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Osteoarthritis, Knee clinical trials

View clinical trials related to Osteoarthritis, Knee.

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NCT ID: NCT06466850 Recruiting - Clinical trials for Osteoarthritis, Knee

Mesenchymal Stem Cells Derived Exosomes in Osteoarthritis Patients

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

Present research focuses on the potential of exosomes, which are small vesicles secreted by mesenchymal stem cells (MSCs), as a therapeutic approach for osteoarthritis (OA). OA is a degenerative joint disorder characterized by the destruction of cartilage and loss of extracellular matrix. It's associated with pro-inflammatory cytokines and increased expression of matrix metalloproteinase (MMP) and "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS). MSCs have been explored as a new treatment for OA over the last decade1. It's suggested that the paracrine secretion of trophic factors, in which exosomes play a crucial role, contributes to the mechanism of MSC-based treatment of OA. Exosomes derived from MSCs may suppress OA development. They carry bioactive molecules of the parental cells, including non-coding RNAs (ncRNAs) and proteins and anti-inflammatory factors. These exosomes have shown a significant impact on the modulation of various physiological behaviors of cells in the joint cavity. This research provides hope for developing more effective and predictable methods of using MSC-derived exosomes for OA treatment.

NCT ID: NCT06463847 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Start date: June 28, 2024
Phase: Phase 1
Study type: Interventional

In recent years, the incidence rate and disability rate of osteoarthritis have continued to grow, and it has become a common chronic disease of elderly patients, second only to the "three highs", and poses a continuous threat to China's medical and health system and public health system. Knee osteoarthritis is the main type of osteoarthritis, ranking 11th in global disability diseases and 38th in disability adjusted life year loss, causing significant economic burden to patients, families, and society. At present, most of the treatment methods for KOA have limited efficacy, only relieving pain symptoms and cannot prevent cartilage damage and other tissue damage in the joints. Due to the limitations of adverse events, there is still no optimal treatment plan for KOA. Most studies believe that autologous mesenchymal stem cell transplantation is a new treatment method with good efficacy and good repair effect for mild to moderate cartilage defects. Given that there is currently no optimal treatment plan for KOA, human umbilical cord mesenchymal stem cell injection has potential development value and is of great significance for the treatment of KOA patients.

NCT ID: NCT06463132 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Phase 1b Clinical Trial to Evaluate PEP and EUFLEXXA for Knee Osteoarthritis (KOA)

Start date: November 1, 2024
Phase: Phase 1
Study type: Interventional

Evaluate the safety and exploratory efficacy of single intra-articular injections of PEP reconstituted with 0.9% Normal Saline at a low dose (one vial PEP) and high dose (two vials PEP), with and without EUFLEXXA, for the treatment of Knee Osteoarthritis

NCT ID: NCT06462625 Active, not recruiting - Knee Osteoarthritis Clinical Trials

Clinical and Radiological Results of Long Term Tibial and Femoral Osteotomy in Knee Ostheoarthritis With Concomitant Lower Limb Malalignement

KNEE OSTEOTOMY
Start date: January 12, 2023
Phase:
Study type: Observational [Patient Registry]

The present study aims to evaluate the long-term and medium-term outcomes of different knee osteotomy techniques in the treatment of knee osteoarthritis in patients with lower limb malalignment. This evaluation is necessary in the current context of research on the treatment and prevention of knee osteoarthritis through treatments that do not involve or allow for the postponement of prosthetic replacement. Among the biological treatments performed in orthopedic clinical practice, osteotomy is one of the most promising. However, further long-term evaluations are needed to more clearly determine the indications and potential of this type of intervention, considering the various surgical procedures described for performing it.

NCT ID: NCT06462560 Recruiting - Knee Osteoarthritis Clinical Trials

Live and Interactive Fitness Training Program (Vivo Knee OA)

LIFT-OA
Start date: April 28, 2024
Phase: N/A
Study type: Interventional

Potential participants will be screened at clinic. Patients who meet eligibility criteria will be considered for study. After written informed consent is obtained, participants will complete baseline testing and participants who meet eligibility criteria will be randomized 1:1 to 2 treatment arms: Vivo Arm: Vivo twice a week for 6 months and Usual Care Arm: meet with ATC and given Medbridge home exercise program for 6 months. All participants will be followed for 12 months, and will be assessed at 3-,6-, and 12-months. All participants will complete functional assessments, OA patient reported outcomes measures, quality of life, exercise self-efficacy, and fall risk questionnaires, and health care utilization report at each testing visit. A subset of Vivo participants will be asked satisfaction questions at the 3 and 6 month time points.

NCT ID: NCT06460662 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Effects of Agility and Perturbation Based Training in Addition to Routine Physical Therapy

Start date: June 2024
Phase: N/A
Study type: Interventional

Osteoarthritis is a degenerative joint disease. Knee OA patients sometimes report episodes of knee instability that limit their ADLs. The episodes of instability are similar to those reported in knee ligament injuries. It is believed that modifications of interventions that are used to promote knee stability in knee ligament injuries can be used in knee OA to enhance knee stability and function. The purpose of this study will be to determine the effects of agility and perturbation-based training in addition to routine physical therapy on pain, function, quality of life and disability in knee osteoarthritis.

NCT ID: NCT06460168 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Mulligan and Maitland Techniques in Post PRP Knee Osteoarthritis

Start date: June 15, 2024
Phase: N/A
Study type: Interventional
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NCT ID: NCT06459960 Completed - Clinical trials for Osteoarthritis, Knee

Effect of Hydrotherapy After Unilateral UKA

Start date: December 15, 2020
Phase: N/A
Study type: Interventional
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NCT ID: NCT06459817 Not yet recruiting - Clinical trials for Osteoarthritis, Knee

Quantitative Assessment of BB-02 Therapy Effect on Cartilage Status in Patients Affected by Early Knee Osteoarthritis

JOCARE-OA
Start date: June 2024
Phase: N/A
Study type: Interventional
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NCT ID: NCT06459700 Not yet recruiting - Knee Osteoarthritis Clinical Trials

Effect of Probiotic Supplements on Osteoarthritis Outcomes

ProOA23
Start date: June 15, 2024
Phase: N/A
Study type: Interventional

Dysbiosis of the gut microbiota is believed to contribute to the development and progression of osteoarthritis (OA), suggesting a role for probiotics in the treatment of OA. Animal studies have shown that certain probiotic strains decrease the inflammatory responses, pain sensitization and OA progression. There are, however, few clinical studies in humans to support this. In this double-blinded randomized controlled trial we will investigate the effect of 6-months probiotic supplements compared to placebo on OA related outcomes in females with diagnosed knee OA.