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Mitigating the Pro-inflammatory Phenotype of Obesity — MAPLE  

Obesity Clinical Trial

Official title:
Mitigating the Pro-inflammatory Phenotype of Obesity

Clinical Trial Summary

The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6). Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral clonidine) compared with a BP-lowering control condition (diuretic, hydrochlorothiazide) or a placebo.

Clinical Trial Description

1. Using a randomized, double-blinded, parallel-design approach, we hypothesize that 4 weeks of SNA blockade (oral clonidine) will cause a significant reduction in expression of inflammatory markers in blood, endothelial cells, and central adipose compared with a BP-lowering control condition using hydrochlorothiazide (HCTZ) and a separate placebo treatment. 2. Determine the extent to which inflammation in the body is caused by elevated sympathetic nerve activity ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04934228
Study type Interventional
Source University of Kansas Medical Center
Contact Seth W Holwerda, Ph,D
Phone 9729223230
Email sholwerda@kumc.edu
Status Recruiting
Phase Phase 1
Start date July 1, 2021
Completion date July 31, 2025
View Details
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