Chronic Stable Coronary Artery Disease Clinical Trial
1.1 To build a TCM diagnosis and treatment database for chronic stable CAD; 1.2 To summarize
the pattern of TCM medicine used and the effect of the medication in chronic stable CAD.
1.3 To formulate a syndrome differentiation determined medicine plan based on the
improvement in the quality of life on chronic stable CAD patients.
| Status | Recruiting |
| Enrollment | 2000 |
| Est. completion date | December 2017 |
| Est. primary completion date | December 2017 |
| Accepts healthy volunteers | Accepts Healthy Volunteers |
| Gender | All |
| Age group | N/A and older |
| Eligibility |
Inclusion Criteria: - without age limit - diagnose as chronic SCAD at first visit - heart function classification between II~III Canada classification(CCS) - Be willing to accept Chinese herbal decoction - sign an informed consent Exclusion Criteria: - suffer from acute myocardial infarction (AMI) ,unstable angina or prior revascularization(i.e PCI,CABG) in the latest 60 days . - have such diseases as follow: a.poorly controlled blood pressure even taken medicine(systolic pressure=180mmHg, diastolic pressure=100mmHg); - severe arrhythmia(atrial fibrillation with rapid ventricular response, atrial flutter, paroxysmal ventricular tachycardia, etc); c.pulmonary heart disease, rheumatic heart disease, myocarditis, cardiomyopathy, aortic dissection, pulmonary embolism. - hyperthyreosis, cervical spondylosis, gallbladder-cardiac syndrome, gastroesophageal reflux, esophageal hiatal hernia, neurosis, climacteric syndrome and other diseases which would cause chest pain. - alanine transaminase(ALT) or serum creatinine(Scr) more than twice the normal reference value. - hemoglobin(Hb)<100g/L or have severe hematological system disease. - malignant tumor. - pregnant, lactating women or other women have reproductive requirement. - psychosis or cognition impairment person. - taken chinese medicine decoction in recent two weeks. - not take part in any other clinical trail. |
| Country | Name | City | State |
|---|---|---|---|
| China | The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine | Anhui | |
| China | Beijing Hospital of Traditional Chinese Medicine | Beijing | |
| China | Dongfang Hospital of Beijing University of Chinese Medicine | Beijing | |
| China | Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine | Beijing | |
| China | Guang'anmen Hospital of China Academy of Chinese Medical Sciences | Beijing | |
| China | the third Affiliated to Beijing University of Chinese Medicine | Beijing | |
| China | Xiyuan Hospital of China Academy of Chinese Medical Sciences | Beijing | |
| China | Affiliated Hospital of Changchun University of Traditional Chinese Medicine | Changchun | |
| China | Affiliated Hospital of Gansu University of Chinese Medicine | Gansu | |
| China | Guangdong Provincial Hospital of Chinese Medicine | Guangdong | |
| China | Guangdong Second Troditional Chinese Medicine Hospital | Guangdong | |
| China | First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine | Guangzhou | |
| China | Heilongjiang Provincial Hospital of traditional Chinese Medicine | Heilongjiang | |
| China | Henan Province Hospital of TCM | Henan | |
| China | The First Affiliated Hospital of Henan University of TCM | Henan | |
| China | Affiliated Hospital of Hunan Academy of Chinese Medicine | Hunan | |
| China | The First Hospital of Hunan University of Chinese Medicine | Hunan | |
| China | The Second Affiliated Traditional hospital of Hunan University of Traditional Chinese Medicine | Hunan | |
| China | Jiangsu Province Hospital of TCM | Jiangsu | |
| China | Jiangxi Provincial Hospital of Chinese Medicine | Jiangxi | |
| China | Affiliated Hospital of Liaoning University of Traditional Chinese Medicine | Liaoning | |
| China | The Second Affiliated Hospital of Liaoning University of traditional Chinese Medicine | Liaoning | |
| China | Shandong Province Hospital of Traditional Chinese Medicine | Shandong | |
| China | Shanxi Hospital of Traditional Chinese Medicine | Shanxi | |
| China | Shanxi Province Hospital of Traditional Chinese Medicine | Shanxi | |
| China | The Affiliated Hospital to Shanxi University of Traditional Chinese Medicine | Shanxi | |
| China | The Second Affiliated Hospital of Shanxi University of Traditional Chinese Medcine | Shanxi | |
| China | Shijiazhuang Traditional Chinese Medicine Hospita | Shijiazhuang | |
| China | First Teaching Hospital of Tianjin University of TCM | Tianjin | |
| China | Second Affiliated Hospital of Tianjin University of TCM | Tianjin | |
| China | Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital | Tianjin | |
| China | Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region | Xinjiang |
| Lead Sponsor | Collaborator |
|---|---|
| First Teaching Hospital of Tianjin University of Traditional Chinese Medicine |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | EuroQol-5 Dimensions (EQ-5D) | change from take chinese herb in one week | ||
| Primary | Four diagnostic method of TCM | change from take chinese herb in one week | ||
| Primary | electrocardiograms(ECG) | change from take chinese herb in one week | ||
| Primary | dynamic electrocardiogram | change from take chinese herb in one week | ||
| Primary | ultrasonic cardiogram | change from take chinese herb in one week | ||
| Primary | treadmill exercise testing (TET) | change from take chinese herb in one week |