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Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT05581303
Other study ID # 20180244
Secondary ID
Status Active, not recruiting
Phase Phase 3
First received
Last updated
Start date December 14, 2022
Est. completion date December 29, 2026

Study information

Verified date April 2024
Source Amgen
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The primary objective of this study is to compare the effect of treatment with olpasiran, to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants with atherosclerotic cardiovascular disease (ASCVD) and elevated Lipoprotein(a).


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 7297
Est. completion date December 29, 2026
Est. primary completion date December 29, 2026
Accepts healthy volunteers No
Gender All
Age group 18 Years to 85 Years
Eligibility Inclusion Criteria: - Age 18 to = 85 years - Lp(a)= 200 nmol/L during screening - History of ASCVD as evidenced by history of either: - Myocardial infarction (presumed type 1 event due to plaque rupture/erosion) and/or - Coronary revascularization with percutaneous coronary intervention AND at least 1 additional risk factor. Exclusion Criteria: - Severe renal dysfunction - Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 3 x upper limit of normal (ULN), or total bilirubin (TBL) > 2 x ULN during screening - History of hemorrhagic stroke - History of major bleeding disorder - Planned cardiac surgery or arterial revascularization - Severe heart failure - Current, recent, or planned lipoprotein apheresis - Previously received ribonucleic acid therapy specifically targeting Lp(a)

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
Placebo
Placebo given by subcutaneous injection once every 12 weeks (Q12W).
Olpasiran
Olpasiran given by subcutaneous injection Q12W.

Locations

Country Name City State
Argentina Instituto de Investigaciones Clinicas Bahia Blanca Bahia Blanca Buenos Aires
Argentina Clinica Adventista Belgrano Buenos Aires
Argentina Cedic Centro de Investigacion Clinica Caba Buenos Aires
Argentina Cemedic Centro de Especialidades Medicas Caba Buenos Aires
Argentina Centro Medico Dra Laura Maffei Investigacion Clinica Aplicada Caba Buenos Aires
Argentina Cinme - Centro de Investigaciones Metabolicas Caba Buenos Aires
Argentina Ciprec Centro de Investigacion y Prevencion Cardiovascular Caba Buenos Aires
Argentina Consultorio Medico Dr Litvak Bruno Caba Buenos Aires
Argentina Consultorios Medicos Dr Besada Caba Buenos Aires
Argentina Fundacion Respirar - Consultorios Medicos Dr Doreski Caba Buenos Aires
Argentina Fundacion Favaloro Ciudad Autonoma de Buenos Aires Buenos Aires
Argentina Glenny Corp SA Ciudad Autonoma de Buenos Aires Buenos Aires
Argentina Icba Instituto Cardiovascular de Buenos Aires Ciudad Autonoma de Buenos Aires Buenos Aires
Argentina Clinica Privada del Prado Cordoba Córdoba
Argentina Instituto de Investigaciones Clinicas de Cordoba Cordoba Córdoba
Argentina Instituto Latinoamericano de Investigaciones Medicas Cidim-Ilaim Cordoba Córdoba
Argentina Instituto Medico Damic Córdoba
Argentina Hospital Italiano de Buenos Aires Cuidad Autonoma de Buenos Aires Buenos Aires
Argentina Ciad - Consultorio Integral de Atencion al Diabetico Moron Buenos Aires
Argentina Instituto de Investigaciones Clinicas Quilmes Srl Quilmes Buenos Aires
Argentina Instituto de Investigaciones Clinicas Rosario Rosario Santa Fe
Argentina Instituto de Investigaciones Clinicas de San Nicolas San Nicolas Buenos Aires
Argentina Centro de Investigaciones Clinicas del Litoral Santa Fe
Argentina Clinica Fusavim Privada SRL Villa Maria Córdoba
Argentina Instituto de Investigaciones Clinicas Zarate Zarate Buenos Aires
Australia Nightingale Research Adelaide South Australia
Australia Advara HeartCare Wesley Auchenflower Queensland
Australia Flinders Medical Centre Bedford Park South Australia
