Atherosclerotic Cardiovascular Disease Clinical Trial
— PREVAILOfficial title:
Placebo Controlled, Double Blind, Randomized Cardiovascular Outcome Study to Evaluate the Effect of 10 mg Obicetrapib in Participants With ASCVD Not Adequately Controlled Despite Maximally Tolerated Lipid Modifying Therapies
This study will be a placebo-controlled, double-blind, randomized, phase 3 study in participants with Atherosclerotic Cardiovascular Disease (ASCVD) who are not adequately controlled despite maximally tolerated lipid-lowering therapy.
| Status | Recruiting |
| Enrollment | 9000 |
| Est. completion date | November 2026 |
| Est. primary completion date | November 2026 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - Males & females = 18 years age. - Established ASCVD including: - Coronary artery disease - Cerebrovascular disease - Peripheral Artery disease - On maximally tolerated lipid-modifying therapy - Fasting LDL-C = 55 mg/dL - Fasting triglycerides < 400 mg/dL - Estimated glomerular filtration rate = 30 mL/min Exclusion Criteria: - New York Heart Association class III or IV heart failure or left ventricular ejection fraction < 30% - Have been hospitalized for Heart Failure within 5 years prior to screening - Had non-fatal MI, non-fatal stroke, non-elective coronary revascularization and/or hospitalization for unstable angina or chest pain within past 3 months prior to screening - Uncontrolled hypertension - Diagnosis of homozygous familial hypercholesterolemia (HoFH) - Active liver disease - HbA1c =10% - Thyroid Stimulating Hormone (TSH) > 1.5 times upper limit normal - Creatine kinase > 3 times upper limit normal - History of malignancy with surgery in past 3 years - History of alcohol or drug abuse within past 5 years - Received treatment with investigational product or device within past 30 days excluding Coronavirus treatment or vaccine - Known allergy to study drug - Participated in previous obicetrapib trial - Taking gemfibrozil within 30 days screening |
| Country | Name | City | State |
|---|---|---|---|
| Australia | Royal Adelaide Hospital | Adelaide | |
| Australia | Flinders Medical Centre | Bedford Park | |
| Australia | Campbelltown Hospital | Campbelltown | |
| Australia | The Prince Charles Hospital | Chermside | |
| Australia | Monash Health | Clayton | |
| Australia | Bridge Family Practice | Halls Creek | |
| Australia | Austin Health | Heidelberg | |
| Australia | Baker Heart and Diabetes Institute | Melbourne | |
| Australia | The Alfred Hospital | Melbourne | |
| Australia | Redcliffe Hospital | Redcliffe | |
| Australia | Western Health | Saint Albans | |
| Australia | Griffith University | Southport | |
| Australia | Wollongong Hospital (Illawarra Shoalhaven Local Health District) | Wollongong | |
| Australia | The Queen Elizabeth Hospital (TQEH) - SA Health | Woodville South | |
| Australia | Dr Heart Pty Ltd at Cholesterol Care Australia | Woolloongabba | |
| Bulgaria | MHAT Aytos EOOD Department of Internal Diseases | Aytos | |
| Bulgaria | Medical Center Doctor Staykov EOOD | Burgas | |
| Bulgaria | UMHAT Deva Maria | Burgas | |
| Bulgaria | Medical Center Viva Feniks | Dobrich | |
| Bulgaria | MHAT Sveti Ivan Rilski | Gorna Oryahovitsa | |
| Bulgaria | MHAT Haskovo AD | Haskovo | |
| Bulgaria | MHAT City Clinic - Sveti Georgi EOOD | Montana | |
| Bulgaria | Medical Center - Cordis OOD | Pleven | |
| Bulgaria | MHAT Heart and Brain Pleven | Pleven | |
| Bulgaria | Medical Center for Rehabilitation and Sports Medicine I - Plovdiv EOOD | Plovdiv | |
| Bulgaria | UMHAT Sveti Georgi EA | Plovdiv | |
| Bulgaria | Medical Center Rusemed EOOD | Ruse | |
| Bulgaria | SHATC Medica Cor EAD | Ruse | |
| Bulgaria | Multiprofile Hospital for Active Treatment (MHAT)- Silistra | Silistra | |
| Bulgaria | MHAT Dr. Ivan Seliminski AD | Sliven | |
| Bulgaria | "Medical Center Medic" OOD | Sofia | |
| Bulgaria | DCC "Ascendent" | Sofia | |
| Bulgaria | Diagnostic and Consulting Center 22 - Sofia | Sofia | |
| Bulgaria | Diagnostic consultative center 24 | Sofia | |
| Bulgaria | Diagnostic Consulting Center Convex EOOD | Sofia | |
| Bulgaria | MC Doctor Kalchev OOD | Sofia | |
| Bulgaria | Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD | Sofia | |
| Bulgaria | Medical Centre Medcross | Sofia | |
| Bulgaria | MHAT Sveta Sofia EOOD | Sofia | |
| Bulgaria | Multiprofile Hospital for Active Treatment National Cardiology Hospital | Sofia | |
| Bulgaria | National Multiprofile Transport Hospital Tsar Boris Treti - Cardiology Clinic | Sofia | |
| Bulgaria | CardioArt Medical Center | Stara Zagora | |
| Bulgaria | Medical Center Zara - Med | Stara Zagora | |
| Bulgaria | UMHAT Prof. Dr. Stoyan Kirkovich | Stara Zagora | |
| Bulgaria | Diagnostic Consultative Center Chaika | Varna | |
| Bulgaria | Medical Center Plazmamed Clinic | Varna | |
| Bulgaria | Specialized Hospital for Active Treatment of Cardiology | Varna | |
| Bulgaria | Medical Center Medica Plus OOD | Veliko Tarnovo | |
| Bulgaria | Medical Center Nevromedics | Veliko Tarnovo | |
| Bulgaria | Medical Center Velingrad 2017 EOOD | Velingrad | |
| Canada | Brampton Clinical Trials | Brampton | |
| Canada | Ecogene-21 | Chicoutimi | Quebec |
| Canada | LMC Diabetes & Endocrinology Ltd. - Thornhill | Concord | Ontario |
| Canada | Medical Arts Health Research Group - Kamloops | Kamloops | British Columbia |
