Obstructive Sleep Apnea Clinical Trial
Official title:
Masked Hypertension Evaluated by Automated Office Blood Pressure Measurement (AOBPM) and Office Blood Pressure Measurement (OBPM) in Patients With Obstructive Sleep Apnoea
Assessment of the possible difference in masked hypertension prevalence when it is evaluated by automated office blood pressure measurement (AOBPM) instead of office blood pressure measurement (OBPM) in patients with obstructive sleep apnoea.
Rationale:
Obstructive sleep apnoea is characterized by repetitive closure of upper airways leading to
apnoea (complete airflow cessation) or hypopnoea (airflow limitation > 50%+ blood oxygen
desaturation > 4%). It is considered to be an important risk factor for arterial
hypertension. In these patients is highly prevalent nocturnal hypertension (NH) and also
masked hypertension (MH). Ambulatory blood pressure monitoring (ABPM) is considered to be a
gold standard for the diagnosis of NH and MH. Results of ABPM are compared with office blood
pressure measurement which could be falsely elevated in some patients (white coat effect).
For this reason, automatic office blood pressure measurement was developed. Nowadays some
devices like BpTRU were developed. This was validated on some patient groups but robust data
for patients with obstructive sleep apnoea are missing.
Process:
Patient with ronchopathy and suspected obstructive sleep apnoea undergo automated office
blood pressure monitoring followed by office blood pressure monitoring at the Department of
Exercise Medicine and Cardiovascular Rehabilitation. After education, ambulatory blood
pressure monitor will be provided to patients for the following 24 hours. In the same night,
respiratory polygraphy will be performed in the Sleep Laboratory, Department of Respiratory
Medicine, University Hospital Olomouc. All data will be statistically evaluated after
completion of the target number of subjects. Patients without obstructive sleep apnoea
(apnoea-hypopnoea index < 5) will not be included in statistical evaluations.
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