Australia Advara HeartCare Berwick Berwick Victoria
Australia Advara HeartCare Bundaberg Bundaberg Queensland
Australia Royal Prince Alfred Hospital Camperdown New South Wales
Australia Victorian Heart Hospital Clayton Victoria
Australia Concord Repatriation General Hospital Concord New South Wales
Australia The Cardiologists Proprietary Limited Epping Victoria
Australia Canberra Hospital Garran Australian Capital Territory
Australia Barwon Health Geelong Hospital Geelong Victoria
Australia Royal Brisbane and Womens Hospital Herston Queensland
Australia Royal Hobart Hospital Hobart Tasmania
Australia Advara HeartCare Joondalup Joondalup Western Australia
Australia Advara HeartCare Leabrook Leabrook South Australia
Australia Liverpool Hospital Liverpool New South Wales
Australia Core Research Group Pty Ltd Milton Queensland
Australia Mount Hospital Murdoch Western Australia
Australia Linear Clinical Research Limited Nedlands Western Australia
Australia Advara HeartCare Ringwood Ringwood Victoria
Australia Holdsworth House Medical Practice Sydney New South Wales
Australia Wollongong Hospital Wollongong New South Wales
Australia Dr Heart Pty Ltd Woolloongabba Queensland
Austria Landeskrankenhaus Feldkirch Feldkirch
Austria Medizinische Universitaet Graz Graz
Austria Klinikum Klagenfurt am Woerthersee Klagenfurt
Austria Krankenhaus der Barmherzigen Brueder Linz Linz
Austria Landeskrankenhaus Salzburg Salzburg
Austria Universitaetsklinikum Sankt Poelten Sankt Poelten
Austria Klinik Hietzing Wien
Austria Klinik Landstrasse Wien
Austria Klinik Ottakring Wien
Austria Krankenhaus Nord - Klinik Floridsdorf Wien
Austria Universitaetsklinikum Allgemeines Krankenhaus Wien Wien
Belgium Algemeen Stedelijk Ziekenhuis Aalst Aalst
Belgium Onze Lieve Vrouw Ziekenhuis - campus Aalst Aalst
Belgium Ziekenhuisnetwerk Antwerpen site Cadix Antwerpen
Belgium Cliniques universitaires de Bruxelles Hopital Erasme Brussels
Belgium Algemeen Ziekenhuis Sint Blasius Dendermonde
Belgium Universitair Ziekenhuis Antwerpen Edegem
Belgium Ziekenhuis Oost-Limburg - Campus Sint-Jan Genk
Belgium Algemeen Ziekenhuis Sint Lucas Gent
Belgium Jessa Ziekenhuis - Campus Virga Jesse Hasselt
Belgium Universitair Ziekenhuis Leuven - Campus Gasthuisberg Leuven
Belgium Centre Hospitalier Regional de la Citadelle Liège
Belgium Algemeen Ziekenhuis Sint-Maarten Mechelen
Belgium Algemeen Ziekenhuis Turnhout Turnhout
Brazil jmf Clinica do Coracao ltda Aracaju Sergipe
Brazil AngioCor Blumenau Blumenau Santa Catarina
Brazil Associacao de Amparo a Saude Ensino e Pesquisa Brasília Distrito Federal
Brazil Instituto de Pesquisa Clínica de Campinas Campinas São Paulo
Brazil Loema Instituto de Pesquisa Clinica e Consultores Ltda Campinas São Paulo
Brazil Hospital Universitario Maria Aparecida Pedrossian Campo Grande Mato Grosso Do Sul
Brazil Nucleo de Pesquisa Clinica Curitiba Paraná
Brazil Quanta Diagnostico por Imagem Curitiba Paraná
Brazil Centro de Pesquisas em Diabetes e Doencas Endocrino Metabolicas Fortaleza Ceará
Brazil Hospital Universitario Walter Cantidio Fortaleza Ceará
Brazil Hospital das Clinicas da Universidade Federal de Goias Goiania Goiás
Brazil icm Instituto do Coração de Marilia Marilia São Paulo
Brazil Instituto Atena de Pesquisa Clínica Natal Rio Grande Do Norte
Brazil Centro de Pesquisa Clínica Associação Hospitalar Moinhos de Vento Porto Alegre Rio Grande Do Sul
Brazil FZ Pesquisa e Servicos em Cardiologia LTDA Porto Alegre Rio Grande Do Sul
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Brazil Hospital Sao Francisco da Santa Casa de Misericordia de Porto Alegre Porto Alegre Rio Grande Do Sul
Brazil Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul Porto Alegre Rio Grande Do Sul
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Brazil Instituto de Cardiologia do Rio Grande do Sul Porto Alegre Rio Grande Do Sul
Brazil Nucleo de Pesquisa Clinica do Rio Grande do Sul Porto Alegre Rio Grande Do Sul
