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Clinical Trial Summary

This study evaluates the efficacy and safety of ethosuximide in the treatment of refractory depressive disorder in adults. Half of participants will receive ethosuximide and escitalopram in combination, while the other half will receive a placebo and escitalopram.


Clinical Trial Description

Ethosuximide is a inhibitor of low-voltage-sensitive T-type calcium channels(T-VSCCs). It has higher selectivity to T-VSCCs and can enter cerebrospinal fluid through the blood-brain barrier, inhibit T-VSCCs on the lateral habenular nucleus neurons, and then inhibit the cluster discharge of neurons, resulting in a rapid antidepressant effect. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03887624
Study type Interventional
Source Zhejiang University
Contact
Status Terminated
Phase Early Phase 1
Start date May 21, 2019
Completion date April 1, 2021

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