Clinical Trials Logo

Clinical Trial Summary

The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.

Clinical Trial Description

After being informed about the study and potential risks and all participants giving written informed consent, this project will establish a cohort of young men and women who within six weeks have sustained an acute rupture of the ACL. The cohort is randomized into a control and treatment group, where the treatment group receives a zoledronic acid injection at baseline. The cohort will be followed radiographically with high resolution peripheral quantitative computed tomography (HR-pQCT), dual-energy computed tomography (DECT), digital radiography (X-Ray), bi-planar X-ray (EOS) and magnetic resonance imaging (MRI) for eighteen months to monitor the progression of joint changes and the effects of zoledronic acid. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05204836
Study type Interventional
Source University of Calgary
Contact Steven Boyd, PhD
Phone 4032203664
Status Recruiting
Phase Phase 1
Start date May 16, 2023
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Terminated NCT04040985 - Legion Primary Safety and Efficacy N/A
Active, not recruiting NCT04525950 - Robotized Navigation Compared to Conventional Technique in Total Knee Replacement N/A
Recruiting NCT04320914 - High Intensity Laser Therapy (Classes IV) and Ibuprofen Gel Phonophoresis for Treating Knee Osteoarthritis N/A
Completed NCT03886142 - Platelet Rich Plasma Versus Radio Frequency for Chronic Knee Arthritis N/A
Terminated NCT04072055 - MOTO Post-marketing Surveillance Study
Not yet recruiting NCT06385275 - The Role of Vitamin K on Knee Osteoarthritis Outcomes Phase 1/Phase 2
Not yet recruiting NCT05290818 - Total Versus Robotic Assisted Unicompartmental Knee Replacement N/A
Withdrawn NCT03271229 - Conventional Platelet-Rich Plasma Versus Concentrated Bone Marrow Stem Cell Injections for Osteoarthritis of the Knee Phase 2
Recruiting NCT05505552 - Effects of Vitamin K on Lower-extremity Function in Adults With Osteoarthritis: N/A
Recruiting NCT05992038 - Use of a Putty as Gap Filler in Open-wedge Osteotomy N/A
Recruiting NCT06066684 - Pain Phenotyping in Knee OA: a Pilot Trial
Completed NCT03847324 - Physiotherapy and Therapeutic Education on Patients With Pain Catastrophism Scheduled for a Total Knee Arthroplasty N/A
Recruiting NCT05126485 - Biofeedback Retention in Individuals With AKA Early Phase 1
Completed NCT04956393 - The SOAR (Stop OsteoARthritis) Program Proof-of-Concept Study N/A
Recruiting NCT04541342 - Arthroscopic Evaluation of Cartilage Regeneration After Opening-wedge High Tibial Osteotomy N/A
Completed NCT04391842 - Sustained Acoustic Medicine (SAM) Combined With a Diclofenac Ultrasound Coupling Patch for Knee Osteoarthritis Phase 1
Completed NCT03680807 - Power Production in Older Adults With Knee Osteoarthritis
Completed NCT03783455 - Effectiveness of Five Intraarticular Strategies on Knee Osteoarthritis N/A
Not yet recruiting NCT06264362 - Developing a Nonpharmacological Pain Intervention for Community-dwelling Older Adults With Dementia N/A
Completed NCT05089253 - Effect of Physical Therapy Modalities in Osteoarthritis N/A