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Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity

Obesity Clinical Trial

Official title:
Metabolic Effects of Very Low Carbohydrate Ketogenic Diet in Subjects With Severe Obesity

Clinical Trial Summary

The very low carbohydrates diet (VLCKD) induces liver steatosis amelioration. Lysosomal acid lipase (LAL) deficiency plays a role in fats accumulation in liver. To date, no studies have assessed LAL activity in morbid obesity. The aim of our study is to evaluate VLCKD impact on metabolic/vascular parameters and LAL activity in obese patients.

A VLCKD is administered for 25 days to 52 morbid obese patients (BMI 44.7±8.3 kg/m², age 49±12.5 years); at baseline and after diet we evaluated: BMI, glyco-lipidic pattern, abdominal ultrasonography (liver steatosis and visceral fat area) and flow-mediated dilation (FMD). In a subgroup of 20 patients we also tested lysosomal acid lipase (LAL)-activity. A group of healthy normal weight subjects (age 43±13, BMI 22.8±2.6 kg/m²) was also included in the study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03564002
Study type Observational
Source University Of Perugia
Contact Graziana Lupattelli, Professor
Phone +390755784023
Email graziana.lupattelli@unipg.it
Status Recruiting
Phase
Start date October 1, 2016
Completion date December 31, 2022
View Details
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