Obesity Clinical Trial
Official title:
Effects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee Osteoarthritis in Pain Relief, Body Composition, Lower Limb Function and Quality of Life
The purpose of this study was to investigate the effects of obesity on knee degenerative arthritis on body composition after dietary control and elastic resistance exercise; and whether persistent exercise habits and dietary control can relieve pain and strengthen muscle strength. Improve the quality of life and the decline of other risk factors.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | December 31, 2023 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 55 Years and older |
Eligibility | Inclusion Criteria: - Cases of knee joint degeneration diagnosed by orthopedics, rheumatology and immunology physicians. - X-ray interpretation (kellgren & Lawrence grade) grades 1 to 3 or mild to moderate patients. - Willing to sign written consent form. - Pain Index (VAS) ? 4/10. - Men and women over the age of 55. - Body mass index (BMI) ? 27 kg/m^2. Exclusion Criteria: - Unable to act on your own. - X-ray interpretation (kellgren & Lawrence level) is greater than level 3 or is a serious level. - Patients who have undergone knee arthroplasty on one or both feet. - Patients with terminal liver and kidney disease. - Those who are unable to perform physical function measurement after severe diagnosis of heart and lung disease after diagnosis by the physician. - High blood pressure with poor control (systolic blood pressure greater than or equal to 180 mmHg at the time of return). - Pregnant women or breastfeeding women. - Those who have coronary stents, cardiac rhythms, or other metallic substances in the body are not recommended for total body composition analysis. - Those with severe hip, knee, and lower back pain who are unable to perform exercise, other neuromuscular, skeletal joints, or rheumatic diseases may be exacerbated by exercise. Or those who have musculoskeletal injuries in the past six months (such as bruises, fractures, etc.). - Unable to cooperate with the test or halfway through the test. |
Country | Name | City | State |
---|---|---|---|
Taiwan | Chang Gung Medical Foundation | Taipei, Taiwan | Republic OF China |
Lead Sponsor | Collaborator |
---|---|
Chang Gung Memorial Hospital |
Taiwan,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | WOMAC | WOMAC is used to measure the patient's home knee function. Each question is scored using a five-point scale. The higher the score, the worse the knee function.
This study assessed the amount of change in WOMAC scores, whether it was lower than baseline after 12 weeks. |
Baseline and after 3 months | |
Primary | KOOS | KOOS is based on WOMAC and covers a wider range. The score of each topic is 0-4 points. The higher the score after the conversion formula, the better the knee joint function. This study assessed changes in KOOS scores, whether it was higher than baseline after 12 weeks. | Baseline and after 3 months | |
Primary | Body fat percentage | Assess the amount of body fat (%) change, whether it can be less than baseline after 12 weeks | Baseline and after 3 months | |
Primary | Body Mass Index | Assess the amount of Body Mass Index(kg/m^2) change, whether it can be less than baseline after 12 weeks | Baseline and after 3 months | |
Primary | waistline | Waist circumference change from baseline to 12 weeks (cm) | Baseline and after 3 months | |
Secondary | hand grip force measurement | Easy to stand. Used to grasp the grip | Baseline and 3 months | |
Secondary | 2.44m time up to go | Stand up when you hear the start password. Use the brisk walk to bypass the marker point and then return to the chair to sit down. | Baseline and 3 months | |
Secondary | 30 chair stand test | Sit down and stand up to stand upright, then quickly return to sit down for an action, within 30 seconds | Baseline and 3 months | |
Secondary | total cholesterol | Cases will be tested for total cholesterol (mg/dL) in routine outpatient care. This study, at baseline and 12 weeks later, copied the most recent total cholesterol report from the case.
The amount of change in total cholesterol after baseline and 12 weeks was compared. |
Baseline and 3 months | |
Secondary | Low-density cholesterol | Cases in the outpatient routine care will be blood tests for low-density cholesterol (LDL-C, mg / dL), the study of the most recent low-density cholesterol report from the case at baseline and 12 weeks later, compared with baseline and 12 weeks later Low-density cholesterol has changed. | Baseline and 3 months | |
Secondary | triglyceride | Cases will be tested for triglycerides (mg/dL) in routine outpatient care. In the study, at the baseline and after 12 weeks, the most recent triglyceride report from the case was copied.
The amount of change in triglyceride at baseline and after 12 weeks was compared. |
Baseline and 3 months |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04101669 -
EndoBarrier System Pivotal Trial(Rev E v2)
|
N/A | |
Recruiting |
NCT04243317 -
Feasibility of a Sleep Improvement Intervention for Weight Loss and Its Maintenance in Sleep Impaired Obese Adults
|
N/A | |
Terminated |
NCT03772886 -
Reducing Cesarean Delivery Rate in Obese Patients Using the Peanut Ball
|
N/A | |
Completed |
NCT03640442 -
Modified Ramped Position for Intubation of Obese Females.
|
N/A | |
Completed |
NCT04506996 -
Monday-Focused Tailored Rapid Interactive Mobile Messaging for Weight Management 2
|
N/A | |
Recruiting |
NCT06019832 -
Analysis of Stem and Non-Stem Tibial Component
|
N/A | |
Active, not recruiting |
NCT05891834 -
Study of INV-202 in Patients With Obesity and Metabolic Syndrome
|
Phase 2 | |
Active, not recruiting |
NCT05275959 -
Beijing (Peking)---Myopia and Obesity Comorbidity Intervention (BMOCI)
|
N/A | |
Recruiting |
NCT04575194 -
Study of the Cardiometabolic Effects of Obesity Pharmacotherapy
|
Phase 4 | |
Completed |
NCT04513769 -
Nutritious Eating With Soul at Rare Variety Cafe
|
N/A | |
Withdrawn |
NCT03042897 -
Exercise and Diet Intervention in Promoting Weight Loss in Obese Patients With Stage I Endometrial Cancer
|
N/A | |
Completed |
NCT03644524 -
Heat Therapy and Cardiometabolic Health in Obese Women
|
N/A | |
Recruiting |
NCT05917873 -
Metabolic Effects of Four-week Lactate-ketone Ester Supplementation
|
N/A | |
Active, not recruiting |
NCT04353258 -
Research Intervention to Support Healthy Eating and Exercise
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Recruiting |
NCT03227575 -
Effects of Brisk Walking and Regular Intensity Exercise Interventions on Glycemic Control
|
N/A | |
Completed |
NCT01870947 -
Assisted Exercise in Obese Endometrial Cancer Patients
|
N/A | |
Recruiting |
NCT06007404 -
Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
|
||
Recruiting |
NCT05972564 -
The Effect of SGLT2 Inhibition on Adipose Inflammation and Endothelial Function
|
Phase 1/Phase 2 | |
Recruiting |
NCT05371496 -
Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction
|
Phase 2 |