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Clinical Trial Summary

The diaphragm is the fundamental muscle of the respiratory system. The diaphragmatic dysfunction is present in 60% of critical patients at hospital admission and up to 80% after prolonged mechanical ventilation and difficult weaning. Risk factors associated with diaphragm dysfunction and atrophy are sepsis, trauma, sedatives, steroids, and muscle relaxants. The main pathology characteristics of diaphragm biopsies of mechanically ventilated patients are atrophy and a reduction in contractility, determining an impact on the clinical outcome. Shi et al. found a higher section area of the diaphragm muscle fiber in biopsies of post mortem COVID-19 patients versus negative patients, independently from days of mechanical ventilation. The hypothesis of our study is to identify different clusters of pathological presentation in post-mortem COVID-19 mechanically ventilated patients.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

NCT number NCT05191433
Study type Observational
Source Azienda Sanitaria-Universitaria Integrata di Udine
Contact Luigi Vetrugno, MD
Phone + 39 0432559509
Email [email protected]
Status Recruiting
Start date November 1, 2020
Completion date January 20, 2022