View clinical trials related to Obstructive Sleep Apnea (OSA).
Filter by:The purpose of this study is to compare a modified AutoSet algorithm running on research hardware versus the traditional AutoSet algorithm running on an S7 AutoSet Spirit. The study will determine if the modified AutoSet algorithm reacts appropriately to obstructive apnoeas and hypopnoeas and provides suitable levels of positive airway pressure compared to the S7 AutoSet Spirit. The hypothesis is that the modified AutoSet algorithm will be more efficacious than the traditional AutoSet algorithm
The purpose of the study is to: - recruit subjects with untreated sleep apnea; assess overnight changes in their blood and urine chemicals - review the overnight changes in blood and urine chemicals after they have been treated for sleep apnea - assess the overnight changes in blood and urine chemicals in healthy individuals with no sleep problems - compare the amount of fat in the belly using a Magnetic Resonance Imaging (MRI) scanner on all subjects
Obstructive sleep apnoea (OSA) is characterised by a partial or complete collapse of the upper airway during sleep. The treatment of choice for OSA is Continuous Positive Airway Pressure (CPAP). CPAP acts as a positive airway splint, delivering a fixed positive airway pressure to the upper airway via a tube and mask. Compliance, however, to therapy requires that the mask is suitably comfortable so as not to disturb sleep. A key contributor to comfort is the seal component of the mask system. Current mask seals are mainly silicone elastomers, which though well understood and accepted, are often uncomfortable. It is proposed to replace the solid elastomer with a soft polymer foam. The foam is highly porous, and has open cells at its surface. It is therefore more likely to accumulate biological material with repeated use. The current (silicone) material does not present any problematic bioburden issues. Therefore it is important to investigate whether the foam will present bioburden problems to patients, within specified usage parameters. The aims of this study therefore are: 1. to observe the rate of bacterial accumulation on foam mask seal material (polyether polyurethane,) 2. to determine the replacement interval for a foam mask seal, and 3. assess the comfort and function of a foam mask seal.
This study is designed to determine the effectiveness of two different CPAP devices. One a standard CPAP which has the ability to store comprehensive compliance and efficacy data and the second a auto adjusting CPAP which uses the energy spectrum analysis of flow signals to automatically adjust CPAP pressure and improve sleep variables.
The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in men and women.