Kidney Transplant; Complications Clinical Trial
Official title:
Implication of Serum Fluoride Level Caused by Sevoflurane Versus Isoflurane Anesthesia Upon Renal Function After Kidney Transplantation.
Our primary goal is to investigate any hidden burden upon the grafted kidney from the increase of serum fluoride resulted from sevoflurane, versus isoflurane.
Eighty patients with end stage renal failure undergoing living donor kidney transplant under
general anesthesia were included in this study, by using an open (non-blinded) study design,
patients were randomly assigned to two groups, 15 patients in each. Randomization was done
through computer generated random tables. Isoflurane group; anesthesia was maintained with
isoflurane 1-2%. Sevoflurane group; anesthesia was maintained with Sevoflurane 1-2%.
A peripheral intravenous access was secured in the hand opposite to the functioning fistula
and induction of anesthesia was done with propofol 2mg/kg, neuromuscular blockade was
maintained with atracurium 0.6mg/kg and all patients were intubated and ventilated to
maintain end-tidal carbon dioxide (ETCO2) concentration between 30-40 mmHg. Anaesthesia was
maintained with 1-2% isoflurane (isoflurane group) or 1-2% sevoflurane (sevoflurane group)
with fresh gas flow of 2 L/min. In both groups inhalational anesthetic was delivered in an
air-oxygen mixture of 1:1 ratio. Analgesia was maintained with fentanyl 1µg/kg/hr. Mannitol
and sodium bicarbonate was given immediately before reperfusion (de-clamping of renal
artery). Intraoperative monitoring included heart rate, noninvasive blood pressure, oxygen
saturation, ETCO2, ECG and central venous line was placed in the right or left internal
jugular vein depending upon the presence of dialysis catheter. Hemodynamic target include:
mean arterial pressure of > 80mmHg, CVP between 10-15 mm Hg to optimize cardiac output and
renal blood flow.
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