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Immediate Release Versus Slow Release Carvedilol in Heart Failure — SLOW-HF  

Heart Failure With Reduced Ejection Fraction Clinical Trial

Official title:
Assessment of Clinical Effect and Treatment Quality of Rapid Release Carvedilol Versus SLOW Release Carvedilol-SR in HEART FAILURE Patient (SLOW-HF): A Prospective Randomized, Open-label, Multicenter Study

Clinical Trial Summary

Assessment of clinical effect and treatment quality of immediate release carvedilol (IR) versus slow release carvedilol (SR) in patients with HFrEF

Clinical Trial Description

The SLOW-HF trial is a phase 4, randomized, open label, multicenter study to evaluate the therapeutic efficacy of carvedilol-SR compared to carvedilol-IR in patients with heart failure with reduced ejection fraction. Patients with stable HFrEF will be randomly assigned (1:1) to carvedilol SR group (160 patients) and carvedilol IR group (160 patients).

After randomization, patients will be followed for 6 months. The primary endpoint is the change in NT-proBNP level from baseline to the study end. The secondary endpoints include the frequency of NT-proBNP increment >10% from baseline, composite of all-cause mortality and readmission, mortality rate, readmission rate, changes in blood pressure, quality of life, and drug compliance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03209180
Study type Interventional
Source Seoul National University Bundang Hospital
Contact
Status Recruiting
Phase Phase 4
Start date October 27, 2016
Completion date December 31, 2018
View Details
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