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Investigate the Clinical Responses of Ethosuximide in Patients With Treatment-Resistant Depression.

Depressive Disorder, Treatment-Resistant Clinical Trial

Official title:
A Randomized, Parallel-group，Placebo-controlled, Double-blind Clinical Trial to Evaluate the Efficacy and Safety of Ethosuximide in Chinese Patients With Treatment-Resistant Depression.

Clinical Trial Summary

This study evaluates the efficacy and safety of ethosuximide in the treatment of refractory depressive disorder in adults. Half of participants will receive ethosuximide and escitalopram in combination, while the other half will receive a placebo and escitalopram.

Clinical Trial Description

Ethosuximide is a inhibitor of low-voltage-sensitive T-type calcium channels(T-VSCCs). It has higher selectivity to T-VSCCs and can enter cerebrospinal fluid through the blood-brain barrier, inhibit T-VSCCs on the lateral habenular nucleus neurons, and then inhibit the cluster discharge of neurons, resulting in a rapid antidepressant effect. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03887624
Study type Interventional
Source Zhejiang University
Contact
Status Terminated
Phase Early Phase 1
Start date May 21, 2019
Completion date April 1, 2021
View Details
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