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Immunosuppression Reduction in Failed Allograft Guided by cfDNA

Kidney Transplant; Complications Clinical Trial

Official title:
Immunosuppression Reduction in Failed Allograft Guided by cfDNA

Clinical Trial Summary

The optimal timing for immunosuppression tapering for patients with failed kidney transplant is not known. This pilot study would be to correlate rise in cf-DNA and increase in cPRA.

Clinical Trial Description

This is an observational cohort study collecting data and blood specimens at designated time points. The primary outcome will be comparing the cPRA in patients that have a rise in cf-DNA to those that do not have a rise in cf-DNA. Seondary outcomes include comparison of the combined incidence of need for transfusion, need for methylprednisolone and allograft nephrectomy, ESA dose, allograft tenderness, and gross hematuria. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04560582
Study type Observational
Source University of Minnesota
Contact Adam Bregman, MD
Phone 612-624-9444
Email renaldiv@umn.edu
Status Recruiting
Phase
Start date September 22, 2022
Completion date October 2023
View Details
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