| Canada | Centre de recherche clinique de Laval | Laval | |
| Canada | KMH Cardiology & Diagnostic Centres - Mississauga | Mississauga | |
| Canada | Medical Arts Health Research Group - North Vancouver | North Vancouver | British Columbia |
| Canada | Dr. James Cha | Oshawa | Ontario |
| Canada | The Medical Arts Health Research Group - Penticton | Penticton | British Columbia |
| Canada | Kawartha Cardiology Clinical Trials | Peterborough | Ontario |
| Canada | Institut Universitaire de Cardiologie et de Pneumologie De Quebec | Quebec | |
| Canada | CardioVasc HR | Saint-Jean-sur-Richelieu | Quebec |
| Canada | Centre intégré universitaire de santé et de services sociaux (CIUSSS) de l'Estrie -Centre hospitalier universitaire de Sherbrooke (CHUS) | Sherbrooke | Quebec |
| Canada | KMH Cardiology & Diagnostic Centres - Hamilton | Stoney Creek | Ontario |
| Canada | Diex Recherche Trois-Rivieres, Inc | Trois-Rivières | Quebec |
| Canada | Discovery Clinical Services, Ltd | Victoria | |
| Canada | Diex Recherche Victoriaville | Victoriaville | Quebec |
| Canada | Winnipeg Clinic | Winnipeg | Manitoba |
| China | Peking University First Hospital | Beijing | |
| China | The First Affiliated Hospital of Bengbu Medical College | Bengbu | |
| China | The First People's Hospital of Changde City | Changde | |
| China | The Second People's Hospital of Changzhou | Changzhou | |
| China | Affiliated Hospital of Chifeng University | Chifeng | |
| China | Daqing People's Hospital | Daqing | |
| China | Shunde Hospital of Southern Medical University | Foshan | |
| China | Guangdong Provincial People's Hospital | Guangzhou | |
| China | Heilongjiang Provincial Hospital | Harbin | |
| China | The First affiliated Hospital of Nanyang Medical College | Nanyang | |
| China | The First Affiliated Hospital of Nanyang Medical College - 2nd site | Nanyang | |
| China | Ningbo First Hospital | Ningbo | |
| China | Panjin Liaoyou Gem Flower Hospital | Panjin | |
| China | Pingxiang People's Hospital | Pingxiang | |
| China | People's Hospital of Tianjin | Tianjin | |
| China | Tianjin Fourth Central Hospital | Tianjin | |
| China | Xi'an Gaoxin Hospital | Xi'an | |
| China | Xianyang Hospital of Yan 'an University | Xianyang | |
| China | The Third Affiliatied Hospital of Xinxiang Medical University | Xinxiang | |
| China | Zibo City Linzi District People's Hospital | Zibo | |
| Croatia | General Hospital Karlovac | Karlovac | |
| Croatia | Special Hospital for Medical Rehabilitation Krapinske Toplice | Krapinske Toplice | |
| Croatia | General Hospital Dr Josip Bencevic | Slavonski Brod | |
| Croatia | Polyclinic Solmed | Zagreb | |
| Croatia | University Hospital Center Zagreb | Zagreb | |
| Czechia | Hornicka nemocnice s poliklinikou Bilina s.r.o. | Bílina | |
| Czechia | Medicus Services SRO | Brandýs Nad Labem | |
| Czechia | Amkardia sro | Brno | |
| Czechia | Centrum pro zdravi - kardiologie s.r.o. | Brno | |
| Czechia | Kardiologicka ambulance Brno s.r.o. | Brno | |
| Czechia | Nemocnice Havlickuv Brod, p.o. | Havlickuv Brod | |
| Czechia | Cevni ambulance - MATMED s.r.o. | Hodonin | |
| Czechia | MUDr. Tomas Edelsberger - diabetologicka ambulance | Krnov | |
| Czechia | Lunacor s.r.o. - Centrum pro choroby srdce a cev | Kromeríž | |
| Czechia | KARDIOLOGIE - LIBEREC s.r.o. | Liberec | |
| Czechia | InterKardio ML s.r.o. | Mariánské Lázne | |
| Czechia | Edumed s.r.o. | Náchod | |
| Czechia | PreventaMed s.r.o. | Olomouc | |
| Czechia | CCR Ostrava s.r.o. | Ostrava | |
| Czechia | Lunacor, s.r.o. - Centrum pro choroby srdce a cev - Otrokovice | Otrokovice | |
| Czechia | Kardiologie COR s.r.o. | Prague | |
| Czechia | Ustredni vojenska nemocnice | Prague | |
| Czechia | Fakultní nemocnice v Motole | Praha | |
| Czechia | Vseobecna fakultni nemocnice v Praze | Praha | |
| Czechia | Krajska nemocnice T. Bati | Zlín | |
| Denmark | Aalborg University Hospital | Aalborg | |
| Denmark | Amager Hospital | Copenhagen | |
| Denmark | Sydvestjysk Hospital | Esbjerg | |
| Denmark | Godstrup Regional Hospital (Gødstrup) | Herning | |
| Denmark | Bispebjerg Hospital | Kobenhavn | |
| Denmark | Viborg Regional Hospital | Viborg | |
| Finland | StudyCor Oy | Jyväskylä | |
| Finland | Satucon Oy Kuopio | Kuopio | |
| Finland | Turku University Hospital | Turku | |
| Georgia | Health Ltd | Batumi | |
| Georgia | JSC Evex Hospitals - Batumi Referral Hospital | Batumi | |
| Georgia | Kutaisi Primary Health Care Center #1 | Kutaisi | |
| Georgia | Bokhua Memorial Cardiovascular Center LTD | Tbilisi | |
| Georgia | Cardioclinic Digomi Medical Center- | Tbilisi | |
| Georgia | David Metreveli Medical Centre Lt | Tbilisi | |
| Georgia | Emergency Cardiology Center by Academician G. Chapidze Ltd | Tbilisi | |
| Georgia | JSC Curatio | Tbilisi | |
| Georgia | LTD Adapti | Tbilisi | |
| Georgia | Ltd Georgian-Dutch Hospital | Tbilisi | |
| Georgia | LTD Israeli -Georgian Medical Research Clinic Healthycore | Tbilisi | |
| Georgia | Ltd Tbilisi Heart Center | Tbilisi | |
| Georgia | LTD Vitamed | Tbilisi | |
| Georgia | Mediclub Georgia | Tbilisi | |
| Georgia | Multiprofile Clinic Consilium Medulla LTD | Tbilisi | |
| Georgia | National Center for Diabetes Research | Tbilisi | |
| Georgia | Tbilisi Heart and Vascular Clinic Ltd | Tbilisi | |
| Georgia | The First Medical Center LTD | Tbilisi | |