Brazil Hospital Agamenon Magalhaes Recife Pernambuco
Brazil Procape Recife Pernambuco
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Brazil Fundacao Pro-Coracao Rio de Janeiro
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Brazil Hospital de Base de Sao Jose do Rio Preto Sao Jose do Rio Preto São Paulo
Brazil Instituto Dante Pazzanese de Cardiologia Sao Paulo São Paulo
Brazil Instituto de Pesquisa em Endocrinologia Clinica IPEC Sao Paulo São Paulo
Brazil Instituto do Coracao do Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo Sao Paulo São Paulo
Brazil Sociedade Beneficente de Senhoras Hospital Sirio Libanes Sao Paulo São Paulo
Brazil Centro Paulista de Investigacoes Clinicas Cepic São Paulo
Brazil Eurolatino Pesquisas Medicas Uberlandia Minas Gerais
Brazil Centro do Diagnostico e Pesquisa da Osteoporose do Espirito Santo Vitória Espírito Santo
Brazil Integral Pesquisa e Ensino Votuporanga São Paulo
Bulgaria Multiprofile Hospital for Active Treatment Puls AD Blagoevgrad
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Bulgaria Acibadem City Clinic University Multiprofile Hospital for Active Treatment EOOD Sofia
Bulgaria Diagnostic-Consultative Center Ascendent OOD Sofia
Bulgaria Medical Center Kalimat EOOD Sofia
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Bulgaria Multiprofile Hospital for Active Treatment National Hospital of Cardiology EAD Sofia
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Canada One Heart Care Mississauga Ontario
Canada Institut de recherches cliniques de Montreal Montreal Quebec
Canada Research Institute of McGill University Health Center - Glen Site Montreal Quebec
Canada North York Diagnostic and Cardiac Centre North York Ontario
Canada Oakville Cardiovascular Research Oakville Ontario
Canada Clinique des Maladies Lipidiques de Quebec Incorporated Quebec
Canada Institut Universitaire de cardiologie et de pneumologie de Quebec Quebec
Canada Centre Hospitalier Universitaire de Quebec, Centre Hotel-Dieu de Quebec Québec Quebec
Canada Centre de sante et de services sociaux du Nord de Lanaudiere St-Charles-Borromee Quebec
Canada Womens College Hospital Toronto Ontario
Canada ARC Biosystems Incorporated Vancouver British Columbia
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Denmark Rigshospitalet Copenhagen O
Denmark Sydvestjysk Sygehus Esbjerg
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Denmark Herlev Gentofte Hospital Herlev
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Denmark Regionshospitalet Gødstrup Herning
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Denmark University of Fredriksberg Hospital Kobenhavn NV
Denmark Amager Hospital Kobenhavn S
Denmark Sjaellands Universitetshospital, Roskilde Roskilde
Denmark Slagelse Sygehus Slagelse
Denmark Svendborg Sygehus Svendborg
Denmark Sanos Vejle Vejle
Denmark Regionshospitalet Viborg Viborg
Estonia Center for Clinical and Basic Research Tallinn Tallinn
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Estonia North Estonia Medical Centre Foundation Tallinn
Estonia Tartu University Hospital Tartu
Finland Helsinki University Central Hospital Helsinki
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Finland Tampere University Hospital Tampere
Finland Suomen Terveystalo Oy Turku
France Centre Hospitalier Regional Universitaire de Besancon, Hopital Jean Minjoz Besancon cedex
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Germany Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin Berlin
Germany Charite - Universitaetsmedizin Berlin, Campus Virchow Berlin
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Hong Kong Queen Mary Hospital Hong Kong
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Mexico Fundacion Cardiovascular de Aguascalientes AC Aguascalientes
Mexico Hospital Cardiologica Aguascalientes Aguascalientes
