Articulatory Adaptation Following Oral Cancer Treatment

Oral Cavity Squamous Cell Carcinoma Clinical Trial

— SPOKE  

Official title:

Speech Flexibility in Adulthood Following Oral Cancer Treatment: Acoustic and Kinematic Explorations

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05876247
• Other study ID #: METc 2021/711
• Status: Recruiting
• Start date: November 10, 2022
• Est. completion date: August 2025

Study information

• Verified date: May 2023
• Source: University Medical Center Groningen
• Contact: Thomas Tienkamp, MA
• Phone: +31 50 36 37051
• Email: t.b.tienkamp[@]umcg.nl
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this longitudinal study is to learn more about the articulatory consequences of surgical oral cancer treatment. The main aims are to study the coordination and development of speech articulation of patients who will undergo surgical treatment for oral cancer longitudinally and whether individual differences in the reliance on auditory or tactile information can predict the success of speech compensatory strategies.

Participants will perform multiple speech tasks while motion tracking sensors track the articulatory gestures.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: August 2025
• Est. primary completion date: August 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Diagnosed with T1 or T2 tumor in the oral cavity

2. At least 18 years old and able to provide informed consent

3. Native speaker of Dutch

4. Has nog been treated for oral cancer before

Exclusion Criteria:

1a. Recurrence of disease (for patients)

1b. Treated for oral cancer (for healthy controls) 2. Speech problems (e.g., stuttering) 3. Problems with sight or hearing that impede reading or understanding instructions. When glasses or a hearing aid resolve these problems, then participants are not excluded.

4. Neurological or psychological disorders (e.g., stroke) 5. Non-removable metal in, on or around the head (piercings, braces, pacemaker, electrodes) 6. Self-reported signs of depression

Related Conditions & MeSH terms

• Mouth Neoplasms
• Oral Cavity Squamous Cell Carcinoma
• Speech Disorders
• Squamous Cell Carcinoma of Head and Neck

Intervention

Other:
• Electromagnetic Articulography
Motion tracking sensors will track articulatory movements of the tongue, jaw and lips

Locations

Country	Name	City	State
Netherlands	Faculty of Arts, University of Groningen	Groningen
Netherlands	University Medical Centre Groningen	Groningen

Sponsors (1)

Lead Sponsor	Collaborator
University Medical Center Groningen

Country where clinical trial is conducted

Netherlands, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Articulatory gestures	Articulatory movements in three dimensions of the tongue, lips and jaw as measured by the NDI Vox Electromagnetic Articulograph. Measures include: articulator speed (mm/s), total displacement (mm), coordinates (x,y,z) during specific gestures.	2022-2025
Primary	Acoustic outcomes	Speech acoustics will be measured in Praat and include the first and second formants of vowels (in Hz), global movement size in terms of acoustic working space (Hz-squared), and the centre of gravity of sibilants (in Hz)	2022-2025