The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation

Obesity Clinical Trial

Official title: The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation

Status Completed

Clinical Trial Summary

A key area of obesity research has focused on the link between appetite, energy balance and weight control. Within this area, several appetite-related hormones and cellular cytokines have been identified as key signals influencing appetite and food intake. This includes the appetite-suppressing hormone oxyntomodulin (OXM) and a cellular stress-induced cytokine growth differentiation factor 15 (GDF-15).

The aims of this study are: (1) to investigate the effect of acute moderate-intensity continuous exercise on oxyntomodulin and GDF-15 concentrations; (2) to investigate whether exercise-induced changes in circulating OXM and GDF-15 concentrations are correlated with subjective appetite perceptions and subsequent energy intake.

Clinical Trial Description

Oxyntomodulin is thought to promote weight loss by suppressing appetite and energy intake and increasing energy expenditure. Acute exercise has been shown to increase the circulating concentration of satiety-related gut hormones, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). However, the effect of acute exercise on OXM concentrations in individuals with healthy weight has not been investigated.

GDF-15 is a cellular stress-induced cytokine which has recently been shown to suppress appetite. A few studies have explored the effect of acute exercise on GDF-15 concentrations but the findings are conflicting. Some studies have shown that acute exercise, which provides a transient physiological stress, increased GDF-15 concentrations, but other studies have not found any influence of exercise on GDF-15 concentrations. In addition, whether post-exercise appetite perceptions and subsequent energy intake are influenced by exercise-related changes in OXM or GDF-15 concentrations remains unknown.

To explore the impact of acute moderate-intensity continuous exercise on OXM and GDF-15 levels, alongside subjective appetite perceptions and subsequent energy intake, all participants in this crossover study engaged in both exercise and control trials, with a minimum one-week interval between each.

During the exercise trial, participants were asked to arrive at the lab at 8.30 am, having fasted overnight for 10 hours (except plain water). Participants were asked to rest in the lab for 30 minutes. During the resting period, a cannula was positioned in the participants' arm and a mask was fitted on the face in the last five minutes of the rest to allow for the collection of exhaled air during exercise. After the resting period, participants were asked to exercise at an intensity of 70 percent of their peak oxygen uptake for an hour before resting in the lab for a further 2.5 hours. Venous blood samples were collected before (0 minutes) and after (60, 90, 120, 150, 180, and 210 minutes) exercise and ad libitum energy intake was assessed 1 h after exercise completion. For the control trial, participants replicated all the procedures of the exercise trial except they rested for 1 h as the exercise counterpart. ;

Related Conditions & MeSH terms

• Obesity
• Overweight

• NCT number: NCT06296511
• Study type: Interventional
• Source: Loughborough University
• Status: Completed
• Phase: N/A
• Start date: June 23, 2023
• Completion date: November 7, 2023