Clinical Trials Logo
  1. Home
  2. Other
  3. NCT02264626

Sedation During Noninvasive Ventilation (NIV) — REMI  

Acute Hypercapnic Respiratory Failure Clinical Trial

Official title:
Effects of Remifentanil Based Sedation on Patient-ventilator Interaction, in Patients Undergoing Noninvasive Ventilation (NIV)

Clinical Trial Summary

In patients undergoing NIV for acute respiratory, lack of tolerance is one of the main reason of failure.

This may result in a poor synchrony between the patient and the machine, leading to gross mismatching and potentially to an increased work of breathing.

The investigators aim to investigate whether in these patients poorly responding to NIV the use of a sedation protocol using remifentanil will lead to an improve patient-ventilator interaction and better compliance to NIV.

Clinical Trial Description

In patients undergoing NIV for acute respiratory, lack of tolerance is one of the main reason of failure.

This may result in a poor synchrony between the patient and the machine, leading to gross mismatching and potentially to an increased work of breathing.

The investigators aim to investigate whether in these patients poorly responding to NIV the use of a sedation protocol using remifentanil will lead to an improve patient-ventilator interaction and better compliance to NIV.

In this physiological study the investigators will study 15 patients at risk of failing NIV because of scarce tolerance and showing clinical signs of poor interaction with the ventilator.

Once the patient will be enrolled the investigators will record using the balloon-catheter technique the online measurement of respiratory mechanics, to assess the inspiratory muscle effort and the matching between the patient breathing pattern and that of the ventilator The investigators will also record the clinical success of sedation (i.e. need or not for endotracheal intubation) ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02264626
Study type Interventional
Source Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi
Contact stefano nava, md
Phone 393333751828
Status Recruiting
Phase N/A
Start date October 2014
Completion date October 2017
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT06007495 - Pilot Physiological Evaluation of an Investigational Mask With Expiratory Washout. N/A
Recruiting NCT02111876 - Systematic Follow-up of Patients Surviving an Episode of Acute Hypercapnic Respiratory Failure in the ICU N/A
Recruiting NCT03033251 - High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease N/A
Not yet recruiting NCT05011877 - The Simplify Project
Terminated NCT00213395 - Clinical Efficacy of a Cephalic Mask for Noninvasive Ventilation During Acute Hypercapnic Respiratory Failure N/A
Not yet recruiting NCT05499039 - High Flow Nasal Cannula Versus Non-Invasive (NIV)in Both Hypoxemic and Hypercapnic Respiratory Failure. N/A
Completed NCT04102735 - Under the Nose Face Mask to Prevent Facial Pressure Ulcers During NIV for Acute Hypercapnic Respiratory Failure (AHRF) N/A
Not yet recruiting NCT06064409 - Optimal Timing and Failure Prediction of High Flow Nasal Cannula Oxygen Therapy in Emergency Department: Prospective Observational Single Center Study
Terminated NCT04650412 - Integrated Care of Co-morbidities vs Standard Care After AHRF in the Intensive Care Unit N/A
Active, not recruiting NCT06374589 - Closed-Loop O2 Use During High Flow Oxygen Treatment Of Critical Care Adult Patients (CLOUDHFOT) N/A
Recruiting NCT04640948 - High VS Low Flow Nasal O2 for Acute Hypercapnic Respiratory Failure N/A
Completed NCT02538263 - Volume-targeted Versus Pressure-limited Noninvasive Ventilation in Patients With Acute Hypercapnic Respiratory Failure N/A
Recruiting NCT06204276 - Asymmetrical Versus Conventional High-flow Nasal Cannula in Acute Respiratory Failure N/A
Not yet recruiting NCT03756415 - CO2 Clearance During Noninvasive Ventilation (NIV) N/A
Recruiting NCT06108284 - Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure N/A
Not yet recruiting NCT05674760 - ReAcT CO2: A Study to Assess TcCO2 to Guide Acute NIV N/A
Recruiting NCT05513508 - The ROTAtional-USE of Interface STUDY N/A
Recruiting NCT03642002 - The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU N/A
Not yet recruiting NCT04362787 - High Pressure Non Invasive Ventilation in Hypercapnic Respiratory Failure
Completed NCT04109560 - HFNC and Acute Hypercapnic Respiratory Failure