Mexico Scientia Investigacion Clinica SC Chihuahua
Mexico Procliniq Investigacion Clinica Ciudad de México
Mexico Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada SC Culiacan Sinaloa
Mexico Virgen Cardiovascular Research SC Guadalajara Jalisco
Mexico Eukarya PharmaSite Monterrey Nuevo León
Mexico Consultorio de Medicina Especializada del Sector Privado Xalapa Veracruz
Netherlands Meander Medisch Centrum Amersfoort
Netherlands Academisch Medisch Centrum Amsterdam
Netherlands Onze Lieve Vrouwe Gasthuis Amsterdam
Netherlands Gelre Ziekenhuizen Apeldoorn
Netherlands Rijnstate Ziekenhuis Arnhem
Netherlands Bravis ziekenhuis, locatie Roosendaal Bergen op Zoom
Netherlands Amphia ziekenhuis Breda
Netherlands Reinier de Graaf Gasthuis Delft
Netherlands Haaglanden MC Den Haag
Netherlands Deventer Ziekenhuis Deventer
Netherlands Catharina Ziekenhuis Eindhoven
Netherlands Maxima Medisch Centrum Eindhoven
Netherlands Medisch Spectrum Twente Enschede
Netherlands Admiraal de Ruyter Ziekenhuis Goes
Netherlands Groene Hart Ziekenhuis Gouda
Netherlands Martini Ziekenhuis Groningen
Netherlands Zuyderland Medisch Centrum Heerlen
Netherlands Spaarne Gasthuis, locatie Haarlem Zuid Hoofddorp
Netherlands Dijklander Ziekenhuis Hoorn Hoorn
Netherlands Leids Universitair Medisch Centrum Leiden
Netherlands Alrijne Ziekenhuis Leiderdorp
Netherlands Radboud Universitair Medisch Centrum Nijmegen
Netherlands Erasmus Medisch Centrum Rotterdam
Netherlands D and A Research and Genetics Sneek
Netherlands Haga Ziekenhuis The Hague
Netherlands Ziekenhuis Rivierenland Tiel
Netherlands Elisabeth-TweeSteden Ziekenhuis Tilburg
Netherlands Universitair Medisch Centrum Utrecht Utrecht
Netherlands VieCuri Medisch Centrum Venlo
Norway Oslo Universitetssykehus HF Aker sykehus Oslo
Norway Oslo Universitetssykehus HF, Aker sykehus Oslo
Norway Skedsmo Medisinske senter Skedsmokorset
Poland American Heart of Poland Spolka Akcyjna Belchatow
Poland American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca Bielsko-Biala
Poland American Heart of Poland Spolka Akcyjna Chrzanow
Poland American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca Dabrowa Gornicza
Poland Uniwersyteckie Centrum Kliniczne Gdansk
Poland NZOZ Medica Jerzy Cygler Gizycko
Poland American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca Kedzierzyn Kozle
Poland Jaroslaw Ciosek Rajtar-Medica Centrum Medyczne Krakow
Poland Wojewodzki Specjalistyczny Szpital im dr Wladyslawa Bieganskiego w Lodzi Lodz
Poland Miedziowe Centrum Zdrowia SA Lubin
Poland CenterMed Spzoo Centermed Lublin Lublin
Poland Clinical Best Solutions Sp zoo Spolka Komandytowa Gabinet Lekarski Lublin
Poland NZOZ Twoja Przychodnia Spzoo Twoja Przychodnia Spzoo Lublin
Poland Uniwersyteckie Centrum Stomatologii I Medycyny Specjalistycznej Spolka z ograniczona odpowiedzialnos Poznan
Poland KO-MED Centra Kliniczne Sp zoo KO-MED Centra Kliniczne Pulawy Pulawy
Poland American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca Sztum
Poland American Heart of Poland Spolka Akcyjna Polsko-Amerykanskie Kliniki Serca Tychy
Poland FutureMeds Warszawa Centrum Warszawa
Poland Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy Warszawa
Poland Szpital Grochowski imienia Doktora medycyny Rafala Masztaka Spzoo Warszawa
Poland Futuremeds spolka z ograniczona odpowiedzialnoscia Wroclaw
Poland Slaskie Centrum Chorob Serca w Zabrzu Zabrze
Poland KO-MED Centra Kliniczne Zamosc Zamosc
Poland American Heart of Poland Spolka Akcyjna Zgierz
Portugal Hospital Garcia de Orta, EPE Almada
Portugal Hospital Professor Doutor Fernando Fonseca, EPE Amadora
Portugal Centro Hospitalar do Baixo Vouga, EPE - Hospital Infante Dom Pedro Aveiro
Portugal Hospital de Braga, EPE Braga
Portugal Centro Hospitalar de Lisboa Ocidental, EPE - Hospital de Santa Cruz Carnaxide
Portugal Hospital de Cascais Cascais
Portugal Centro Hospitalar e Universitario de Coimbra EPE Coimbra
