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Clinical Trial Summary

Single-arm, open-label, phase II trial in 200 competent adult male patients with Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-3 and progressive metastatic prostate cancer, failing, failed, refused, not eligible for or no access to further approved lines of therapy. Patients will undergo sequential FDG positron emission tomography (PET) and 18F-DCFPyL PET to assess FDG/DCFPyL concordance fraction. Patients with DCFPyL/FDG concordance of 50% or greater will be treated with 131I-PSMA-1095 radioligand therapy (RLT). Best post-treatment serum prostate specific antigen response will be compared to concordance fraction.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04085991
Study type Interventional
Source Sir Mortimer B. Davis - Jewish General Hospital
Contact
Status Terminated
Phase Phase 2
Start date July 31, 2020
Completion date January 15, 2023

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