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Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes (DIABeat) — DiabEATit  

Obesity Clinical Trial

Official title:
Deciphering the Role of Incretin Hormones in Weight Loss-induced Remission of Type 2 Diabetes

Clinical Trial Summary

The goal of this mechanistic study is to investigate the role of incretin hormones on weight loss-induced type 2 diabetes remission.

Clinical Trial Description

Participants will undergo an intensive, individualized dietary treatment to achieve a 10% reduction in body weight, during which glucose-lowering therapy will be withdrawn. Before and after the intervention, the patients will undergo: - measurement of fasting glucose and glycated hemoglobin - Indirect calorimetry - oral glucose tolerance test - intravenous glucose tolerance test - quality of life and diet-related questionnaires - 72-hour food records At the end of the protocol, subjects will be followed up to maintain lifestyle changes and intercept cases of diabetes relapse. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06333132
Study type Interventional
Source Azienda Ospedaliero, Universitaria Pisana
Contact Domenico Tricò, MD, PhD
Phone 050993640
Email d.trico@unipi.it
Status Not yet recruiting
Phase N/A
Start date September 1, 2024
Completion date February 1, 2026
View Details
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