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Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention Following an Acute Knee Injury — ZAPOA  

Osteo Arthritis Knee Clinical Trial

Official title:
Altering Bone Microarchitecture and Mechanics by Off-label Pharmaceutical Intervention

Clinical Trial Summary

The purpose of this study is to assess if a zoledronic acid injection can alter the trajectory of joint degeneration following an acute anterior cruciate ligament (ACL) injury.

Clinical Trial Description

After being informed about the study and potential risks and all participants giving written informed consent, this project will establish a cohort of young men and women who within six weeks have sustained an acute rupture of the ACL. The cohort is randomized into a control and treatment group, where the treatment group receives a zoledronic acid injection at baseline. The cohort will be followed radiographically with high resolution peripheral quantitative computed tomography (HR-pQCT), dual-energy computed tomography (DECT), digital radiography (X-Ray), bi-planar X-ray (EOS) and magnetic resonance imaging (MRI) for eighteen months to monitor the progression of joint changes and the effects of zoledronic acid. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05204836
Study type Interventional
Source University of Calgary
Contact Steven Boyd, PhD
Phone 4032203664
Email skboyd@ucalgary.ca
Status Recruiting
Phase Phase 1
Start date May 16, 2023
Completion date December 31, 2024
View Details
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