Portugal Hospital da Senhora da Oliveira Guimaraes, EPE Guimaraes
Portugal Unidade Local de Saude de Matosinhos - Hospital Pedro Hispano Matosinhos
Portugal Centro Hospitalar Universitario do Porto, EPE - Hospital de Santo Antonio Porto
Portugal Centro Hospitalar de Entre o Douro e Vouga, EPE - Unidade de Sao Sebastiao Santa Maria da Feira
Portugal Centro Hospitalar de Setubal EPE Hospital de Sao Bernardo Setubal
Portugal Centro Hospitalar de Vila Nova de Gaia/Espinho EPE Vila Nova de Gaia
Romania cmi Cardiologie - Dr Mercea Corina Delia Baia Mare
Romania Spitalul Universitar de Urgenta Bucuresti Bucharest
Romania Spitalul Clinic Universitar de Urgenta Elias Bucuresti
Romania Matcord Biomedica Buzau Buzau
Romania SC Sal Med SRL Pitesti
Romania Cardio Med Medical Center Targu Mures Targu Mures
Romania Spitalul Clinic Judetean de Urgenta Targu Mures Targu-Mures
Romania Spitalul Clinic Municipal de Urgenta Timisoara Timisoara
Slovakia Alian, sro Bardejov
Slovakia Kardiovita sro Bratislava
Slovakia Narodny ustav srdcovych a cievnych chorob, as Bratislava
Slovakia Nemocnica s poliklinikou Brezno, no Brezno
Slovakia Intergal, sro Klastor pod Znievom
Slovakia Cardio D and R, sro Kosice Kosice
Slovakia Medical group Kosice sro Kosice
Slovakia Zarmed, sro Kosice
Slovakia Kardio 1 sro Lucenec
Slovakia Medi M and M sro Moldava nad Bodvou
Slovakia Oralek, sro Namestovo
Slovakia Kardiocentrum Nitra sro Nitra
Slovakia Kardiomed NZ, sro Nove Zamky
Slovakia Medikard, sro Presov
Slovakia Medispol, sro Presov
Slovakia Medilex sro Rimavska Sobota
Slovakia Tatratrial sro Roznava
Slovakia Interna SK, sro Svidnik
Slovakia Areteus sro Trebisov
Slovakia CardiOr, sro Trencin
Spain Complexo Hospitalario Universitario A Coruña A Coruña Galicia
Spain Hospital Universitari Germans Trias i Pujol Badalona Cataluña
Spain Hospital Clinic i Provincial de Barcelona Barcelona Cataluña
Spain Hospital de la Santa Creu i Sant Pau Barcelona Cataluña
Spain Hospital del Mar Barcelona Cataluña
Spain Hospital Universitari Vall d Hebron Barcelona Cataluña
Spain Hospital Universitario Reina Sofia Cordoba Andalucía
Spain Hospital Universitario Virgen de la Arrixaca El Palmar Murcia
Spain Hospital de Cabueñes Gijon Asturias
Spain Hospital Universitari de Bellvitge Hospitalet de Llobregat Cataluña
Spain Hospital Universitario de Leon Leon Castilla León
Spain Hospital Clinico San Carlos Madrid
Spain Hospital Universitario 12 de Octubre Madrid
Spain Hospital Universitario Ramon y Cajal Madrid
Spain Hospital Clinico Universitario Virgen de la Victoria Malaga Andalucía
Spain Hospital de Sant Joan Despi Moises Broggi Sant Joan Despi Cataluña
Spain Hospital Universitario Virgen del Rocio Sevilla Andalucía
Spain Hospital Universitario Virgen Macarena Sevilla Andalucía
Spain Hospital Arnau de Vilanova de Valencia Valencia Comunidad Valenciana
Spain Hospital Clinico Universitario de Valencia Valencia Comunidad Valenciana
Spain Hospital Alvaro Cunqueiro Vigo Galicia
Spain Hospital Universitario Miguel Servet Zaragoza Aragón
Sweden Falu Lasarett Falun
Sweden Sahlgrenska Universitetssjukhuset Göteborg
Sweden Helsingborgs Lasarett Helsingborg
Sweden Clemenstorgets Hjartmottagning Lund
Sweden PharmaSite Malmo Malmo
Sweden Karolinska Universitetssjukhuset Huddinge Stockholm
Sweden Karolinska Universitetssjukhuset Solna Stockholm
Taiwan Hualien Tzu Chi Hospital Hualien
Taiwan Kaohsiung Medical University Chung-Ho Memorial Hospital Kaohsiung
Taiwan Mackay Memorial Hospital Tamsui Branch New Taipei
Taiwan Chung Shan Medical University Hospital Taichung
Taiwan Veterans General Hospital - Taichung Taichung
Taiwan National Cheng Kung University Hospital Tainan
Taiwan National Taiwan University Hospital Taipei
Taiwan Shin Kong Wu Ho-Su Memorial Hospital Taipei
Taiwan Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation Taoyuan
United Kingdom Ormeau Clinical Trials Ltd Belfast
United Kingdom Russell Hall Hospital Birmingham
