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Clinical Trial Summary

Stereotactic radiosurgery (SRS) is increasingly administered as the sole treatment of brain metastases, in order to spare acute and long term side effects associated with whole brain radiotherapy. Local control of SRS treated lesions is good, but patients tend to develop additional brain metastases subsequently. Nivolumab is a modulator of the immune system. Treatment with Nivolumab is associated with an increase in local control and survival in patients with non-small cell lung cancer and clear cell renal cell carcinoma. In the presence of Nivolumab, treatment of brain metastases with SRS may trigger an immune reaction against cancer. Therefore, the combination of SRS with Nivolumab may reduce the development of new brain metastases and improve patient survival. The purpose of this study is to assess the effect of combining Nivolumab and SRS in controlling cancer progression. SRS will be administered to patients while they are receiving Nivolumab.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02978404
Study type Interventional
Source Centre hospitalier de l'Université de Montréal (CHUM)
Contact
Status Active, not recruiting
Phase Phase 2
Start date June 2, 2017
Completion date December 31, 2023

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