness and Inflammation With Ventilator Use in Critically Ill Patients
|
||
| Completed |
NCT03184974 -
Open Lung PEEP in Thoracic Surgery
|
N/A | |
| Recruiting |
NCT06270485 -
Influence of Positive-End-Expiratory-Pressure (PEEP) on Cardiac Output in Mechanically Ventilated Children
|
N/A | |
| Not yet recruiting |
NCT05383651 -
Post Market, Prospective Multicenter Observational Study of the Safety and Performance of Bellavista Ventilator
|
||
| Recruiting |
NCT05191433 -
Effects of Mechanical Ventilation on the Diaphragm in COVID-19 Intensive Care Patients. A Post-mortem Pathology Study
|
||
| Recruiting |
NCT04484727 -
"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"
|
||
| Recruiting |
NCT03439683 -
KAP Asynchrony Survey
|
||
| Completed |
NCT04733261 -
Diaphragmatic Mobility In Ventilated Assisted Patients
|
N/A | |
| Completed |
NCT03119935 -
Amflow-device Can Help Proper Ambu-bag Ventilation
|
N/A | |
| Completed |
NCT04744909 -
Navigation System for Percutaneous Tracheotomy
|
N/A | |
| Completed |
NCT03630003 -
Manually Operated Communication System
|
N/A | |
| Terminated |
NCT04657393 -
Ventilation in Cardiac Arrest
|
N/A | |
| Completed |
NCT03542747 -
Comparison of iLTS and LMA Fastrach in a Simulated Airway.
|
N/A |