| Georgia | VivaMedi | Tbilisi | |
| Germany | Kardiologische Praxis Dr. med. univ. Wolfgang Jungmair | Bad Homburg | |
| Germany | Diabetespraxis Dr. Braun | Berlin | |
| Germany | Franziskus Hospital Berlin | Berlin | |
| Germany | kfgn | Site Operations & Services GmbH - Berlin-Mitte | Berlin | |
| Germany | Kardiologisch-Angiologische Praxis - Herzzentrum Bremen | Bremen | |
| Germany | MVZ am Küchwald GmbH | Chemnitz | |
| Germany | Gemeinschaftspraxis Diabeteszentrum Dortmund | Dortmund | |
| Germany | St Johannes Hospital Dortmund | Dortmund | |
| Germany | Kfgn | Site Operations & Services GmbH - Dresden | Dresden | |
| Germany | Universitaetsklinikum Carl Gustav Carus Dresden | Dresden | |
| Germany | ZKS - Zentrum Klinische Studien Sudbrandenburg GmbH | Elsterwerda | |
| Germany | Katholisches Krankenhaus St. Johann Nepomuk | Erfurt | |
| Germany | Klinisches Forschungszentrum Dr. Hagemann | Essen | |
| Germany | Studienzentrum Bocholderstrasse | Essen | |
| Germany | Zentrum für Klinische Studien (diabetes-falkensee.de) | Falkensee | |
| Germany | ClinPhenomics CVC GmbH | Frankfurt | |
| Germany | Diabeteszentrum Hamburg West (DZHW) / Gemeinschaftspraxis Dr. Wendisch, Dr. Dahl und Prof. Dr. Aberle | Hamburg | |
| Germany | St. Josefskrankenhaus Heidelberg GmbH | Heidelberg | |
| Germany | Universitaetsklinikum Schleswig-Holstein Campus Kiel | Kiel | |
| Germany | Velocity Clinical Research Leipzig GmBH | Leipzig | |
| Germany | Diabetologikum DDG Ludwigshafe | Ludwigshafen | |
| Germany | Kliniken Maria Hilf GmbH Krankenhaus St. Franziskus | Monchengladbach | |
| Germany | CDG Studienambulanz Dr. Hartard | München | |
| Germany | Klinikum München Klinik Neuperlach | München | |
| Germany | Praxis Drs. Haggenmiller/Jeserich | Nuernberg | |
| Germany | RED-Institut GmbH | Oldenburg In Holstein | |
| Germany | Praxis Reinfeld Mitte | Reinfeld | |
| Germany | Herz Kreislauf Zentrum - Klinikum Hersfeld Rotenburg GmbH | Rotenburg | |
| Germany | Studienzentrum Brinkum | Stuhr | |
| Germany | Gemeinschaftspraxis Dr. med. Josef und Dr. med. Wilma Grosskopf | Wallerfing | |
| Germany | Forschungszentrum Ruhr | Witten | |
| Germany | INFO-MED Leipzig GmbH | Zwenkau | |
| Hungary | Lausmed Kft | Baja | |
| Hungary | Tagore Medical Center | Balatonfüred | |
| Hungary | Dr Lakatos Ferenc Belgyogyaszati-Kardiologiai Maganrendelo | Békéscsaba | |
| Hungary | Clinexpert Kft. | Budapest | |
| Hungary | Del-pesti Centrumkorhaz | Budapest | |
| Hungary | High Tech Medical Kft | Budapest | |
| Hungary | MED-TIMA Kft | Budapest | |
| Hungary | Obudai Egeszsegugyi Centrum - Budapest | Budapest | |
| Hungary | Qualiclinic Kft | Budapest | |
| Hungary | Semmelweis Egyetem - Szent Rokus Klinikai Tomb | Budapest | |
| Hungary | Semmelweis Egyetem - Varosmajori Sziv es Ergyogyaszati Klinika | Budapest | |
| Hungary | Belinus Bt | Debrecen | |
| Hungary | CRU Hungary Kft. | Encs | |
| Hungary | Pharma4 Trial Kft | Gyongyos | |
| Hungary | BKS Research Kft. | Hatvan | |
| Hungary | Porcika Klinik | Hodmezovasarhely | |
| Hungary | Somogy Varmegyei Kaposi Mor Oktato Korhaz | Kaposvar | |
| Hungary | Kistarcsai Flor Ferenc Korhaz | Kistarcsa | |
| Hungary | Pest M. Flór F. Kórház V. Belgy. Oszt | Kistarcsa | |
| Hungary | IPR Hungary Kft | Miskolc | |
| Hungary | Medifarma-98 Kft | Nyiregyhaza | |
| Hungary | dr Vasas Szilard Haziorvosi Rendelo | Nyíregyháza | |
| Hungary | dr Nagy Laszlo Kardiologiai Maganrendeles es Klinikai Vizsgalohely | Orosháza | |
| Hungary | Coromed SMO Kft | Pecs | |
| Hungary | Obudai Egeszsegugyi Centrum - Zalaegerszeg | Zalaegerszeg | |
| Israel | Barzilai Medical Center | Ashkelon | |
| Israel | Bnai Zion Medical Center | Haifa | |
| Israel | Rambam Health Care Campus | Haifa | |
| Israel | The Lady Davis Carmel Medical Center | Haifa | |
| Israel | Hadassah Hebrew University Medical Center - Cardiology - The Heart Institute | Jerusalem | |
| Israel | Shaare Zedek Medical Center | Jerusalem | |
| Israel | Meir Medical Center | Kfar Saba | |
| Israel | Galilee Medical Cente | Nahariyya | |
| Israel | Rabin Medical Center, Beilinson Hospital | Petach Tikva | |
| Israel | Rabin Medical Center, Beilinson Hospital - Internal Medicine B | Petach Tikva | |
| Israel | The BARUCH PADEH Medical Center, Poriya | Poriyya | |
| Israel | Kaplan Medical Center | Re?ovot | |
| Israel | Ziv Medical Center | Safed | |
| Israel | Shamir Medical Center (Assaf Harofeh) | Zerifin | |
| Italy | Azienda Ospedaliero-Universitaria di Ferrara-Arcispedale Sant'Anna | Ferrara | |
| Italy | IRCCS Ospedale San Raffaele | Milano | |
| Italy | Azienda Ospedaliera Universitaria Federico II | Napoli | |
| Italy | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone | Palermo | |
| Italy | Fondazione IRCCS Policlinico San Matteo | Pavia | |
| Italy | Istituto Clinico Humanitas | Rozzano | |
| Italy | Azienda Ospedaliera Santa Maria di Terni | Terni | |
| Japan | Chiba University Hospital | Chiba | |
| Japan | New Tokyo Heart Clinic | Chiba | |
| Japan | Japan Community Health Care Organization Kyushu Hospital | Fukuoka | |
| Japan | Kokura Memorial Hospital | Fukuoka | |
| Japan | National Hospital Organization Takasaki General Medical Center | Gunma | |
| Japan | Hiroshima Prefectural Hospital | Hiroshima | |
| Japan | Hiroshima University Hospital | Hiroshima | |
| Japan | Hyogo Prefectural Harima-Himeji General Medical Center | Hyogo | |
