Obesity Clinical Trial
Official title:
Unsaturated Fatty Acids Enriched-diet to Improve Cardiorespiratory Fitness, Metabolic Flexibility and Glucose Tolerance in Obese Patients: a Feasibility Study
The investigators hypothesize that a dietary intervention aimed at increasing unsaturated fatty acids (UFA) consumption is feasible and has the potential to improve cardiorespiratory fitness, metabolic flexibility and glucose tolerance in symptomatic obese heart failure with preserved ejection fraction (HFpEF) patients.
Twelve obese HFpEF subjects with exercise intolerance (reduce cardiorespiratory fitness
measured at maximal cardiopulmonary exercise test [CPX]) will be assigned to a single-arm
open-label dietary intervention in which subjects are encouraged and financially supported to
increase daily UFA consumption. The investigators will measure dietary compliance with a
validated 24-hour dietary recall and with objective operator-independent biomarkers of UFA
consumption.
The investigators will also measure the effects of UFA supplementation on: metabolic
flexibility, glucose tolerance and body composition. Participants will have the option to
participate in overnight session in the whole indirect calorimeter room (WIC) at baseline and
at the end of the study.
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