Respiratory Distress Syndrome, Adult Clinical Trial
Official title:
Effect of the Positive Expiratory Pressure on the Right Ventricular Function in Patient With Adult Respiratory Distress Syndrome Ventilated With Limited Plateau Pressure
Verified date | March 2007 |
Source | Assistance Publique - Hôpitaux de Paris |
Contact | n/a |
Is FDA regulated | No |
Health authority | France: Ministry of Health |
Study type | Interventional |
The objective of this study is to analyze by trans-oesophageal echocardiography the effect on the right ventricle of positive expiratory pressure (PEP) level variations with constant plate pressure among patients with syndrome of acute respiratory distress of the adult (SDRA). The assumption tested is that a high level of PEP increases the impedance with the ejection of the right ventricle independently of the level of plate pressure. The effect on the right ventricular preload will be checked via the analysis of the respiratory variability of the diameter of the higher vena cava.
Status | Completed |
Enrollment | 15 |
Est. completion date | September 2006 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. Intubation and artificial ventilation 2. Bilateral pulmonary opacities radiological compatible with an organic pulmonary oedema 3. PaO2/FiO2 report/ratio < 200 mmHg 4. Not obviously clinical or echocardiographic of rise in the pressure of ventricular filling left 5. Joint presence of criteria 2, 3 and 4 since less than 72 hours Exclusion Criteria: 1. Age <18 years 2. Pregnancy 3. Obstructive chronic broncho-pneumonopathy 4. Suspected or confirmed intracranial hypertension 5. Pneumothorax 6. Evolutionary oesophageal pathology 7. Hemodynamic instability with need of filling vascular or modification of posology of the vasopressors in the 2 hours preceding inclusion 8. PaO2/FiO2 Report/ratio < 50 mmHg 9. Amount of adrenaline or noradrenaline higher than 2 mg/hour |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | HOPITAL HENRI MONDOR Department of Neurosurgery | Creteil |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Bouadma L, Lellouche F, Cabello B, Taillé S, Mancebo J, Dojat M, Brochard L. Computer-driven management of prolonged mechanical ventilation and weaning: a pilot study. Intensive Care Med. 2005 Oct;31(10):1446-50. Epub 2005 Aug 23. — View Citation
Lacherade JC, Auburtin M, Cerf C, Van de Louw A, Soufir L, Rebufat Y, Rezaiguia S, Ricard JD, Lellouche F, Brun-Buisson C, Brochard L. Impact of humidification systems on ventilator-associated pneumonia: a randomized multicenter trial. Am J Respir Crit Care Med. 2005 Nov 15;172(10):1276-82. Epub 2005 Aug 26. — View Citation
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