Functional Magnetic Resonance Imaging Clinical Trial
Official title:
High Definition Transcranial Alternating Current Stimulation (HD-tACS) for Post-stroke Aphasia
To investigate the intervention effect of high definition transcranial alternating current stimulation(HD-tACS) in chronic post-stroke aphasia and its underlying neural mechanism by MRI.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | December 30, 2023 |
Est. primary completion date | December 30, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion Criteria: - aphasia diagnosed by the ABC. - 18-75 years old. - native Chinese speaker. - right-handed. - post onset of stroke =6months. Exclusion Criteria: - mental illness . - severe dysarthria. - a history of head injury or surgery. - alcohol or substance abuse. - cerebral tumor or abscess. |
Country | Name | City | State |
---|---|---|---|
China | Anhui Medical University | Hefei |
Lead Sponsor | Collaborator |
---|---|
Anhui Medical University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | language function | Language deficit was assessed by the same professional language therapist using the Aphasia Battery of Chinese (ABC). The multidimensional test contains four subtypes, including spontaneous speech (semi-standardized interview, assessment of the fluency, and information of speech; total score 20 points), auditory comprehension (yes or no question, auditory picture matching task, and verbal instruction; total score 230 points), repetition (words and sentences; total score 100 points), and naming (simple objects, colors, pictures, and situations; total score 80 points). The combined score is used to calculate an aphasia quotient (AQ) reflecting the overall severity of language impairment. Patients with AQ below 93.8 points were considered as aphasic. | baseline and immediately after intervention | |
Primary | resting-state functional connectivity | the change of resting-state functional connectivity strength between stimulated target and the whole brain areas will be measured by functional MRI. | baseline and immediately after intervention | |
Secondary | comprehension function | the change of comprehension dysfunction will be assessed by Token. Token is composed of six parts. Token scale scores range from 0 to 36 points. Lower scores indicate more severe comprehension dysfunction. | baseline and immediately after intervention | |
Secondary | MMSE(Mini Mental State Examination) | The full name of MMSE is mini-mental state examination, and the scale consists of 30 subject, include the following seven aspects: time orientation, place orientation,immediate memory,attention and calculation,delay memory,language, visual space.One point is awarded for each question correctly answered during MMSE evaluation. If subject give the wrong answer or don't know answe he/she awarded 0 score, scope of scale score of 0 to 30 points. The higher the score, the better. | baseline and immediately after intervention |
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