Chronic Major Depressive Disorder Clinical Trial
Official title:
Schema-Focused Therapy for Chronic Depression: Efficacy and Mechanisms of Change
Schema focused therapy (SFT) is an innovative treatment approach to chronic, lifelong problems that incorporates cognitive, behavioral, experiential and psychodynamic elements and techniques. This study will determine whether SFT is a suitable and effective treatment for chronic depression in terms of acute effects and the prevention of relapse/recurrence. The secondary aim of this study is to identify the underlying mechanisms of change in SFT that lead to recovery from depression and the prevention of future relapse/recurrence.
Status | Completed |
Enrollment | 25 |
Est. completion date | January 2016 |
Est. primary completion date | January 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Chronic MDD as defined by the DSM-IV (meeting full criteria of MDD for at least 2 years). - Beck Depression Inventory II (BDI-II) score at screening >=20 (moderate to severe depression) - Can understand and speak the Dutch language - Has internet access at home Exclusion Criteria: - Acute suicide risk - Substance induced mood disorder - Medical condition causes depression directly or through medication intake - MDD with psychotic features - DSM-IV Bipolar disorder (current or past) - DSM-IV Psychotic disorder (current or past) - DSM-IV alcohol or drug dependence - Autism Spectrum Disorders (Autistic Disorder, Asperger Syndrome, Pervasive developmental disorder NOS, Rett syndrome, Childhood disintegrative disorder) - Cluster A and Cluster B personality disorders - Started with antidepressant medication within three months prior to initial screening. Patients who receive antidepressant medication for more than 3 months prior to the start of the study can keep taking their medication and will not be excluded from participation. - MRI contra-indications, such as claustrophobia, metal parts in the body and, for women, current pregnancy or breastfeeding. |
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Netherlands | Academic Community Mental Health Center, Riagg | Maastricht | Limburg |
Lead Sponsor | Collaborator |
---|---|
Maastricht University Medical Center | Academic Community Mental Health Center, Riagg |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Depressive symptom improvement | Weekly during baseline and intervention; Monthly during follow-up | No | |
Secondary | Depressive relapse/recurrence | Measured at 12 month follow-up | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00970437 -
A Comparison of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and System of Supportive Psychotherapy (SYSP) for Early Onset Chronic Depression
|
N/A |