United Kingdom NIHR Patient Recruitment Centre Blackpool Blackpool
United Kingdom NIHR Patient Recruitment Centre Bradford Bradford
United Kingdom West Walk Surgery Bristol
United Kingdom St Richards Hospital Chichester
United Kingdom Rowden Surgery Chippenham
United Kingdom Craigavon Area Hospital Craigavon
United Kingdom Panthera Biopartners - London Enfield
United Kingdom NIHR Patient Recruitment Centre Exeter Exeter
United Kingdom Panthera Biopartners - Glasgow Glasgow
United Kingdom Harefield Hospital Harefield
United Kingdom Wycombe General Hospital High Wycombe
United Kingdom Highlands Clinical Research Facility, Raigmore Hospital Inverness
United Kingdom NIHR Patient Recruitment Centre Leicester Leicester
United Kingdom Lincoln County Hospital Lincoln
United Kingdom Hammersmith Hospital London
United Kingdom Queen Mary University of London London
United Kingdom University Hospital Llandough Penarth
United Kingdom The Adam Practice Poole
United Kingdom Panthera Biopartners - Preston Preston
United Kingdom Lister Hospital Stevenage
United States Alaska Cardiovascular Research Foundation Anchorage Alaska
United States Northwest Heart Clinical Research LLC Arlington Heights Illinois
United States Asheville Cardiology Associates Asheville North Carolina
United States Morehouse School of Medicine Atlanta Georgia
United States Piedmont Healthcare Atlanta Georgia
United States Texas Diabetes and Endocrinology Austin Texas
United States Johns Hopkins University School of Medicine Baltimore Maryland
United States Maryland Cardiovascular Specialists Baltimore Maryland
United States University of Maryland Medical Center Baltimore Maryland
United States Northern Light Eastern Maine Medical Center Bangor Maine
United States Metropolitan Cardiovascular Consultants LLC Beltsville Maryland
United States National Heart Institute Beverly Hills California
United States Vitality Clinical Research Beverly Hills California
United States Ascension Saint Vincents Birmingham Birmingham Alabama
United States Grandview Medical Center Affinity Cardiovascular Specialists, LLC Birmingham Alabama
United States Excel Medical Clinical Trials Boca Raton Florida
United States Brigham and Womens Hospital Boston Massachusetts
United States Bay Area Cardiology Brandon Florida
United States Medical University of South Carolina Charleston South Carolina
United States Novant Health Heart and Vascular Institute Charlotte North Carolina
United States TriHealth Good Samaritan Hospital Cincinnati Ohio
United States Clearwater Cardiovascular Consultants Clearwater Florida
United States University Hospitals Cleveland Medical Center Cleveland Ohio
United States UCHealth Memorial Central Colorado Springs Colorado
United States Prisma Health Midlands Cardiology Columbia South Carolina
United States The OhioHealth Research Institute Columbus Ohio
United States New York Presbyterian Medical Group Hudson Valley Cardiology Cortlandt Manor New York
United States Saint Elizabeth Covington Covington Kentucky
United States Northeast Georgia Medical Center Wisteria Building Cumming Georgia
United States Baylor Scott and White Heart and Vascular Hospital-Dallas Dallas Texas
United States Southwest Family Medicine Associates Dallas Texas
United States Cardiology Associates Research LLC Daytona Beach Florida
United States Ascension Saint John Hospital Detroit Michigan
United States Henry Ford Hospital Detroit Michigan
United States Duke University Durham North Carolina
United States David Turbay, MD El Paso Texas
United States Northshore University Health System Evanston Illinois
United States Inova Heart and Vascular Institute Fairfax Virginia
United States Virginia Heart Falls Church Virginia
United States Lillestol Research LLC Fargo North Dakota
United States Jellinger and Lerman MD PA dba The Center for Diabetes and Endocrine Care Fort Lauderdale Florida
