First Time in Human Study

Depressive Disorder and Anxiety Disorders Clinical Trial

— FTIM  

Official title:

A First Time in Human Study to Assess the Safety, Tolerability and Pharmacokinetics of GSK356278 (PDE4 Inhibitor) in Healthy Volunteers

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01031186
• Other study ID #: 113324
• Status: Completed
• Phase: Phase 1
• First received: November 5, 2009
• Last updated: July 25, 2017
• Start date: November 23, 2009
• Est. completion date: April 7, 2010

Study information

• Verified date: July 2017
• Source: GlaxoSmithKline
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study will evaluate the safety, tolerability, and pharmacokinetics of GSK356278 in male volunteers

Description:

To evaluate the safety, tolerability and pharmacokinetics of single ascending doses of GSK356278 and may assess the effect of food on GSK356278 pharmacokinetics. They study will assess the compound's effect on nausea, emesis and alertness. Close monitoring of cardiovascular parameters will be included.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: April 7, 2010
• Est. primary completion date: April 7, 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• AST, ALT, alkaline phosphate and bilirubin less than or equal to 1.5 times upper limit of normal.

• Healthy as determined by a responsible and experienced physician based on a medical evaluation including medical history, physical examination, laboratory tests and cardiac monitoring.

• Males aged between 18 and 65 years inclusive at the time of signing the informed consent.

• Males must agree to appropriate forms of contraception from administration of first dose through to 3 months after taking the final dose.

• Body weight greater than or equal to 50 kg and BMI within the range of 18-29.9 m2 (inclusive)

• Capable of giving written informed consent.

• QTcB or QTcF less than 450 msec

Exclusion Criteria:

• A positive pre-study Hep B or positive Hep C result within 3 months of screening.

• Current or chronic history of liver disease or known hepatic or biliary abnormalities

• A positive pre-study alcohol and drug screen

• A positive test for HIV antibody.

• History of regular alcohol consumption within 6 months of the study defined as an average weekly intake of greater than 21 units or average daily intake of greater than 3 units

• The subject has participated in a clinical trial and has received investigational product within the time period of 30 days prior to first dosing day (or 5 half-lives or twice the duration of the biological effect of the drug, whichever is longer)

• Exposure to more than 4 new chemical entities in the last 12 months prior to the first dosing day

• Use of prescription or non-prescription drugs including vitamins, herbal and dietary supplements within 7 days (or 14 days if the drug is a potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first dose unless in the opinion of the investigator and medical monitor the medication will not interfere with the study procedures or compromise subject safety.

• History of sensitivity to any of the study medication or history of drug or other allergy that in the opinion of the investigator or medical monitor contraindicates their participation.

• Where participation in the study would result in donation of blood or blood products in excess of 500 ml within a 56 day period.

• Unwillingness or inability to follow the procedures in the protocol.

• Subject is mentally or legally incapacitated.

• Subjects who have asthma or a history of asthma.

• Urinary cotinine levels indicative of smoking or history of regular use of tobacco or nicotine containing products within 6 months prior to screening.

• Consumption of red wine, seville oranges, grapefruit or grapefruit juice and/or pummelos, exotic citrus fruits, grapefruit hybrids or fruit juices from 7 days prior to the first dose.

• History of any significant psychiatric illness.

• Any history of suicidal behaviour or any suicidal ideation of type 4 or 5 on the Columbia Suicide Severity Rating Scale in the last 6 months.

• History of presence of clinically significant cardiac arrhythmias or other clinically significant cardiac disease.

Related Conditions & MeSH terms

• Anxiety Disorders
• Depression
• Depressive Disorder
• Depressive Disorder and Anxiety Disorders

Intervention

Drug:
• GSK356278
GSK356278
• PLACEBO
PLACEBO

Locations

Country	Name	City	State
Australia	GSK Investigational Site	Randwick	New South Wales

Sponsors (1)

Lead Sponsor	Collaborator
GlaxoSmithKline

Country where clinical trial is conducted

Australia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To assess safety and tolerability of single escalating oral doses of GSK356278 in healthy male volunteers		72 hours
Secondary	To investigate the pharmacokinetics of single escalating doses of GSK356278 in healthy male volunteers		72 hours

External Links

•   Researchers can use this site to request access to anonymised patient level data and/or supporting documents from clinical studies to conduct further research.
•   Results for study 113324 can be found on the GSK Clinical Study Register.