Clinical Trial Details
— Status: Not yet recruiting
Administrative data
| NCT number |
NCT03505073 |
| Other study ID # |
10256 |
| Secondary ID |
|
| Status |
Not yet recruiting |
| Phase |
|
| First received |
|
| Last updated |
|
| Start date |
May 2020 |
| Est. completion date |
December 31, 2020 |
Study information
| Verified date |
March 2020 |
| Source |
Assiut University |
| Contact |
n/a |
| Is FDA regulated |
No |
| Health authority |
|
| Study type |
Observational [Patient Registry]
|
Clinical Trial Summary
Studying and investigating the association between dietary habits and risk factors for
atherosclerotic cardiovascular diseases in Assiut governorate
Description:
Atherosclerotic cardiovascular diseases (ASCVD) has become the largest single cause of death
worldwide. It is responsible for an estimated 17 million deaths and led to 151 million
disability-adjusted life years (DALYs) lost (~30.0% of all deaths and 14.0% of all DALYs
lost).1 Further, by 2020, 32.0% of the world population deaths will be caused by ASCVD and by
2030; it's expected to be responsible for 33.0% of all deaths (24.2 million).2 Most of
atherosclerotic cardiovascular disease events nowadays are taking place in low- and
middle-income countries with 80% of the burden occurring in these countries.3
In Egypt, since 1990, ASCVD related mortality was increased over three folds; to be
responsible for over 40% of deaths compared with 12% reported two decades earlier.4 Egypt was
categorized as a "very-high-risk country for ASCVD" (according to 2016 ESC Guidelines on
cardiovascular disease prevention in clinical practice).5 According to (WHO 2014), ASCVD
related mortality in Egypt has been increased to account for 46% of total deaths.
Multiple risk factors are attributed to causing ASCVD. These risk factors fall into the
categories of either nonmodifiable or modifiable risk factors.6 Nonmodifiable risk factors
consist of those conditions that a person cannot alter, including age, heredity, ethnicity
and type 1 diabetes.
Whereas modifiable risk factors are conditions that can be altered by making certain
lifestyle changes.
In 2003, the Canadian Heart and Stroke Foundation identified nine major modifiable risk
factors for ASCVD, namely, tobacco smoking, alcohol abuse, physical inactivity, unhealthy
dietary habits, obesity, high BP, high concentrations of dietary fat and blood lipids, and
high blood glucose concentrations.7 Sudden stress, frequent migraine and the use of oral
contraceptives have also been identified as risk factors for the increased incidence of
coronary disease and stroke.8,9 The Egyptian National Hypertension Project (NHP)10,11 was
conducted between year 1991 and 1993 in six Egyptian governorates to define the prevalence of
ASCVD risk factors in adult Egyptians. The project documented an extremely high prevalence
and prominent clustering of ASCVD risk factors in adult men and women particularly obesity.
Since that time, and despite the increasing ASCVD related morbidity and mortality in our
Egyptian society, as mentioned before, there's no recent studies (up to our knowledge) was
conducted to determine the risk factors associated to ASCVD.
This study overall aim is to systematically explore and investigate the association between
dietary habits and risk factors for atherosclerotic cardiovascular diseases in Assiut
governorate.