United States Piedmont Research Partners Fort Mill South Carolina
United States Care Access - Georgetown Georgetown Texas
United States Stern Cardiovascular Foundation Inc Germantown Tennessee
United States Advanced Cardiology Associates Grand Rapids Michigan
United States Healthy Heart Cardiology Grand Rapids Michigan
United States Moses H Cone Memorial Hospital Greensboro North Carolina
United States Louisiana Heart Center Hammond Louisiana
United States Elite Cardiac Research Center LLC Hialeah Florida
United States Baylor College of Medicine Houston Texas
United States Heart Center Research LLC Huntsville Alabama
United States East Coast Institute for Research LLC Jacksonville Florida
United States East Coast Institute for Research, LLC Jacksonville Florida
United States Jacksonville Center for Clinical Research Jacksonville Florida
United States University of Florida Jacksonville Florida
United States Westside Center for Clinical Research Jacksonville Florida
United States Northside Clinical Research Johns Creek Georgia
United States University of Kansas Medical Center Kansas City Kansas
United States Kettering Medical Center Kettering Ohio
United States Elligo Health Research Kew Gardens New York
United States WMCHealth Heart and Vascular Institute Kingston Division of Cardiology Kingston New York
United States Texas Cardiology Associates of Houston Kingwood Texas
United States University of California San Diego La Jolla California
United States Care Access - Lake Charles Lake Charles Louisiana
United States Sparrow Clinical Research Institute Lansing Michigan
United States Palm Research Center Inc Las Vegas Nevada
United States Virginia Heart - Loudoun Leesburg Virginia
United States The Research Group of Lexington LLC Lexington Kentucky
United States Bryan Heart Lincoln Nebraska
United States VA Greater Los Angeles Healthcare System Los Angeles California
United States University of Louisville Health - Jewish Hospital Louisville Kentucky
United States Carient Heart and Vascular Manassas Virginia
United States Northwell Health Physician Partners Cardiology at Manhasset Manhasset New York
United States Fairview Health Services Maplewood Minnesota
United States Rama Research LLC Marion Ohio
United States Texas Institute of Cardiology McKinney Texas
United States St Lukes Idaho Cardiology Associates Meridian Idaho
United States Bon Secours Cardiology Midlothian Virginia
United States Minneapolis Heart Institute Foundation Minneapolis Minnesota
United States University of Minnesota Minneapolis Minnesota
United States Mobile Heart Specialists PC Mobile Alabama
United States Clinical Trials of America Inc Monroe Louisiana
United States Lapis Clinical Research Mooresville North Carolina
United States Cardiovascular Research of Northwest Indiana LLC Munster Indiana
United States Advanced Research for Health Improvement, LLC Naples Florida
United States Icahn School of Medicine at Mount Sinai New York New York
United States Icahn School of Medicine at Mount Sinai Queens New York New York
United States New York University Langone Health New York New York
United States Northwell Health Lenox Hill Heart and Vascular New York New York
United States Saint Michaels Medical Center Newark New Jersey
United States Capital Area Research LLC Newport Pennsylvania
United States Tidewater Physicians Multispecialty Group Clinical Research Newport News Virginia
United States Ocala Cardiovascular Research Ocala Florida
United States Permian Research Foundation Odessa Texas
United States University of California Irvine Orange California
United States AdventHealth Medical Group Cardiology at Orlando Orlando Florida
United States Midwest Heart and Vascular Specialists Overland Park Kansas
United States Advocate Lutheran General Hospital Park Ridge Illinois
United States Montefiore Medical Center - Bronx Philadelphia Pennsylvania
United States University of Pennsylvania Philadelphia Pennsylvania
