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Opioid-Related Disorders clinical trials

View clinical trials related to Opioid-Related Disorders.

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NCT ID: NCT03151655 Withdrawn - Opioid Use Disorder Clinical Trials

Changing Opioid Users' Negative Attitudes Toward Medication Assisted Treatment

Start date: January 2019
Phase: N/A
Study type: Interventional

In this treatment development project, the investigators propose to develop and assess the feasibility and acceptability of a narrative-based video intervention and accompanying workbook (entitled MATTeRS: Medication Assisted Treatments: Telling Real Stories) designed to be used by people in inpatient opioid detoxification. Using the Health Belief Model as a framework, videos will provide information about the uses and outcomes of Medication Assisted Treatments (MATs) compared to other or no post-detoxification treatment through the use of narratives from real people's lives.

NCT ID: NCT03137030 Withdrawn - Pain, Postoperative Clinical Trials

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults

Start date: September 2017
Phase: Phase 1
Study type: Interventional

This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of different amounts of tablets of a new and a marketed tablet formulation in healthy adults. Part 1 is a randomized, single-site, open-label, 4-treatment, 4-period crossover, single oral dose Phase I trial in 32 healthy male and female subjects. Part will consist of an Enrollment Visit, 4 treatment periods (each lasting approximately 90 hours), and a Final Examination. The treatment periods will be separated by a washout period each lasting at least 7 days. Part 2 is optional and depending on pharmacokinetic data review after Part 1. It is a randomized, single-site, open-label, 2-treatment, 2-period crossover, single oral dose part in healthy male and female subjects. Part 2 will consist of an Enrollment Visit, 2 treatment periods (each lasting approximately 90 hours) and a Final Examination. The treatment periods will be separated by a washout period lasting at least 7 days. Participants must fast for approximately 10 hours prior to administration of Investigational medicinal product (IMP) and until approximately 4 hours after the administration of the IMP.

NCT ID: NCT03137017 Withdrawn - Pain, Postoperative Clinical Trials

A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults

Start date: September 2017
Phase: Phase 1
Study type: Interventional

This clinical trial is being conducted to compare concentrations of hydrocodone and acetaminophen in the blood after administration of a new and a marketed tablet formulation under fasted and fed conditions in healthy adults. This is a randomized, single-site, open-label, 4-treatment, 4-period crossover, single oral dose Phase I trial in 32 healthy male and female subjects. The trial will consist of an Enrollment Visit, 4 treatment periods (each lasting approximately 60 hours) separated by 3 washout periods (each lasting at least 7 days), and a Final Examination.

NCT ID: NCT01183130 Withdrawn - Opiate Dependence Clinical Trials

Compliance Monitoring in Real Time During Opioid Substitution Treatment

Start date: August 2011
Phase: N/A
Study type: Interventional

The aim of the study is to examine whether electronic compliance monitoring in real time could offer some advantages compared to normal electronic monitoring in opioid substitution treatment. The investigators would also like know whether this method could enable the quick detection of possible problems in medication intakes and/or prevent the abuse or diversion of substitution medications.

NCT ID: NCT01160432 Withdrawn - Opiate Dependence Clinical Trials

Naloxone Methadone Combination (NAMEKO)

NAMEKO
Start date: May 2013
Phase: N/A
Study type: Interventional

The aim of the study is to examine the tolerability and abuse potential of the diluted methadone solution (5 mg/ml → 2 mg/ml) in combination with naloxone in opioid substitution treatment. Study hypothesis: Treatment with this diluted combination product is safer than with methadone alone (5 mg/ml) and combination product does not precipitate withdrawal symptoms in opioid dependent patients.

NCT ID: NCT00398008 Withdrawn - HIV Infections Clinical Trials

HIV Risk Reduction and Drug Abuse Treatment in Iran

Start date: October 2004
Phase: Phase 2
Study type: Interventional

A randomized, double blind clinical trial comparing buprenorphine and naltrexone maintenance treatment when combined with drug abuse and HIV risk reduction counseling (DC-HIV) for heroin and opium addicts in Iran.

NCT ID: NCT00000331 Withdrawn - Clinical trials for Opioid-Related Disorders

Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-3 - 6

Start date: December 2002
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in healthy, non-drug dependent volunteers.

NCT ID: NCT00000330 Withdrawn - Clinical trials for Opioid-Related Disorders

Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-2 - 5

Start date: October 1999
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the abuse liability and reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in heroin-dependent volunteers

NCT ID: NCT00000329 Withdrawn - Clinical trials for Opioid-Related Disorders

Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment II-1 - 4

Start date: April 1999
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the abuse liability and examine the reinforcing effects of intravenous buprenorphine and buprenorphine/naloxone combinations in buprenorphine-naloxone maintained volunteers

NCT ID: NCT00000328 Withdrawn - Clinical trials for Opioid-Related Disorders

Buprenorphine/Naloxone Treatment for Opioid Dependence-Experiment III) - 3

Start date: July 1997
Phase: Phase 2
Study type: Interventional

The purpose of this study is to compare the clinical efficacy of the buprenorphine/naloxone combination tablet to methadone for opioid maintenance treatment.