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Obstructive Sleep Apnea clinical trials

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NCT ID: NCT01678560 Terminated - Clinical trials for Obstructive Sleep Apnea

Remote Monitoring in Obstructive Sleep Apnea

Start date: January 2014
Phase: N/A
Study type: Interventional

Obstructive sleep apnea (OSA) among Veterans is a condition that imparts a great burden to the patient in terms of serious co-morbidities and results in a great cost to the VA Health Care System to treat the co-morbidities, which include heart disease, stroke and neuropsychiatric disorders. Positive airway pressure (PAP) is used to treat sleep apnea and studies have shown a poor adherence to treatment. The investigators hypothesize that using wireless technology will lead to early detection of problems of treatment use and will translate into early remedial action which will improve the use and effectiveness of treatment. The investigators will compare two methods. Usual care involves downloading data from PAP machines at designated 3-month intervals, requiring a face-to-face clinician visit. Wireless care involved more frequent monitoring and intervention in the event of anomalies in treatment use or effectiveness.

NCT ID: NCT01554488 Terminated - Asthma Clinical Trials

Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease

InFLOW
Start date: March 12, 2013
Phase: Phase 4
Study type: Interventional

The Chairman of the Veterans' Disability Benefits Commission reported at a recent US Senate hearing that asthma, chronic obstructive pulmonary disease (COPD), and sleep apnea are among the top 13 most frequent diagnoses leading to disability under the Department of Defense and the VA system statutes. Recent research finds that sleep apnea is more common among asthma and COPD individuals, and this may be caused by inhaled corticosteroid use. Many Veterans are currently using inhaled corticosteroids, and many more will be prescribed such medications, given their recent inclusion in international treatment guidelines. As such, this study addresses a critical need by researching the role of a potent inhaled corticosteroid in promoting sleep apnea, the determinants of this response, and the ways through which it occurs. Results from this study will form the foundation for future research aimed at expanding understanding of the effects of inhaled corticosteroids on the upper airway, as well as developing means to prevent or counteract them.

NCT ID: NCT01446601 Terminated - Clinical trials for Obstructive Sleep Apnea

Apnex Clinical Study of the Hypoglossal Nerve Stimulation (HGNS®) System to Treat Obstructive Sleep Apnea

Start date: August 2011
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate the benefits and risks of hypoglossal nerve stimulation with the Apnex Medical Hypoglossal Nerve Stimulation (HGNS) System as a potential therapeutic option for individuals with moderate to severe Obstructive Sleep Apnea (OSA) that have failed or do not tolerate positive airway pressure (PAP) therapy.

NCT ID: NCT01349205 Terminated - Clinical trials for Obstructive Sleep Apnea

Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study

Start date: March 2010
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate whether a smaller dose of caffeine sodium benzoate 10 mg/kg IV is as effective as 20 mg/kg IV in decreasing the number of children who develop post extubation adverse upper airway respiratory events compared to placebo.

NCT ID: NCT01217346 Terminated - Clinical trials for Obstructive Sleep Apnea

A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram

Start date: February 2009
Phase: N/A
Study type: Observational

Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.

NCT ID: NCT01136122 Terminated - Clinical trials for Obstructive Sleep Apnea

Effects of PAP Treatment of OSA in Patients With Heart Failure

OSA-MRI
Start date: April 2010
Phase: N/A
Study type: Interventional

The purpose of this study is to see if treatment of OSA with the CPAP device makes a difference to insulin resistance and heart disease.

NCT ID: NCT01051297 Terminated - Clinical trials for Obstructive Sleep Apnea

Obstructive Sleep Apnea and Venous Thromboembolism

OSAVTE
Start date: March 2009
Phase: N/A
Study type: Observational

There is a clear link between obstructive sleep apnea (OSA) and cardiovascular disease. However, there has been no clear link between OSA and venous thromboembolism (VTE). The objective of this study is to evaluate such a link.

NCT ID: NCT01027806 Terminated - Clinical trials for Obstructive Sleep Apnea

Effect of Montelukast Therapy in Obstructive Sleep Apnea(OSA) Children

32543
Start date: July 2010
Phase: Phase 4
Study type: Interventional

The investigators leading hypotheses are: - Oral therapy with montelukast may lead to improved sleep study findings in children with mild to moderate Obstructive Sleep Apnea Syndrome (OSAS) who require surgical removal of adenoids and tonsils for OSAS. - A significant proportion of the children with OSAS treated with montelukast will show reduced severity of OSAS, and this will remove the need for surgical intervention.

NCT ID: NCT01027078 Terminated - Clinical trials for Obstructive Sleep Apnea

Mechanism of Endothelial Dysfunction in Obstructive Sleep Apnea (OSA)

Start date: November 2009
Phase:
Study type: Observational

The investigators hypothesized that patients with Obstructive Sleep Apnea (OSA) who are free of any cardiovascular disease will have early microcirculatory changes that are unique to OSA, and therefore would resolve with treatment of OSA.

NCT ID: NCT00952211 Terminated - Stroke Clinical Trials

Burden of Obstructive Sleep Apnea in Stroke (BOSAST)

BOSAST
Start date: August 2009
Phase: Phase 4
Study type: Interventional

There are two purposes of this study. The first purpose is to define the frequency of obstructive sleep apnea in stroke survivors as well as its association with fatigue and quality of life. The second purpose is to determine if continuous positive airways pressure (CPAP) treatment can have a beneficial effect on these patients' fatigue and quality of life.