| Japan | Ishikawa Prefectural Central Hospital | Ishikawa | |
| Japan | Komatsu Municipal Hospital | Ishikawa | |
| Japan | Public Central Hospital of Matto lshikawa | Ishikawa | |
| Japan | Showa University Northern Yokohama Hospital | Kanagawa | |
| Japan | Yokohama Minami Kyousai Hospital | Kanagawa | |
| Japan | Niigata University Medical & Dental Hospital | Niigata | |
| Japan | The Sakakibara Heart Institute of Okayama | Okayama | |
| Japan | National Cerebral and Cardiovascular Center Research Institute | Osaka | |
| Japan | Osaka Medical and Pharmaceutical University Hospital | Osaka | |
| Japan | Saiseikai Senri Hospital | Osaka | |
| Japan | Sakurabashi Watanabe Hospital | Osaka | |
| Japan | Nihon University Itabashi Hospital | Tokyo | |
| Japan | Tokyo Saiseikai Central Hospital | Tokyo | |
| Jordan | Abdali Hospital | Amman | |
| Jordan | Istishari Hospital | Amman | |
| Jordan | Irbid Specialty Hospital | Irbid | |
| Jordan | Pharmaceutical Research Center -Jordan University of Science & Technology/King Abdulla University Hospital - Cardiology | Irbid | |
| Latvia | Latgales Medical Center | Daugavpils | |
| Latvia | SIA ANIO | Daugavpils | |
| Latvia | D. Saulites-Kandevicas Private Practice | Liepaja | |
| Latvia | Pauls Stradins Clinical University Hospital Riga | Riga | |
| Latvia | Vidzemes Hospital | Valmiera | |
| Netherlands | Academic Medical Center - Department of Vascular Medicine | Amsterdam | |
| Netherlands | Ziekenhuis Rijnstate | Arnhem | |
| Netherlands | Rode Kruis Ziekenhuis | Beverwijk | |
| Netherlands | Reinier de Graaf Gasthuis | Delft | |
| Netherlands | HMC Westeinde | Den Haag | |
| Netherlands | Het Van Weel-Bethesda Ziekenhuis | Dirksland | |
| Netherlands | Albert Schweitzer Ziekenhuis - Location Dordrecht | Dordrecht | |
| Netherlands | Ziekenhuis Gelderse Vallei | Ede | |
| Netherlands | Maxima Medisch Centrum | Eindhoven | |
| Netherlands | Groene Hart Ziekenhuis | Gouda | |
| Netherlands | St. Jansdal Ziekenhuis | Harderwijk | |
| Netherlands | Elkerliek Ziekenhuis - Locatie Helmond | Helmond | |
| Netherlands | Treant Zorggroep | Hoogeveen | |
| Netherlands | Leids Universitair Medisch Centrum | Leiden | |
| Netherlands | Canisius-Wilhelmina Ziekenhuis (CWZ) | Nijmegen | |
| Netherlands | Stichting Radboud Universitair Medisch Centrum | Nijmegen | |
| Netherlands | Franciscus Gasthuis & Vlietland - Locatie Gasthuis | Rotterdam | |
| Netherlands | Diakonessenhuis - Locatie Utrecht | Utrecht | |
| Netherlands | VieCuri Medisch Centrum | Venlo | |
| Netherlands | Zaans Medisch Centrum | Zaandam | |
| Netherlands | Albert Schweitzer Ziekenhuis - Location Zwijndrecht | Zwijndrecht | |
| Poland | CENTRUM MEDYCZNE INTERCOR Sp. z o.o. | Bydgoszcz | |
| Poland | Centrum Medyczne Kermed - Renata Bijata-Bronisz I Ewa Kowalinska Spólka Jawna | Bydgoszcz | |
| Poland | Centrum Medyczne Pratia Bydgoszcz | Bydgoszcz | |
| Poland | DIAB Serwis Popenda Spólka Jawna | Chorzów | |
| Poland | NZOZ Twoje Zdrowie EL Sp. z o.o. | Elblag | |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska dr n. med. Adam Grzybowski | Gdansk | |
| Poland | Uniwersyteckie Centrum Kliniczne, I Klinika Kardiologii | Gdansk | |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii, lek. med. Krzysztof Cymerman | Gdynia | |
| Poland | Samodzielny Publiczny Specjalistyczny Szpital Zachodni im. Jana Pawla II | Grodzisk Mazowiecki | |
| Poland | Centrum Medyczne Pratia Katowice | Katowice | |
| Poland | SALVIA Lekston i Madej s.j. | Katowice | |
| Poland | Silmedic Sp. z o.o. | Katowice | |
| Poland | Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska | Krakow | |
| Poland | Pratia MCM Krakow | Krakow | |
| Poland | Centrum Medyczne ZDROWA | Kraków | |
| Poland | Krakowski Szpital Specjalistyczny im. Jana Pawla II - Oddzial Kliniczny Kardiologii Interwencyjnej z Pododdzialem Intenyswengo Nadzoru Kardiologicznego | Kraków | |
| Poland | Krakowskie Centrum Medyczne Sp. z o.o. | Kraków | |
| Poland | ETG Lodz - Santa Sp. z. o.o. | Lódz | |
| Poland | FutureMeds Lodz | Lódz | |
| Poland | Indywidualna Specjalistyczna Praktyka Lekarska Wlodzimierz Kus | Lódz | |
| Poland | INSTYTUT CENTRUM ZDROWIA MATKI POLKI - Klinika Kardiologii i Wad Wrodzonych Doroslych | Lódz | |
| Poland | Clinical Best Solutions - Lublin | Lublin | |
| Poland | ETG Lublin - Pro Life Medica Sp. z o.o | Lublin | |
| Poland | KO - MED Centra Kliniczne Lublin II | Lublin | |
| Poland | Szpital Sw. Anny w Miechowie | Miechów | |
| Poland | Pomorskie Centra Kardiologiczne Sp. z o.o., SKA - Mragowo | Mragowo | |
| Poland | ZOZ w Olawie, Oddzial Chorob Wewnetrznych | Olawa | |
| Poland | Futuremeds Olsztyn | Olsztyn | |
| Poland | Ostrowieckie Centrum Medyczne spólka cywilna Anna Olech-Cudzik | Ostrowiec Swietokrzyski | |
| Poland | Centrum Medyczne OMEDICA Jaroslaw Opiela i Beata Opiela s. j. | Poznan | |
| Poland | NZOZ Neuro-Kard - Ilkowski i Partnerzy Spólka Partnerska Lekarzy | Poznan | |
| Poland | Aka-Med Centrum Spólka Z Ograniczona Odpowiedzialnoscia | Ruda Slaska | |
| Poland | ETG Siedlce- Lukmed 2 Sp. z o.o. | Siedlce | |
| Poland | ETG Skierniewice - ClinMedica Research Sp. z o.o. | Skierniewice | |
| Poland | NZOZ Pro Cordis Sopockie Centrum Badan Kardiologicznych | Sopot | |
| Poland | Nowe Zdrowie-Ck Kieltucki i Wspolnicy Spolka Jawna | Staszów | |
