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NCT04385004 Clinical Trial

Clinical, Biological and Histological Pulmonary and Renal Damage Associated With the SARS-CoV-2 Syndrome in Patients Admitted in ICU

Acute Respiratory Distress Syndrome Clinical Trial

— PR-Covid-19  

Official title:
Characterization of the Clinical, Biological and Histological Pulmonary and Renal Damage Associated With the SARS-CoV-2 Syndrome in Patients Admitted in the Intensive Care Unit

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04385004
Other study ID # 7815
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 27, 2020
Est. completion date July 2020

Study information
Verified date May 2020
Source University Hospital, Strasbourg, France
Contact Ferhat MEZIANI, MD, PhD
Phone 33 3 69 55 10 24
Email ferhat.meziani@chru-strasbourg.fr
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Renal damage in patients hospitalized for ARDS in the ICU can also be related to multiple causes including, but not limited to, the consequences of hemodynamic fluctuations in these patients or the use of nephrotoxic drugs responsible for acute post-ischemic or toxic tubular necrosis. Frequently observed abnormalities of cioagumation may also have a potential impact on renal structures, particularly glomerular capillaries.

The researchers wish to characterize and phenotype the renal impairment of patients hospitalized in intensive care with tables of severe Covid19 infections in ARDS: clinical, biological and histological (by performing post-mortem biopsies).

Translated with www.DeepL.com/Translator (free version)

Recruitment information / eligibility
Status Recruiting
Enrollment 320
Est. completion date July 2020
Est. primary completion date July 2020
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Patients over 18 years of age

- Diagnosed Covid-19 by RT PCR

- Hospitalized in intensive care for management of complications related to Covid-19 from March 1, 2020 to April 20, 2020

- Patient not having expressed his or her opposition, after information, to the re-use of his or her data for the purposes of this research.

Exclusion Criteria:

- Subject who expressed opposition to participating in the study

Study Design

Related Conditions & MeSH terms

  • Acute Lung Injury
  • Acute Respiratory Distress Syndrome
  • Respiratory Distress Syndrome, Adult
  • Respiratory Distress Syndrome, Newborn
  • Syndrome

Locations
Country Name City State
France Service Reanimation Medicale Strasbourg

Sponsors (1)
Lead Sponsor Collaborator
University Hospital, Strasbourg, France

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Analysis of Clinical, Biological and Histological Pulmonary and Renal Impairment Related to SARS-CoV-2 1 month
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