Chronic Major Depressive Disorder Clinical Trial
Official title:
A Comparison of Cognitive Behavioral Analysis System of Psychotherapy (CBASP) and System of Supportive Psychotherapy (SYSP) for Early Onset Chronic Depression
The purpose of this study is to compare the efficacy of the Cognitive Behavioural Analysis System of Psychotherapy (CBASP) with the non-specific System of Supportive Psychotherapy (SYSP)in early onset chronically depressives.
Effective treatment strategies for chronic depression are urgently needed since it is not
only a common and particularly disabling disorder, but is also considered treatment resistant
by most clinicians. There are only a few studies on chronic depression indicating that
traditional interventions are not as effective as in acute, episodic depression. In addition,
most of the studies had methodological weaknesses, such as the very short courses of
psychotherapy. Usually, chronic depression begins early in life, is often associated with
early interpersonal trauma, and results in an even more substantial human capital loss than
the late-onset group. Furthermore, it shows a weak response to medication and a high rate of
relapse after an initial response. With the present multicentre study, the efficacy of the
only specific psychotherapy for chronic depression (Cognitive Behavioural Analysis System of
Psychotherapy/CBASP) is compared with a non-specific System of Supportive Psychotherapy/SYSP
in early onset chronically depressives. CBASP faired very well in one large trial but has
never been directly compared to a non-specific psychotherapeutic control. Another innovative
aspect of the study is the use of an extended course of psychotherapy (32 sessions). Primary
hypothesis: CBASP is more effective in reducing depressive symptoms than SYSP.
A naturalistic study following up the patients of the trial up to two years after termination
of the study treatments is performed in order to investigate the long-term effectiveness of
CBASP compared to the System of Supportive Psychotherapy. The primary outcome of this
follow-up study is the rate of well-weeks (weeks with no or minimal depression symptoms)
during the two years after termination of the study treatments as measured with the
Longitudinal Interval Follow-up Evaluation (LIFE) Interview
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01153867 -
Schema Focused Therapy for Chronic Depression
|
N/A |