Clinical Trials Logo

Clinical Trial Summary

This study is to evaluate copeptin values after the subcutaneous injection of glucagon in adults (healthy volunteers and patients with diabetes insipidus or primary polydipsia). It is to investigate whether glucagon stimulates the release of copeptin as a surrogate of vasopressin.

Clinical Trial Description

The differentiation between central diabetes insipidus (cDI) and primary polydipsia (PP) is cumbersome. To date the test with the highest diagnostic accuracy is copeptin measurement after hypertonic saline Infusion. Instead of hypertonic saline Infusion, arginine infusion - known to stimulate growth hormone - is a potent stimulator of the neurohypophysis and provides a new diagnostic tool in the differential diagnosis of cDI. Copeptin measurements upon arginine stimulation discriminated patients with diabetes insipidus vs. patients with primary polydipsia with a high diagnostic accuracy of 94%. Glucagon has been shown to stimulate GH-secretion. In analogy to the known stimulatory effect of arginine Infusion it is hypothesized that glucagon might stimulate the posterior pituitary gland and could therefore be a novel diagnostic test in the polyuria-polydipsia syndrome. This study is to evaluate copeptin values after the subcutaneous injection of glucagon in adults (healthy volunteers and patients with diabetes insipidus or primary polydipsia). This study is planned as a double-blind randomized-controlled cross-over trial consisting of two parts, including healthy adults (study part 1 - proof of concept) and adults with known diagnosis of cDI or PP (study part 2 - pilot study). Study parts 1 and 2 will be conducted consecutively. If the results of study part 1 suggest that glucagon is a potent stimulator of Copeptin in healthy adults, study part 2 will be conducted. Participants will receive glucagon injection and placebo injection in random order. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04550520
Study type Interventional
Source University Hospital, Basel, Switzerland
Status Completed
Phase N/A
Start date September 28, 2020
Completion date May 30, 2021

See also
  Status Clinical Trial Phase
Completed NCT03572166 - Use of Copeptin Measurement After Arginine Infusion for the Differential Diagnosis of Diabetes Insipidus - the CARGOx Study N/A
Terminated NCT02460354 - Metformin and Congenital Nephrogenic Diabetes Insipidus Phase 1
Completed NCT02523001 - Effect of Statin Treatment on Urinary AQP2 (uAQP2/01) N/A
Active, not recruiting NCT04351945 - Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
Completed NCT00757276 - Copeptin in the Diagnosis and Differential Diagnosis of Diabetes Insipidus. The CoSIP-Study N/A
Completed NCT01940614 - Use of Copeptin in Diabetes Insipidus
Recruiting NCT02841553 - Wolfram Syndrome and WFS1-related Disorders International Registry and Clinical Study
Not yet recruiting NCT06368817 - A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma Phase 2
Completed NCT04648137 - Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls N/A
Active, not recruiting NCT00004364 - Study of Novel Types of Familial Diabetes Insipidus N/A
Completed NCT00004363 - Study of the Pathogenesis and Pathophysiology of Familial Neurohypophyseal Diabetes Insipidus N/A
Completed NCT02132676 - Shared Health Appointments and Reciprocal Enhanced Support
Completed NCT02455414 - Tracking Neurodegeneration in Early Wolfram Syndrome