| Poland | Osrodek Badan Klinicznych LabMed Agnieszka Karczmarczyk, Filip Karczmarczyk Spólka Cywilna | Szczecin | |
| Poland | Prywatny Gabinet Lekarski Jacek Gessek | Torun | |
| Poland | ETG Warszawa- MCM Polimedica 2 Sp. z o.o. | Warsaw | |
| Poland | Clinical Best Solutions Sp. z.o.o Spolka Komandytowa | Warszawa | |
| Poland | FutureMeds Targowek | Warszawa | |
| Poland | FutureMeds Warszawa Centrum | Warszawa | |
| Poland | Narodowy Instytut Kardiologii Stefana kardynala Wyszynskiego - Panstwowy Instytut Badawczy, Poradnia Prewencji i Leczenia Chorob Metabolicznych, Zaklad Epidemiologii, Prewencji Chorób Ukladu Krazeni | Warszawa | |
| Poland | 4 Wojskowy Szpital Kliniczny z Poliklinika Samodzielny Publiczny ZOZ we Wroclawiu | Wroclaw | |
| Poland | FutureMeds Sp. z o.o | Wroclaw | |
| Poland | Wroclawska Grupa Medyczna Pankiewicz Spolka Jawna | Wroclaw | |
| Poland | ETG Zamosc - Pro Life Medica Sp. z o.o | Zamosc | |
| Poland | KO - MED Centra Kliniczne Sp. z o.o., Osrodek Badan Klinicznych w Zamosciu | Zamosc | |
| Slovakia | Medivasa, s.r.o., Angiologicka a kardiologicka ambulancia | Žilina | |
| Slovakia | Stredoslovensky ustav srdcovych a cievnych chorob, a.s. | Banská Bystrica | |
| Slovakia | Alian, s.r.o., Kardiologicka ambulancia | Bardejov | |
| Slovakia | DIADA s.r.o. | Bardejov | |
| Slovakia | Thyreomedical s.r.o. | Bardejov | |
| Slovakia | Medispektrum s.r.o., Diabetologicka a metabolicka ambulancia | Bratislava | |
| Slovakia | Univerzitna nemocnica Bratislava | Bratislava | |
| Slovakia | Kardiologicka ambulancia NsP, n.o. | Brezno | |
| Slovakia | JM-INTERNA, s.r.o., Ambulancia vnutorneho lekarstva | Dolny Kubin | |
| Slovakia | Cardio D&R, S.R.O. Kosice | Košice | |
| Slovakia | Human-Care s.r.o | Kosice | |
| Slovakia | Medical group Kosice, s.r.o. - Kardiologicka a Interna ambulancia | Kosice | |
| Slovakia | KardioLEV s. r. o. | Levoca | |
| Slovakia | Interna a diabetologicka ambulancia - IN - DIA s.r.o., MUDr. Livia Tomasova | Lucenec | |
| Slovakia | KARDIO 1 s.r.o. | Lucenec | |
| Slovakia | Kardiomed s.r.o. | Lucenec | |
| Slovakia | Univerzitna nemocnica Martin | Martin | |
| Slovakia | Medi M and M sro | Moldava nad Bodvou | |
| Slovakia | Kardiocentrum Nitra s.r.o. | Nitra | |
| Slovakia | Medical KG, s.r.o. - Ambulancia vnutorneho lekarstva | Pieštany | |
| Slovakia | Medispol, s.r.o. | Presov | |
| Slovakia | Tatratrial s.r.o | Roznava | |
| Slovakia | Interna SK, s.r.o., Kardiologicka a interna ambulancia | Svidník | |
| Slovakia | JAL s.r.o. | Trnava | |
| South Africa | Iatros International | Bloemfontein | |
| South Africa | Tiervlei Trial Centre (TTC) | Cape Town | |
| South Africa | TREAD Research - Department of Cardiology | Cape Town | |
| South Africa | WCR - Bara Cardiology | Johannesburg | |
| South Africa | Dr JM Engelbrecht Trial Site | Somerset West | |
| South Africa | Helderberg Research Institute | Somerset West | |
| South Africa | Mediclinic Victoria | Tongaat | |
| Spain | Hospital Universitario de A Coruna | A Coruna | |
| Spain | Hospital General Universitario de Alicante Dr. Balmis | Alicante | |
| Spain | Hospital Universitario Torrecardenas | Almeria | |
| Spain | Hospital del Mar | Barcelona | |
| Spain | Hospital Universitari de Bellvitge | Barcelona | |
| Spain | Hospital Universitario Vall d'Hebron | Barcelona | |
| Spain | Hospital Universitario Reina Sofia | Córdoba | |
| Spain | Hospital Universitario Virgen de las Nieves | Granada | |
| Spain | Hospital General Universitario Gregorio Maranon | Madrid | |
| Spain | Hospital Universitario Virgen de la Victoria | Malaga | |
| Spain | Hospital Clinico Universitario de Santiago | Santiago de Compostela | |
| Spain | Hospital Universitario Virgen Macarena | Sevilla | |
| Spain | Hospital Universitario Joan XXIII de Tarragona | Tarragona | |
| Spain | Hospital Clinico Universitario de Valencia | Valencia | |
| Spain | Hospital Alvaro Cunqueiro | Vigo | |
| Spain | Hospital Universitario Miguel Servet | Zaragoza | |
| United Kingdom | Ulster Hospital | Belfast | |
| United Kingdom | Birmingham Heartlands Hospital | Birmingham | |
| United Kingdom | FutureMeds - Soho Road Health Centre | Birmingham | |
| United Kingdom | Waterloo Medical Centre | Blackpool | |
| United Kingdom | FutureMeds - Ely Bridge Surgery | Cardiff | |
| United Kingdom | University Hospital of Wales | Cardiff | |
| United Kingdom | Darlington Memorial Hospital | Durham | |
| United Kingdom | Panthera - London North | Enfield Town | |
| United Kingdom | Fowey River Practice | Fowey | |
| United Kingdom | Futuremeds - CPS Research | Glasgow | |
| United Kingdom | Panthera - Glasgow | Glasgow | |
| United Kingdom | Hounslow Medical Centre | Hounslow | |
| United Kingdom | Chelsea and Westminster Hospital | London | |
| United Kingdom | St. Bartholomew's Hospital | London | |
| United Kingdom | The Good Practice | London | |
| United Kingdom | Luton and Dunstable University Hospital | Luton | |
| United Kingdom | Atlantic Medical Group | Penzance | Cornwall |
| United Kingdom | Mounts Bay Medical | Penzance | Cornwall |
| United Kingdom | Beacon Medical Group | Plymouth | |
| United Kingdom | Craigavon Area Hospital | Portadown | |
| United Kingdom | Panthera - Preston | Preston | |
| United Kingdom | Panthera - Manchester | Rochdale | |
| United Kingdom | Queens Hospital | Romford | |
