Patients Undergoing Coronary Angiography Clinical Trial
Official title:
The Role of Newer and Traditional Risk Factors in the Development, Extent and Manifestation of Coronary Artery Disease
| NCT number | NCT01585948 |
| Other study ID # | UOICAD2010 |
| Secondary ID | |
| Status | Completed |
| Phase | |
| First received | |
| Last updated | |
| Start date | November 2009 |
| Est. completion date | March 2020 |
| Verified date | March 2020 |
| Source | University of Ioannina |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | |
| Study type | Observational |
In the present study the investigators will measure the extent of coronary artery disease via coronary angiography and the correlating risk factors.
| Status | Completed |
| Enrollment | 1104 |
| Est. completion date | March 2020 |
| Est. primary completion date | May 2013 |
| Accepts healthy volunteers | No |
| Gender | All |
| Age group | 18 Years to 90 Years |
| Eligibility |
Inclusion Criteria: - Any subject eligible for coronary angiography with or without known CV disease for clinical reasons. Exclusion Criteria: - Patients revascularized in the past, with either coronary artery bypass grafting or percutaneous coronary intervention, will be excluded from the study since it is not possible to describe the extent of CAD in these patients. - Moderate or severe aortic stenosis. |
| Country | Name | City | State |
|---|---|---|---|
| Greece | 2nd Department of Cardiology, University Hospital of Ioannina | Ioannina |
| Lead Sponsor | Collaborator |
|---|---|
| University of Ioannina | Catheterization Laboratory of 1st IKA Hospital, Athens, University Hospital, Ioannina |
Greece,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | The incidence and extent of coronary artery disease between diabetics and non-diabetic patients. | We will investigate the incidence, extent and clinical manifestation of coronary artery disease in diabetics and non-diabetics undergoing coronary angiography for clinical reasons. | Up to four years on average. | |
| Secondary | The incidence and extent of coronary artery disease via coronary angiography scores and related biochemical and demographical risk factors. | To associate the incidence, extent and clinical manifestation of coronary artery disease with classic demographic risk factors (such as smoking, alcohol consumption, physical exercise, arterial hypertension, family history of diabetes mellitus or coronary artery disease) and common biochemical risk factors (such as fasting glucose levels, urea, creatinine, HbA1c%, uric acid, total cholesterol, HDL, LDL, triglycerides, VLDL, glomerular filtration rate - GFR). | Up to 4 years on average. | |
| Secondary | The incidence, extent and clinical manifestation of coronary artery disease and the circulating levels of hs-CRP, adipokines and RAGEs. | To associate the incidence, extent and clinical manifestation of coronary artery disease with systemic inflammatory status assessed by hs-CRP levels, circulating adipokines (adiponectin, resistin) and the receptors of advanced glycation end products (sRAGE and esRAGE). | Up to 4 years on average. | |
| Secondary | TCF7L2 gene polymorphims and the incidence and extent of coronary artery disease. | To associate the incidence, extent and clinical manifestation of coronary artery disease with the rs7903146 single nucleotide polymorphism of TCF7L2 gene, that has been strongly associated with diabetes mellitus development. | Within a maximum period of 4 years. |