Acute Respiratory Distress Syndrome Clinical Trial
Official title:
Transpulmonary Pressure Guided Mechanical Ventilation Strategy for Right Ventricle Protection in Acute Respiratory Distress Syndrome
To compare the effect between mechanical ventilation strategy guided by transpulmonary pressure and tranditional lung protective ventilation strategy in acute respiratory distress syndrome for right ventricle protection.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | December 31, 2025 |
Est. primary completion date | December 31, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - duration of invasive mechanical ventilation less than 72 hours; - meet the diagnostic criteria of Berlin definition for ARDS; - age older than 18 Exclusion Criteria: - esophageal surgery or damage; - cardiac surgery; - severe bronchopleural fistula; - serious arrhythmia; pneumothorax; - tricuspid stenosis; - heparin allergy; - chronic pulmonary heart disease |
Country | Name | City | State |
---|---|---|---|
China | Beijing Chao-Yang Hospital | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Beijing Chao Yang Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pulmonary vascular resistance (PVR) | PVR will measured by Swan-Ganz catheter | 3 days | |
Primary | Pulmonary vascular compliance | Pulmonary vascular compliance will be calculated using pulmonary artery pressure divided by stroke output measured by Swan-Ganz catheter. | 3 days |
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