Non ST Segment Elevation Acute Coronary Syndrome Clinical Trial
Official title:
On-admission Low-dose Colchicine in Addition to Atorvastatin to Reduce Inflammation in Acute Coronary Syndrome
Since colchicine is known to have anti-inflammatory effects and inflammation is an early component of acute coronary syndrome (ACS), this study aims to evaluate the acute effects of low-dose colchicine, in addition to atorvastatin, administered on-admission to statin-naive patients with non-ST elevation ACS scheduled for early invasive strategy.
On-admission all statin naive NSTEACS patients are randomized to receive either standard treatment of atorvastatin 80 mg or standard treatment plus colchicine (1 mg loading dose followed by 0.5 mg/day). Inflammatory biomarker high sensitivity C reactive protein (hs-CRP) is measured in all patients on-admission and every 24 hours thereafter until discharge. Cardiac and renal function parameters are evaluated to evidence the possible beneficial effects of the administration of colchicine in addition to atorvastatin alone both short- and medium-term (up to 30 days). Colchicine tolerance is also investigated through monitoring for clinical side effects. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02892903 -
In the Management of Coronary Artery Disease, Does Routine Pressure Wire Assessment at the Time of Coronary Angiography Affect Management Strategy, Hospital Costs and Outcomes?
|
N/A | |
| Recruiting |
NCT05117866 -
Acetyl Salicylic Elimination Trial JAPAN: The ASET JAPAN Pilot Study
|
N/A | |
| Recruiting |
NCT02578537 -
COmparison of the Pharmacodynamics and Pharmacokinetics Ticagrelor Versus Clopidogrel in Patients With CKD and NSTE-ACS
|
Phase 4 | |
| Recruiting |
NCT06051110 -
Individual Patient Data Meta-analysis on Prehospital Risk Assessment in Patients Suspected of Non-ST-segment Elevation Acute Coronary Syndrome
|
N/A | |
| Withdrawn |
NCT03300167 -
Study of the Vascular Response to Percutaneous Coronary Intervention in Patients With Non-ST-elevation Acute Coronary Syndromes Using Intravascular Blood Sampling
|
N/A | |
| Terminated |
NCT02071966 -
Study of Effects of Ticagrelor on Microparticles and Micro-RNA in NSTE-ACS
|
Phase 4 | |
| Not yet recruiting |
NCT06096909 -
Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population
|
N/A | |
| Recruiting |
NCT05125276 -
Less Bleeding by Omitting Aspirin in Non-ST-segment Elevation Acute Coronary Syndrome Patients
|
Phase 4 | |
| Recruiting |
NCT03863327 -
EKG Criteria and Identification of Acute Coronary Occlusion
|
||
| Completed |
NCT04400500 -
Differential Diagnosis and Risk Stratification in Patients With Suspected NSTEACS
|
||
| Completed |
NCT01962428 -
Different LD of Ticagrelor for Antiplatelet Effect in Patients With Non-ST-segment Elevation ACS Undergoing PCI
|
Phase 4 | |
| Recruiting |
NCT04476173 -
ANalgesic Efficacy and Safety of MOrphiNe Versus Methoxyflurane in Patients With Acute Myocardial Infarction
|
Phase 3 | |
| Recruiting |
NCT06255678 -
Angio-based Final Functional Effect of PCI
|
||
| Not yet recruiting |
NCT06197724 -
MCG for Identification of Myocardial Ischemia in Suspected NSTE-ACS Patients
|
||
| Completed |
NCT02073565 -
HARMONEE - Japan-USA Harmonized Assessment by Randomized, Multi-Center Study of OrbusNEich's Combo StEnt
|
N/A | |
| Completed |
NCT04766437 -
Optical Coherence Tomography-Guided PCI With Single-Antiplatelet Therapy
|
Phase 2 | |
| Not yet recruiting |
NCT05202041 -
Non-IRA Functional Evaluation With AccuFFRangio in NSTE-ACS
|
N/A | |
| Recruiting |
NCT02415803 -
Safety and Efficacy of Low-Dose Ticagrelor in Chinese Patients With NSTE-ACS
|
Phase 3 | |
| Not yet recruiting |
NCT05779059 -
Prasugrel Or Ticagrelor De-escalation in NSTE-ACS
|
Phase 3 |