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De-novo Initiation of Letermovir vs Valganciclovir for Cytomegalovirus Prophylaxis in AA Kidney Trans Recip

Kidney Transplant; Complications Clinical Trial

Official title:
Historical Controlled, Single Center Open Label Pilot Comparing the Effectiveness and Tolerability of De-novo Initiation of Letermovir Versus Valganciclovir for Cytomegalovirus Prophylaxis in AA Kidney Transplant Recipients

Clinical Trial Summary

CMV viremia will be treated with either oral valganciclovir, intravenous ganciclovir or alternative agents, according to AST ID COP (American Society of Transplantation Infectious disease community of practice) guidelines.

Clinical Trial Description

Intervention: Letermovir prophylaxis. Prophylaxis is once daily dose of Letermovier starting Day 1 of post-transplant up until 6 months post-transplant. Participants enrolled in this study will also receive prophylactic acyclovir 400mg twice daily for the duration of their Letermovir treatment. Strategy for CMV Viremia: CMV viremia will be treated with either oral valganciclovir, intravenous ganciclovir or alternative agents, according to AST ID COP (American Society of Transplantation Infectious disease community of practice) guidelines. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06001320
Study type Interventional
Source Virginia Commonwealth University
Contact Idris Yakubu, PharmD
Phone 804-828-6286
Email idris.yakubu@vcuhealth.org
Status Recruiting
Phase Early Phase 1
Start date September 25, 2023
Completion date September 1, 2026
View Details
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