United States Elite Clinical Studies LLC Phoenix Arizona
United States Allegheny General Hospital Pittsburgh Pennsylvania
United States Oregon Health and Science University Portland Oregon
United States Pulse Heart Institute Puyallup Washington
United States Monument Health Clinical Research Rapid City South Dakota
United States Renown Institute for Heart and Vascular Health Reno Nevada
United States Reid Physician Associates Richmond Indiana
United States Northwell Health Physician Partners at Peconic Riverhead New York
United States Mayo Clinic Rochester Rochester Minnesota
United States East Coast Institute for Research, LLC Saint Augustine Florida
United States Saint Johns Center for Clinical Research Saint Augustine Florida
United States Saint Louis Heart and Vascular PC Saint Louis Missouri
United States TidalHealth Peninsula Regional, Inc Salisbury Maryland
United States University of California Los Angeles Santa Monica California
United States Cardiovascular Center of Sarasota Sarasota Florida
United States HonorHealth Research and Innovation Institute Scottsdale Arizona
United States Cardiology Associates of Fairfield County PC Stamford Connecticut
United States Manshadi Heart Institute Stockton California
United States Stony Brook University Hospital Stony Brook New York
United States Overlook Medical Center Summit New Jersey
United States Care Access - Tampa Tampa Florida
United States Med Partners, Inc dba Premiere Medical Center, Inc Toluca Lake California
United States Northwest Houston Heart Center Tomball Texas
United States Arcturus Healthcare, Public Limited Company, Troy Internal Medicine Research Division Troy Michigan
United States Tennessee Center for Clinical Trials Tullahoma Tennessee
United States Cardiology Associates Research LLC Tupelo Mississippi
United States Westchester Medical Center Valhalla New York
United States MedStar Clinical Research Washington District of Columbia
United States MercyOne Iowa Heart Center West Des Moines Iowa
United States Monroe Research LLC West Monroe Louisiana
United States Winchester Cardiology and Vascular Medicine Winchester Virginia
United States Wake Forest University Health Sciences Winston-Salem North Carolina
United States NY Family Docs Woodhaven New York

Sponsors (1)

Lead Sponsor Collaborator
Amgen

Countries where clinical trial is conducted

United States,  Argentina,  Australia,  Austria,  Belgium,  Brazil,  Bulgaria,  Canada,  China,  Czechia,  Denmark,  Estonia,  Finland,  France,  Germany,  Greece,  Hong Kong,  Hungary,  Iceland,  Italy,  Japan,  Korea, Republic of,  Lithuania,  Mexico,  Netherlands,  Norway,  Poland,  Portugal,  Romania,  Slovakia,  Spain,  Sweden,  Taiwan,  United Kingdom, 

Outcome

Type Measure Description Time frame Safety issue
Primary Time to CHD death, myocardial infarction, or urgent coronary revascularization, whichever occurs first Approximately 4 years
Secondary Time to cardiovascular death, myocardial infarction, or ischemic stroke, whichever occurs first Approximately 4 years
Secondary Time to cardiovascular death, myocardial infarction, urgent coronary revascularization, or ischemic stroke, whichever occurs first Approximately 4 years
Secondary Percent change from baseline to Week 48 in Lipoprotein(a) Baseline and Week 48
Secondary Time to myocardial infarction Approximately 4 years
Secondary Time to CHD death or myocardial infarction, whichever occurs first Approximately 4 years
Secondary Time to urgent coronary revascularization Approximately 4 years
Secondary Time to coronary revascularization Approximately 4 years
Secondary Time to CHD death Approximately 4 years
Secondary Time to cardiovascular death Approximately 4 years
Secondary Time to death by any cause Approximately 4 years
Secondary Time to ischemic stroke Approximately 4 years
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