| United Kingdom | Panthera - Sheffield | Sheffield | |
| United Kingdom | Sandwell General Hospital | West Bromwich | |
| United Kingdom | FutureMeds - Bridle Road Clinic | Wirral | |
| United Kingdom | Worcestershire Royal Hospital | Worcester | |
| United States | Biofortis, Inc | Addison | Illinois |
| United States | New Mexico Clinical Research & Osteoporosis Center Inc. | Albuquerque | New Mexico |
| United States | Advanced Cardiovascular LLC | Alexander City | Alabama |
| United States | Cambridge Medical Trials | Alexandria | Louisiana |
| United States | PharmaTex Research, LLC | Amarillo | Texas |
| United States | Advanced Research Center | Anaheim | California |
| United States | Community Health Network-Anderson | Anderson | Indiana |
| United States | Northwest Heart Clinical research | Arlington Heights | Illinois |
| United States | Javara Inc - Wake Forest Health Network Family Physicians - Sunset Avenue | Asheboro | North Carolina |
| United States | Atlanta Diabetes Associates | Atlanta | Georgia |
| United States | Accelemed Research Institute | Austin | Texas |
| United States | Central Texas Clinical Research | Austin | Texas |
| United States | Northeast Cardiology Associates | Bangor | Maine |
| United States | Westside Medical Associates of Los Angeles | Beverly Hills | California |
| United States | Ascension - Cardiology Specialists of Birmingham | Birmingham | Alabama |
| United States | Cardiovascular Associates of the Southeast, LLC | Birmingham | Alabama |
| United States | Central Alabama Research | Birmingham | Alabama |
| United States | Excel Medical Clinical Trials | Boca Raton | Florida |
| United States | Advanced Heart Care, LLC | Bridgewater | New Jersey |
| United States | Chear Center LLC | Bronx | New York |
| United States | Burke Internal Medicine & Research | Burke | Virginia |
| United States | Hope Clinical Research LLC | Canoga Park | California |
| United States | East Coast Institute for Research - Canton | Canton | Georgia |
| United States | Cary Research Group, LLC | Cary | North Carolina |
| United States | Javara Inc - Tryon Medical Partners LLC | Charlotte | North Carolina |
| United States | The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute | Charlotte | North Carolina |
| United States | Chattanooga Research & Medicine, PLLC | Chattanooga | Tennessee |
| United States | Javara Inc - Healthy Steps | Chevy Chase | Maryland |
| United States | IMA Clinical Research, PC | Chicago | Illinois |
| United States | Meridian Clinical Research - Cincinnati, OH | Cincinnati | Ohio |
| United States | Meridian Clinical Research - Springfield, OH | Cincinnati | Ohio |
| United States | Clearwater Cardiovascular and Interventional Consultants | Clearwater | Florida |
| United States | Innovative Research of West Florida | Clearwater | Florida |
| United States | Alpine Research Organization, Inc. | Clinton | Utah |
| United States | Private Practice - O. Alejandro Brusco, MD FACE PA | Corpus Christi | Texas |
| United States | West Broadway Clinic | Council Bluffs | Iowa |
| United States | Cardiovascular Associates Research, LLC - Covington, LA | Covington | Louisiana |
| United States | Clinical Research Collaborative, LLC | Cumberland | Rhode Island |
| United States | Atlanta Heart Specialists | Cumming | Georgia |
| United States | Javara Inc - Bridge Creek Family Medicine | Cypress | Texas |
| United States | Southwest Family Medicine Associates | Dallas | Texas |
| United States | Texas Health Research & Education Institute | Dallas | Texas |
| United States | PriMed Clinical Research | Dayton | Ohio |
| United States | Avail Clinical Research | DeLand | Florida |
| United States | The Iowa Clinic - Cardiovascular Services | Des Moines | Iowa |
| United States | Physicians' Research Options (PRO) | Draper | Utah |
| United States | Altoona Center for Clinical Research | Duncansville | Pennsylvania |
| United States | Alta Pharmaceutical Research Center | Dunwoody | Georgia |
| United States | Cardiology Care Clinic of Lake Oconee | Eatonton | Georgia |
| United States | South Texas Research Institute | Edinburg | Texas |
| United States | David Turbay, MD, PLLC | El Paso | Texas |
| United States | Midwest Cardiovascular Research and Education Foundation | Elkhart | Indiana |
| United States | Titan Medical Research - Oceanside | Encinitas | California |
| United States | Eastern Shore Research Institute, LLC | Fairhope | Alabama |
| United States | Lillestol Research LLC | Fargo | North Dakota |
| United States | Aa Mrc, Llc | Flint | Michigan |
| United States | Invesclinic | Fort Lauderdale | Florida |
| United States | Piedmont Research Partners, LLC | Fort Mill | South Carolina |
| United States | Javara Inc - Texas Health Care Family Physicians | Fort Worth | Texas |
| United States | Valley Institute of Research - Fort Worth | Fort Worth | Texas |
| United States | Mt. Olympus Medical Research | Friendswood | Texas |
| United States | Stern Cardiovascular Foundation, Inc | Germantown | Tennessee |
| United States | Healthy Heart Cardiology | Grand Rapids | Michigan |
| United States | Prevea Health | Green Bay | Wisconsin |
| United States | Medication Management, LLC | Greensboro | North Carolina |
| United States | Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health | Greensboro | North Carolina |
