Atherosclerotic Cardiovascular Disease Clinical Trial
Official title:
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Effect of Alirocumab (SAR236553/REGN727) on the Occurrence of Cardiovascular Events in Patients Who Have Recently Experienced an Acute Coronary Syndrome
Primary Objective:
To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV)
events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial
infarction (MI), fatal and non-fatal ischemic stroke, unstable angina (UA) requiring
hospitalization) in participants who experienced an acute coronary syndrome (ACS) event 4 to
52 weeks prior to randomization and were treated with evidence-based medical and dietary
management of dyslipidemia.
Secondary Objectives:
- To evaluate the effect of alirocumab on secondary endpoints (any CHD event , major CHD
event, any CV event, composite of all cause mortality/non-fatal MI/non-fatal ischemic
stroke, CHD deaths, CV deaths, all cause mortality).
- To evaluate the safety and tolerability of alirocumab.
- To evaluate the effect of alirocumab on lipid parameters.
18924 number of participants aged >= 40 years old were randomized in the study. ;
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