Coronary Arteriosclerosis Clinical Trial
Official title:
Effects of Exercise Training on Left Ventricular Function in Type 2 Diabetic Patients Post Coronary Artery Bypass Graft
The purpose of this study is to investigate the changes of cardiorespiratory fitness and
left ventricular function in type 2 diabetes after uncomplicated coronary artery bypass
graft (CABG) surgery.
We hypothesize that exercise capacity, left ventricular diastolic function, and biochemical
data improves after 12-wk exercise training in patients with type 2 diabetes underwent CABG.
Patients with type 2 diabetes mellitus have higher incidence of coronary artery disease or
left ventricular dysfunction, particularly diastolic dysfunction. Coronary artery bypass
surgery is known to decrease the mortality rate in diabetes. Further exercise training can
improve their cardiorespiratory fitness and the control of risk factors in these patients.
However, the extent of improvement and the mechanism, especially the changes in left
ventricular function, in diabetes after exercise training have not been fully explored.
Subjects will be assigned to the intervention or control group by randomization. Subjects in
the intervention group will receive 60% VO2 max moderate aerobic exercise training, twice
per week under supervision and three times per week at home, for 12 weeks. All subjects
receive left ventricular function test by echocardiography and impedance cardiography,
graded maximal exercise test, and biochemical analyses of sugar and lipid before and after
12 weeks. Their dietary intake and physical activity will be inquired every 4 weeks by
questionnaires.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00069654 -
Dietary Nitrate and Nitrite to Increase Nitric Oxide in Patients With Coronary Artery Disease
|
Phase 2 | |
| Completed |
NCT02919124 -
Epicardial Echocardiography of Coronary Anastomoses Using the Echoclip Device
|
N/A | |
| Recruiting |
NCT02639962 -
Characteristics of Culprit Lesion and Changes in Plaque Composition. A Dual Energy Cardiac CT Study
|
N/A | |
| Completed |
NCT02494557 -
Risk Stratification for Coronary Artery Disease With Type 2 Diabetic Patients
|
N/A | |
| Recruiting |
NCT01466452 -
Antiplatelet Effect of Low Doses of Aspirin Taken Every 12 Hours in Patients Undergoing Coronary Artery Bypass Graft and/or Aortic Valve Surgery
|
Phase 2 | |
| Completed |
NCT01182428 -
XIENCE V: SPIRIT WOMEN Sub-study
|
Phase 4 | |
| Completed |
NCT00368953 -
YUKON Choice Versus TAXUS Liberté in Diabetes Mellitus
|
Phase 4 | |
| Completed |
NCT00371891 -
Ontario Multidetector Computed Tomographic (MDCT) Coronary Angiography Study (OMCAS)
|
Phase 4 | |
| Completed |
NCT00319449 -
Adding Ezetimibe Tablet to Ongoing Treatment With Atorvastatin in Subjects With High Cholesterol and Multiple Coronary Heart Disease Risk Factors (Study P04060)(COMPLETED)
|
Phase 4 | |
| Completed |
NCT00091754 -
Atherosclerosis, Plaque and CVD in Communities
|
||
| Completed |
NCT00069797 -
Epidemiology of Coronary Heart Disease in Men Aged 40 and Over
|
N/A | |
| Completed |
NCT00037245 -
Androgens and Subclinical Atherosclerosis in Young Women - Ancillary to CARDIA
|
N/A | |
| Completed |
NCT00024596 -
Family Heart Study - Subclinical Atherosclerosis Network (FHS-SCAN)
|
N/A | |
| Completed |
NCT00006407 -
Sex Steroid Hormones and Risk of CHD in Women
|
N/A | |
| Withdrawn |
NCT00006497 -
Long-Term Effects of Subclinical CAD on Cardiac Function
|
||
| Completed |
NCT00006502 -
Myocardial Perfusion, Risk Factors, and Coronary Calcium
|
N/A | |
| Completed |
NCT00006309 -
Pooling of Cohort Studies on Diet & Coronary Disease
|
N/A | |
| Completed |
NCT00005269 -
Family Blood Pressure Program - GENOA
|
||
| Completed |
NCT00000508 -
Stanford Coronary Risk Intervention Project (SCRIP)
|
Phase 3 | |
| Completed |
NCT00005147 -
Epidemiology of Atherosclerosis
|
N/A |