| United States | Clinical Investigation Specialists | Gurnee | Illinois |
| United States | Mass General Brigham Pentucket Medical Associates - Haverhill | Haverhill | Massachusetts |
| United States | Apex Medical Research | Hazel Crest | Illinois |
| United States | New Generation of Medical Research | Hialeah | Florida |
| United States | Qway Research | Hialeah | Florida |
| United States | Abington Medical Specialists, P.C. dba AMS Cardiolog | Horsham | Pennsylvania |
| United States | Angiocardiac Care of Texas | Houston | Texas |
| United States | BioStar Clinical Research | Houston | Texas |
| United States | East Texas Cardiology, PA | Houston | Texas |
| United States | Southwest Clinical Trials | Houston | Texas |
| United States | Texas Center for Drug Development | Houston | Texas |
| United States | Texas Heart Institute | Houston | Texas |
| United States | The Heart Center Research | Huntsville | Alabama |
| United States | Hutchinson Clinic | Hutchinson | Kansas |
| United States | Medstar Health Research Institute | Hyattsville | Maryland |
| United States | Community Health Network | Indianapolis | Indiana |
| United States | East Coast Institute for Research | Jacksonville | Florida |
| United States | East Coast Institute for Research | Jacksonville | Florida |
| United States | East Coast Institute for Research - Jacksonville Monroe St | Jacksonville | Florida |
| United States | East Coast Institute for Research - Jacksonville University Blvd | Jacksonville | Florida |
| United States | East Coast Institute for Research - Perimeter Park Court | Jacksonville | Florida |
| United States | NSC Research | Johns Creek | Georgia |
| United States | NEA Baptist clinic | Jonesboro | Arkansas |
| United States | West Houston Area Clinical Trial Consultants, LLC | Katy | Texas |
| United States | Clinical Investigation Specialists | Kenosha | Wisconsin |
| United States | Holston Medical Group | Kingsport | Tennessee |
| United States | New Phase Research & Development | Knoxville | Tennessee |
| United States | East Coast Institute for Research- Lake City | Lake City | Florida |
| United States | Milton Haber, M.D | Laredo | Texas |
| United States | AB Clinical Trials | Las Vegas | Nevada |
| United States | Advanced Biomedical Research of America | Las Vegas | Nevada |
| United States | Sierra Clinical Research | Las Vegas | Nevada |
| United States | Clinical Trials of America, LLC - Lenoir, NC | Lenoir | North Carolina |
| United States | The Research Group of Lexington, LLC | Lexington | Kentucky |
| United States | Nexgen Research | Lima | Ohio |
| United States | Clinical Trials Research | Lincoln | California |
| United States | Meridian Clinical Research- Lincoln, NE | Lincoln | Nebraska |
| United States | Cardiology and Medicine Clinic | Little Rock | Arkansas |
| United States | Torrance Clinical Research Institute Inc. | Lomita | California |
| United States | American Institute of Research | Los Angeles | California |
| United States | Louisville Metabolic and Atherosclerosis Research Center (L-MARC) | Louisville | Kentucky |
| United States | Carient Heart & Vascular | Manassas | Virginia |
| United States | SV Research | Marion | Ohio |
| United States | Advanced Medical Research (AMR) | Maumee | Ohio |
| United States | ActivMed Practices and Research - Methuen | Methuen | Massachusetts |
| United States | A+ Research Inc | Miami | Florida |
| United States | Columbus Clinical Services | Miami | Florida |
| United States | Ezy Medical Research | Miami | Florida |
| United States | Finlay Medical Research Corp | Miami | Florida |
| United States | Med Research of Florida, LLC | Miami | Florida |
| United States | ProLive Medical Research | Miami | Florida |
| United States | Montana Medical Research, Inc. | Missoula | Montana |
| United States | Mobile Heart Specialists | Mobile | Alabama |
| United States | Diabetes and Endocrinology Consultants, P.C | Morehead City | North Carolina |
| United States | Burke Primary Care | Morganton | North Carolina |
| United States | McLaren Macomb Regional Medical Center | Mount Clemens | Michigan |
| United States | Inspira Medical Centers | Mullica Hill | New Jersey |
| United States | ASHA Clinical Research - Munster, LLC | Munster | Indiana |
| United States | Cardiovascular Research of Northwest Indiana, LLC | Munster | Indiana |
| United States | Syed Research Consultants | Muscle Shoals | Alabama |
| United States | New Generation of Medical Research - Naples | Naples | Florida |
| United States | BTC of New Bedford | New Bedford | Massachusetts |
| United States | Advanced Research Institute Inc | New Port Richey | Florida |
| United States | Mid-Hudson Medical Research, PLLC - New Windsor | New Windsor | New York |
| United States | IMA Clinical Research PC and Affiliates- New York, NY | New York | New York |
| United States | York Clinical Research LLC | Norfolk | Virginia |
| United States | Lynn Institute of Norman | Norman | Oklahoma |
| United States | DiGiovanna Institute for Medical Education and Research | North Massapequa | New York |
| United States | North Hills Medical Research, Inc. | North Richland Hills | Texas |
| United States | Amicis Research | Northridge | California |
| United States | Amicis Research Center-Northridge | Northridge | California |
| United States | Valley Clinical Trials, Inc | Northridge | California |
