Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation

Posterior Circulation Brain Infarction Clinical Trial

— CANVAS-II  

Official title:

Choice of Anesthesia for Endovascular Treatment of Acute Ischemic Stroke in Posterior Circulation: a Randomized Controlled Exploratory Study (CANVAS-Ⅱ)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03317535
• Other study ID #: 2017-10-15
• Status: Completed
• Phase: N/A
• Start date: March 18, 2018
• Est. completion date: June 23, 2021

Study information

• Verified date: May 2023
• Source: Beijing Tiantan Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

There is few randomized controlled clinical to investigated the impact of anesthetic type on outcome in patients with acute ischemic stroke in posterior cerebral circulation. It is unknown whether the choice of anesthesia is impacted on the outcomes for these patients or not. The investigators will perform a randomized controlled pilot clinical trial of general anesthesia versus local anesthesia/conscious sedation to explore and find out a potential fact whether anesthetic type alters perioperative neurological function in patients with acute ischemic stroke in posterior cerebral circulation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 93
• Est. completion date: June 23, 2021
• Est. primary completion date: June 23, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• Patients with acute ischemic stroke in posterior cerebral circulation scheduled to receive emergency endovascular treatment; Age > 18; The onset time is within 24 hours; Modified rankin score =2 before onset.

Exclusion Criteria:

• Radiological ambiguity concerning infarction and vessel occlusion; Additional intracerebral hemorrhage; Anterior circulation infraction; Coma on admission (Glasgow coma score less than 8); NIHSS less than 6 or more than 30; Severe agitation or seizures on admission; Obvious loss of airway protective reflexes and/or vomiting on admission; Being intubated before treatment on admission; Known allergy to anesthetic or analgesic;

Related Conditions & MeSH terms

• Brain Infarction
• Infarction
• Ischemic Stroke
• Posterior Circulation Brain Infarction

Intervention

Procedure:
• General anesthesia
Patients will be injected with propofol, remifentanil and muscular relaxant with controlled ventilation.
• Local anesthesia/concious sedation
Patients will be injected with propofol and remifentanil.
• Spontaneous breath
Patients will be kept spontaneous breath.
• Controlled ventilation
Patient will be kept with controlled ventilation.

Locations

Country	Name	City	State
China	Ruquan Han	Fengtai	Beijing
China	Fan Wang	Guiyang	Guizhou

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Tiantan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	modified rankin score(mRS)	Modified rankin score(mRS)is used to evaluate the primary outcome. The scale of mRS is 0 to 6. The best neurological outcome is the mRS with 0, indicating no any symptom left, and a good neurological outcome is agreed with a mRS=2. mRS of 6 is the worst, indicating death. mRS will be evaluated by outcomes assessor who is blinded to the grouping.	post-procedural 90 days