The Effect of Degree of Rice-polishing on Glycaemic Response

Obesity Clinical Trial

Official title:

The Effect of Degree of Rice-polishing on Glycaemic Response

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04228341
• Other study ID #: 2018/01079
• Status: Completed
• Phase: N/A
• Start date: February 13, 2019
• Est. completion date: June 18, 2020

Study information

• Verified date: August 2021
• Source: Clinical Nutrition Research Centre, Singapore
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To investigate the effects of rice polishing on glycaemic and insulinaemic response in healthy Chinese male volunteers.

Description:

There will be a total of 8 test session. Each session will last for 3.5 hours. At each test session, volunteers will be served with test meal and blood will be collected. After an overnight fast, subjects will visit the research center. Two fasting capillary blood samples will be collected via fingerprick. Following the fasting samples, subject will consume the test meals. Further blood samples will be collected at 15, 30, 45, 60, 90, 120, 150, 180 minutes after the ingestion of test meal. These samples will be used to analyses for whole capillary blood glucose. At every 30 minute interval, samples will be collected for analysis of capillary plasma insulin.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: June 18, 2020
• Est. primary completion date: July 26, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 21 Years to 60 Years

Eligibility

Inclusion Criteria:

• Male

• Chinese ethnicity

• Age =21 and = 60 years

• Body mass index between 18.5 to 25 kg/m2

• Normal blood pressure =<140/90 mmHg

• Fasting blood glucose <6.0 mmol/L

• In general good health

Exclusion Criteria:

• Current smoker

• Have any metabolic diseases (such as diabetes, hypertension etc)

• Do not have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)

• Have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)

• Have intolerances or allergies to any foods

• Currently partake in sports at the competitive and/or endurance levels

• Intentionally restrict food intake

Related Conditions & MeSH terms

• Diabetes Mellitus
• Obesity

Intervention

Other:
• Glucose Reference 1
50 g of glucose dissolved in 250 ml of water (First glucose control visit)
• Glucose Reference 2
50 g of glucose dissolved in 250 ml of water (Second glucose control visit)
• Glucose Reference 3
50 g of glucose dissolved in 250 ml of water (Third glucose control visit)
• Brown Rice
Unpolished brown rice containing 50 g of available carbohydrate was cooked using a rice cooker (Toyomi) at a ratio of rice to water of 1: 2
• 3 % polished rice
3% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
• 6 % polished rice
6% polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
• 9 % polished rice
9 % polished rice, containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2
• 20 % Polished rice
White rice (20% polished rice), containing 50 g of available carbohydrate was cooked using a rice cooker at a ratio of rice to water of 1: 2.

Locations

Country	Name	City	State
Singapore	Clinical Nutrition Research Centre	Singapore

Sponsors (1)

Lead Sponsor	Collaborator
Clinical Nutrition Research Centre, Singapore

Country where clinical trial is conducted

Singapore, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Glucose	Whole capillary blood glucose will be measure using Hemocue analyser	Up to 180 minutes
Secondary	Insulin	Capillary plasma will be measure using Cobas analyser	Up to 180 minutes