Osteo Arthritis Knee Clinical Trial
Official title:
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention
The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.
After being informed about the study and potential risks and all participants giving written informed consent, this project will establish a cohort of young men and women who within six weeks have sustained an acute rupture of the ACL. The cohort is randomized into a control and treatment group, where the treatment group receives a zoledronic acid injection at baseline. The cohort will be followed radiographically with high resolution peripheral quantitative computed tomography (HR-pQCT), dual electron computed tomography (DECT), digital radiography (X-Ray), bi-planar X-ray (EOS) and magnetic resonance imaging (MRI) for six months to monitor the progression of joint changes and the effects of zoledronic acid. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04040985 -
Legion Primary Safety and Efficacy
|
N/A | |
Recruiting |
NCT04525950 -
Robotized Navigation Compared to Conventional Technique in Total Knee Replacement
|
N/A | |
Recruiting |
NCT04320914 -
High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis
|
N/A | |
Completed |
NCT03886142 -
Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis
|
N/A | |
Recruiting |
NCT04072055 -
MOTO Post-marketing Surveillance Study
|
||
Not yet recruiting |
NCT05290818 -
Total Versus Robotic Assisted Unicompartmental Knee Replacement
|
N/A | |
Withdrawn |
NCT03271229 -
Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee
|
Phase 2 | |
Suspended |
NCT03847324 -
Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty
|
N/A | |
Recruiting |
NCT05126485 -
Biofeedback Retention in Individuals With AKA
|
Early Phase 1 | |
Completed |
NCT04231318 -
Study of Cingal® and Triamcinolone Hexacetonide for the Relief of Knee Osteoarthritis Pain
|
Phase 3 | |
Recruiting |
NCT04956393 -
The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study
|
N/A | |
Recruiting |
NCT04541342 -
Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy
|
N/A | |
Completed |
NCT04391842 -
Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis
|
Phase 1 | |
Completed |
NCT03680807 -
Power Production in Older Adults With Knee Osteoarthritis
|
||
Completed |
NCT03783455 -
Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis
|
N/A | |
Completed |
NCT05089253 -
Effect of Physical Therapy Modalities in Osteoarthritis
|
N/A | |
Completed |
NCT04536519 -
Foot Wear Modification Along With Physical Therapy in Knee Osteoarthritis
|
N/A | |
Not yet recruiting |
NCT04635176 -
Comparing Local Anesthesia With and Without iPACK Block
|
Phase 4 | |
Recruiting |
NCT04099394 -
Pain & Aging: Combined Interventions for Fitness in the Community Study
|
N/A | |
Recruiting |
NCT03196011 -
Traditional Versus Alternative Alignment in TKR
|
N/A |