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A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy — TdVax  

Melanoma Clinical Trial

Official title:
A Feasibility Study Utilizing Immune Recall to Increase Response to Checkpoint Therapy

Clinical Trial Summary

The purpose of this study is to determine the safety and feasibility of administering the Tetanus Diptheria Vaccine (Td) or Polio Boost Immunization (IPOL) to patients with metastatic melanoma who are receiving immune checkpoint inhibitor (IO) therapy per standard of care. Subjects will have the vaccine at cycle 4 of IO therapy and will have research blood and tissue samples collected prior to starting IO therapy, at cycle 4 prior to vaccine administration, and at 12-17 days post vaccine.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05077137
Study type Interventional
Source Duke University
Contact Carol Ann Wiggs, BSN
Phone 919-684-0281
Email carolann.wiggs@duke.edu
Status Recruiting
Phase Phase 1
Start date September 7, 2021
Completion date September 1, 2024
View Details
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