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NCT05156580 Clinical Trial

Tongzhou Cohort Study

Obesity Clinical Trial

Official title:
Cardiovascular Risk in Elderly Obese Patients With Hypertension During Rapid Urbanization of Tongzhou District: A Cohort Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT05156580
Other study ID # 2021-P2-163-01
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date July 1, 2016
Est. completion date September 1, 2026

Study information
Verified date August 2023
Source Beijing Friendship Hospital
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The present study aimed to investigate the impact of obesity on long-term cardiovascular risk in elderly patients with hypertension.

Description:

Overweight status and obesity are important risk factors leading to hypertension, poor blood pressure control, and poor prognosis. However, the studies focused on elderly patients with hypertension are limited. Therefore, the aim of the present study was to evaluate the long-term impact of obesity on cardiovascular risk in elderly patients with hypertension.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 10750
Est. completion date September 1, 2026
Est. primary completion date July 1, 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 60 Years and older
Eligibility Inclusion Criteria: - Ages of = 60 years - History of hypertension and treatment with anti-hypertension drugs for more than 4 weeks - Availability for follow-up until 2026 - No major barriers to provide written consent Exclusion Criteria: - NA

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• No intervention
This is an observational study without any intervention

Locations
Country Name City State
China Beijing Friendship Hospital, Capital Medical University Beijing Beijing

Sponsors (2)
Lead Sponsor Collaborator
Beijing Friendship Hospital Beijing Tongzhou Yongshun Community Health Service

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Percentage of participants with major adverse cardiovascular events (MACEs) Percentage of participants with major adverse cardiovascular events (MACEs), including all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke and coronary revascularization. 2021-2026
Secondary Percentage of participants with all-cause death Percentage of participants with cardiovascular, non-cardiovascular and undetermined death. 2021-2026
Secondary Percentage of participants with MI Percentage of participants with fatal and nonfatal MI. 2021-2026
Secondary Percentage of participants with stroke Percentage of participants with fatal and nonfatal stroke. 2021-2026
Secondary Percentage of participants undergoing coronary revascularization Percentage of participants undergoing ischemia- and non-ischemia-driven coronary revascularization. 2021-2026
Secondary Change in BP control rate Change in BP control rate (office BP: SBP < 140 mmHg and DBP < 90 mmHg) from baseline to follow-up. 2021-2026
Secondary Change in SBP Change in SBP from baseline to follow-up. 2021-2026
Secondary Change in estimated glomerular filtration rate (eGFR) Change in estimated glomerular filtration rate (eGFR) in ml/min/1.73m2 from baseline to follow-up. 2021-2026
Secondary Change in low-density lipoprotein-cholesterol (LDL-c) Change in low-density lipoprotein-cholesterol (LDL-c) in mmol/L from baseline to follow-up. 2021-2026
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