| United States | Cardiology Associates of Fairfield County | Norwalk | Connecticut |
| United States | Advocate Health and Hospitals Corporation | Oakbrook Terrace | Illinois |
| United States | Ocala Research Institute | Ocala | Florida |
| United States | Lynn Health Science Institute - East | Oklahoma City | Oklahoma |
| United States | South Carolina Clinical Research LLC | Orangeburg | South Carolina |
| United States | Ormond Beach Clinical Research LLC | Ormond Beach | Florida |
| United States | Research Integrity | Owensboro | Kentucky |
| United States | Tapia Internal Medicine Clinic | Paris | Texas |
| United States | Linq Research, LLC | Pearland | Texas |
| United States | Elite Clinical Studies | Phoenix | Arizona |
| United States | Pinehurst Medical Clinic, Inc. | Pinehurst | North Carolina |
| United States | Preferred Primary Care Physicians Group - Pleasant Hills | Pittsburgh | Pennsylvania |
| United States | Styde Research | Plano | Texas |
| United States | Cardiovascular Research of Knoxville | Powell | Tennessee |
| United States | Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc | Rapid City | South Dakota |
| United States | Dominion Medical Associates | Richmond | Virginia |
| United States | Advanced Cardiology Associates | Rochester Hills | Michigan |
| United States | Optimal Research, LLC | Rockville | Maryland |
| United States | Endocrine Research Solutions, Inc | Roswell | Georgia |
| United States | IMA Clinical Research - St. Louis, MO | Saint Louis | Missouri |
| United States | St. Louis Heart and Vascular Cardiology | Saint Louis | Missouri |
| United States | Heart and Vascular Center at Methodist Hospital | Saint Louis Park | Minnesota |
| United States | Wasatch Clinical Research | Salt Lake City | Utah |
| United States | Bandera Family HealthCare Research, LLC (BFHC) | San Antonio | Texas |
| United States | San Antonio Premier Internal Medicine | San Antonio | Texas |
| United States | Sun Research Institute | San Antonio | Texas |
| United States | Headlands Research | Sarasota | Florida |
| United States | Saratoga Clinical Research | Saratoga Springs | New York |
| United States | Javara Inc - SouthCoast Health | Savannah | Georgia |
| United States | Syed Research Consultants | Sheffield | Alabama |
| United States | Sherman Clinical Research | Sherman | Texas |
| United States | Hillcrest Clinical Research | Simpsonville | South Carolina |
| United States | Louisiana Heart Center | Slidell | Louisiana |
| United States | Frontier Clinical Research | Smithfield | Pennsylvania |
| United States | Cardio Metabolic Institute | Somerset | New Jersey |
| United States | Revival Research Institute | Southgate | Michigan |
| United States | Piedmont Healthcare - Statesville | Statesville | North Carolina |
| United States | Stephenville Medical & Surgical Clinic | Stephenville | Texas |
| United States | Clinical Research Institute of Arizona, LLC | Sun City West | Arizona |
| United States | Herman Clinical Research | Suwanee | Georgia |
| United States | MultiCare Institute for Research and Innovation- Tacoma | Tacoma | Washington |
| United States | Universal Research Group LLC | Tacoma | Washington |
| United States | BayCare Health System | Tampa | Florida |
| United States | JSV Clinical Research Study, Inc | Tampa | Florida |
| United States | Javara Inc - Highland Woods Health | The Woodlands | Texas |
| United States | Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center | Torrance | California |
| United States | Arcturus Healthcare | Troy | Michigan |
| United States | Oakland Medical Research Center | Troy | Michigan |
| United States | Eclipse Clinical Research | Tucson | Arizona |
| United States | Meridian Clinical Research- Endwell, NY | Vestal | New York |
| United States | Cardiology Partners Clinical Research Institute | Wellington | Florida |
| United States | Clinical Trials of America | West Monroe | Louisiana |
| United States | Southgate Medical Group | West Seneca | New York |
| United States | Great Lakes Medical Research, LLC | Westfield | New York |
| United States | Kansas Nephrology Research Institute | Wichita | Kansas |
| United States | West Houston Area Clinical Trial Consultants | Wichita | Kansas |
| United States | Wilmington Health Associates | Wilmington | North Carolina |
| United States | Wake Forest University Health Sciences | Winston-Salem | North Carolina |
| United States | Clinical Research of Central Florida | Winter Haven | Florida |
| United States | Penn State Health Medical Group- Berks Cardiology | Wyomissing | Pennsylvania |
| United States | Michigan Heart | Ypsilanti | Michigan |
| United States | Southern Clinical Research, LLC | Zachary | Louisiana |
| Lead Sponsor | Collaborator |
|---|---|
| NewAmsterdam Pharma | Monash University |
United States, Australia, Bulgaria, Canada, China, Croatia, Czechia, Denmark, Finland, Georgia, Germany, Hungary, Israel, Italy, Japan, Jordan, Latvia, Netherlands, Poland, Slovakia, South Africa, Spain, United Kingdom,
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|---|---|---|---|---|
| Primary | Major Adverse Cardiovascular Effect (MACE) | To evaluate the effect of obicetrapib on the risk of MACE | 30 months after last participant randomized |
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