Inflammatory Response to Opioid Versus Opioid Free Anesthesia

Status Completed

Clinical Trial Summary

Anesthetic agents, including opioids can modulate the altered immune function in patients with obesity through mechanisms that involve the expression and release of cytokines. For this reason, anesthetic care in patients with obesity remains controversial. Therefore, the aim of the study was to compare the effect of opioid-containing anesthesia vs opioid-free anesthesia using the Cortínez-Sepúlveda model on serum levels of IL-6, IL-1β and TNF-α before and after surgery in obese patients undergoing bypass surgery. Methods: A randomized cross-sectional study of 40 unrelated obese adults was performed in the Anesthesiology and Bariatric Surgery Service at the Civil Hospital of Guadalajara "Dr. Juan I. Menchaca". Before undergoing laparoscopic Roux-en-Y gastric bypass, patients were randomly assigned to two anesthesia groups: opiod-containing (n=20) or opioid-free (n=20). The opioid used in the opioid-containing anesthesia group was fentanyl. To characterize the disposition of intravenous propofol for the target-controlled infusion technique in obese patients, the Cortínez-Sepúlveda pharmacokinetic model was used. Body mass was determined to the nearest 0.05kg using a balance scale (Seca 703; Seca, Hamburg, Germany). Blood samples were taken before and immediately after surgery and cytokine serum levels were determined with ELISA kits. Statistical analyses were performed using the IBM Statistical Package for the Social Sciences software package version 20.0 (IBM Corp., Armonk, NY, USA).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04854252
Study type	Interventional
Source	University of Guadalajara
Contact
Status	Completed
Phase	N/A
Start date	November 12, 2020
Completion date	March 29, 2021

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04095624` - Does Preoperative Pain Medication Management Influence Surgical Outcomes in Spinal Fusion	N/A
Completed	`NCT04484610` - Appropriate Opioid Quantities for Acute Pain - Pharmacist Study	Phase 4
Recruiting	`NCT04598074` - Opioid Package Prototype (OPP)	N/A
Recruiting	`NCT06033599` - Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement	Phase 3
Recruiting	`NCT06032559` - Implementation and Effectiveness of Mindfulness Oriented Recovery Enhancement as an Adjunct to Methadone Treatment	Phase 3
Completed	`NCT05845177` - Persistent Pain After Hip Replacement
Completed	`NCT03570320` - Does Altering Narcotic Prescription Methods Affect Opioid Distribution Following Select Upper Extremity Surgeries?	N/A
Completed	`NCT03268551` - MEMO-Medical Marijuana and Opioids Study
Completed	`NCT04526236` - Influence of Aging on Perioperative Methadone Dosing	Phase 4
Completed	`NCT05593341` - Opioid Education in Total Knee Arthroplasty	N/A
Recruiting	`NCT05877157` - Pain AND Opioids After Surgery
Recruiting	`NCT06055205` - A Pain and Coordination Plan for Reduced Opioid Use After Accidental Injuries	N/A
Recruiting	`NCT03675386` - Reducing Opioid Use for Chronic Pain Patients Following Surgery	N/A
Suspended	`NCT05001789` - Cognitive Functioning in Opioid Use Disorder	N/A
Completed	`NCT04296396` - Opioid Prescription After Cesarean Trial	Phase 3
Not yet recruiting	`NCT04868552` - Naloxone Education in Total Joint Patients	N/A
Completed	`NCT03540030` - Opioid-Free Shoulder Arthroplasty	Phase 4
Terminated	`NCT06217380` - Feasibility and Acceptability of Oxygen Saturation Monitoring Using Masimo SafetyNet Alert (MSNA) in a Supportive Housing Program	N/A
Recruiting	`NCT05976646` - Phase Ib/2a Drug-drug Interaction Study of a Combination of 45mg Dextromethorphan With 105 mg Bupropion	Phase 1/Phase 2
Completed	`NCT03472521` - Prevention of Persistent Opioid Use in Mothers	Phase 4