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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05629832
Other study ID # Ptp right ventricle protection
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date January 1, 2023
Est. completion date December 31, 2025

Study information

Verified date April 2024
Source Beijing Chao Yang Hospital
Contact Xiao Tang, MD
Phone +86013811089795
Email tangxiao0928@163.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.


Recruitment information / eligibility

Status Recruiting
Enrollment 40
Est. completion date December 31, 2025
Est. primary completion date December 31, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - duration of invasive mechanical ventilation less than 72 hours; - meet the diagnostic criteria of Berlin definition for ARDS; - age older than 18 Exclusion Criteria: - esophageal surgery or damage; - cardiac surgery; - severe bronchopleural fistula; - serious arrhythmia; pneumothorax; - tricuspid stenosis; - heparin allergy; - chronic pulmonary heart disease

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
mechanical ventilation strategy guided by transpulmonary pressure
Mechanical ventilation parameters adjust guided by transpulmonary pressure monitoring. For pressure assist control or volumn assit control mode; inspiratory pressure or volumn setting needs to maintain Ppeak less than 25 cm H2O; PEEP was set at such a level that expiratory Ptp stayed between 0 and 5 cm H2O.

Locations

Country Name City State
China Beijing Chao-Yang Hospital Beijing Beijing

Sponsors (1)

Lead Sponsor Collaborator
Beijing Chao Yang Hospital

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Pulmonary vascular resistance (PVR) PVR will measured by Swan-Ganz catheter 3 days
Primary Pulmonary vascular compliance Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter. 3 days
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